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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders pp 65–94Cite as

Neuroimmune Modulation of Synaptic Function

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Abstract

It is becoming increasingly clear that molecules classically associated with the peripheral immune system participate in the modulation of synaptic function. These molecules are from both the innate and adaptive immune systems, including cytokines, class I major histocompatibility complex (MHCI), and complement cascade components, and are used constitutively by the nervous system as signaling molecules that regulate developmental synapse formation and several forms of synaptic plasticity. In addition, the upregulation of immune molecules associated with neuroinflammatory pathological states such as stroke, trauma, and neurodegenerative disease is likely to disrupt normal signaling events and result in maladaptive modulation of neurotransmission. This chapter will present and discuss current evidence implicating neuroimmune molecules in the constitutive regulation of central nervous system (CNS) synapse function, under both normal and pathological conditions.

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  1. Centre for Research in Neuroscience, McGill University, Montreal General Hospital, L7 217 1650 Cedar Av, Montreal, QC, H3G 1A4, Canada

    Horia Pribiag & David Stellwagen

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  1. Horia Pribiag
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  2. David Stellwagen
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  1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Changhai Cui

  2. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Lindsey Grandison

  3. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Fishers Lane 5635, Bethesda, 20892, Maryland, USA

    Antonio Noronha

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Pribiag, H., Stellwagen, D. (2013). Neuroimmune Modulation of Synaptic Function. In: Cui, C., Grandison, L., Noronha, A. (eds) Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4729-0_3

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