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Cat Scratch Disease and Other Bartonella Infections

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Book cover Hot Topics in Infection and Immunity in Children IX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 764))

Abstract

First described in 1931, cat scratch disease remains the most commonly identified clinical syndrome associated with Bartonella infection. Over the last 20 years, however, the discovery and use of modern diagnostic tests has greatly expanded our understanding of the pathogenesis, clinical spectrum, and treatment options for Bartonella infections of all types. Indeed, each varies substantially depending on the infecting species and the immune status of the host.

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References

  1. Garcia-Caceres U, Barcia FU (1991) Bartonellosis: an immunodepressive disease and the life of Daniel Alcides Carrion. Am J Clin Pathol 95(Supp 1):558–566

    Google Scholar 

  2. Carithers H (1970) Cat-scratch disease. Notes on its history. Am J Dis Child 119:200–203

    Article  CAS  Google Scholar 

  3. Wear DJ, Margileth AM, Hadfield TL et al (1983) Cat-scratch disease: a bacterial infection. Science 225:1403–1405

    Article  Google Scholar 

  4. Stoler MH, Bonfiglio TA, Steigbigel RT et al (1983) An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am J Clin Pathol 80:714–718

    Article  CAS  Google Scholar 

  5. LeBoit PE, Berger TG, Egbert BM et al (1988) Epithelioid haemangioma-like vascular proliferation in AIDS: manifestation of cat-scratch disease bacillus infection? Lancet 1:960–963

    Article  CAS  Google Scholar 

  6. Relman DA, Loutit JS, Schmidt TM et al (1990) The agent of bacillary angiomatosis: an approach to the identification of uncultured pathogens. N Engl J Med 323:1573–1580

    Article  CAS  Google Scholar 

  7. Perkocha, LA, Geaghan SM, Yen TSB et al (1990) Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection. N Engl J Med 323:1581–1586

    Article  CAS  Google Scholar 

  8. Slater, LN, Welch DF, Hensel DH et al (1990) A newly recognized fastidious gram-negative pathogen as a cause of fever and bacteremia. N Engl J Med 32:1587–1593

    Article  Google Scholar 

  9. Relman DA, Falkow S, Le Boit PE et al (1991) The organism causing bacillary angiomatosis, peliosis hepatis, and fever and bacteremia in immunocompromised patients. N Engl J Med 324:1514

    CAS  PubMed  Google Scholar 

  10. Welch DF, Pickett DA, Slater LN et al (1992) Rochalimaea henselae sp. nov., a cause of septicemia, bacillary angiomatosis, and parenchymal bacillary peliosis. J Clin Microbiol 30:275–280

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Lucey D, Dolan M, Moss CW et al (1992) Relapsing illness due to Rochalimaea henselae in immunocompetent hosts: implication for therapy and new epidemiological associations. Clin Infect Dis 14:683–688

    Article  CAS  Google Scholar 

  12. Regnery RL, Anderson BE, Clarridge JE et al (1992) Characterization of a novel Rochalimaea species, R. henselae sp. nov., isolated from blood of a febrile, human immunodeficiency virus-positive patient. J Clin Microbiol 30:265–274

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Regnery RL, Olson JG, Perkins BA et al (1992) Serological response to “Rochalimaea henselae” antigen in suspected cat-scratch disease. Lancet 339:1443–1445

    Article  CAS  Google Scholar 

  14. Zangwill KM, Hamilton DH, Perkins BA et al (1993) Cat-scratch disease in Connecticut: epidemiology, risk factors and evaluation of a new diagnostic test. N Engl J Med 329:8–13

    Article  CAS  Google Scholar 

  15. Anderson B, Kelly C, Threlkel R et al (1993) Detection of Rochalimaea henselae in cat scratch disease skin test antigens. J Infect Dis 168:1034–1036

    Article  CAS  Google Scholar 

  16. Margileth AM, Wear DJ, Hadfield TL et al (1984) Cat-scratch disease: bacteria at the primary inoculation site. JAMA 252:928–931

    Article  CAS  Google Scholar 

  17. Anderson B, Sims K, Regnery R et al (1994) Detection of Rochalimaea henselae DNA in specimens from cat-scratch disease patients by PCR. J Clin Microbiol 32:942–948

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Demers DM, Bass JW, Vincent JM et al (1995) Cat-scratch disease in Hawaii: etiology and seroepidemiology. J Pediatr 127:23–36

    Article  CAS  Google Scholar 

  19. Waldvogel K, Regnery R, Anderson B et al (1994) Disseminated cat-scratch disease: detection of Rochalimaea henselae in affected tissue. Eur J Pediatr 153:23–27

    CAS  PubMed  Google Scholar 

  20. Le HH, Palay DA, Anderson B, Steinberg JP (1994) Conjunctival swab to diagnose ocular cat-scratch disease. Am J Ophthalmol 118:249–250

    Article  CAS  Google Scholar 

  21. Carithers HA, Margileth AM (1991) Cat-scratch disease: acute encephalopathy and other neurologic manifestations. Am J Dis Child 145:98–101

    Article  CAS  Google Scholar 

  22. Koehler JE, Tappero JW (1993) Bacillary angiomatosis and bacillary peliosis in patients infected with human immunodeficiency virus. Clin Infect Dis 17:612–624

    Article  CAS  Google Scholar 

  23. Welch DF, Hensel RM, Pickett DA et al (1993) Bacteremia due to Rochilimaea henselae in a child: practical identification of isolates in the clinical laboratory. J Clin Microbiol 31:2381–2386

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Harms A, Dehio C (2012) Intruders below the Radar: molecular pathogenesis of Bartonella spp. Clin Microbiol Rev 25:42–78

    Article  CAS  Google Scholar 

  25. Tappero JW, Mohle-Boetani J, Koehler JE et al (1993) The epidemiology of bacillary angiomatosis and bacillary peliosis. JAMA 269:770–775

    Article  CAS  Google Scholar 

  26. Jameson P, Greene C, Regnery R et al (1995) Prevalence of Bartonella henselae antibodies in pet cats through the regions of North America. J Infect Dis 172:1145–1149

    Article  CAS  Google Scholar 

  27. Koehler JE, Glaser CA, Tappero JW (1994) Rochalimaea henselae infection: a new zoonosis with the domestic cat as reservoir. JAMA 271:531–535

    Article  CAS  Google Scholar 

  28. Breitschwerdt E, Kordick DL (2000) Bartonella infection in animals; carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. Clin Microbiol Rev 13:428–438

    Article  CAS  Google Scholar 

  29. Kordick DL, Wilson KH, Sexton DJ et al (1995) Prolonged Bartonella bacteremia in cats associated with cat-scratch disease. J Clin Microbiol 33:3245–3251

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Chomel BB, Abbott RC, Chasten RW et al (1995) Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. J Clin Microbiol 33:2445–2450

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Chomel BB, Kasten RW, Floyd-Hawkins KF et al (1996) Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol 34:1952–1956

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Rolain JM, Franc M, Davoust B, Raoult D (2003) Molecular detection of Bartonella quintana, B. koehlerae, B. henselae, B. clarridgeiae, Rickettsia felis, and Wolbachia pipientis in cat fleas, France. Emerg Infect Dis 9:338–342

    Article  CAS  Google Scholar 

  33. Hamilton DH, Zangwill KM, Hadler JL et al (1995) Cat-scratch disease—Connecticut,1992–1993. J Infect Dis 172:570–573

    Article  CAS  Google Scholar 

  34. Reynolds MG, Homan RC, Curns AT et al (2005) Epidemiology of cat-scratch disease hospitalizations among children in the United States. Pediatr Infect Dis J 24:700–704

    Article  Google Scholar 

  35. Yeh SH, Zangwill KM, Hall B, McPhaul L, Keller M (2000) Parapharyngeal abscess due to cat- scratch disease. Clin Infect Dis 30:599–601

    Article  CAS  Google Scholar 

  36. Arvand M, Schad SG (2006) Isolation of Bartonella henselae DNA from the peripheral blood of a patient with cat scratch disease up to 4 months after the cat scratch injury. J Clin Microbiol 44:2288–2290

    Article  Google Scholar 

  37. Waldvogel K, Regnery R, Anderson BE et al (1994) Disseminated cat-scratch disease: detection Rochalimaea henselae in affected tissue. Eur J Pediatr 153:23–27

    CAS  PubMed  Google Scholar 

  38. Carithers HA (1985) Cat-scratch disease: an overview based on a study of 1200 patients. Am J Dis Child 193:1124–1133

    Article  Google Scholar 

  39. Selby G, Walker GL (1979) Cerebral arteritis in cat-scratch disease. Neurology 29:1413–1418

    Article  CAS  Google Scholar 

  40. Wong M, Isaacs D, Dorney S (1995) Fever, abdominal pain and an intracranial mass. Pediatr Infect Dis J 14:725–728

    Article  CAS  Google Scholar 

  41. Wong MT, Doan MJ, Lattuada CP et al (1995) Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1. Clin Infect Dis 21:352–360

    Article  CAS  Google Scholar 

  42. Roe RH, Michael Jumper J, Fu AD et al (2008) Ocular Bartonella infections. Intl Ophthal Clin 48:93–105

    Article  Google Scholar 

  43. Margileth AM, Wear DJ, English CK (1987) Systemic cat-scratch disease: report of 23 patients with prolonged or recurrent severe bacterial infection. J Infect Dis 155:390–402

    Article  CAS  Google Scholar 

  44. Rappaport DC, Cumming WA, Ros PR (1991) Disseminated hepatic and splenic lesions in cat-scratch disease: imaging features. Am J Roentgenol 156:1227–1228

    Article  CAS  Google Scholar 

  45. Malatack JJ, Jaffe R (1993) Granulomatous hepatitis in three children due to cat-scratch disease without peripheral adenopathy. Am J Dis Child 147:949–953

    Article  CAS  Google Scholar 

  46. Maman E, Bickels J, Ephros M et al (2007) Musculoskeletal manifestations of cat scratch disease. Clin Infect Dis 45:1535–1540

    Article  Google Scholar 

  47. Hajjaji N, Hocqueloux L, Kerdraon R, Bret L (2007) Bone infection in cat-scratch disease: a r eview of the literature. J Infect 54:417–421

    Article  Google Scholar 

  48. Margileth AM, Baehren DF (1998) Chest-wall abscess due to cat-scratch disease (CSD) in an adult with antibodies to Bartonella clarridgeiae: case report and review of the thoracopulmonary manifestations of CSD. Clin Infect Dis 27:353–357

    Article  CAS  Google Scholar 

  49. Myers SA, Prose NS, Garcia JA et al (1992) Bacillary angiomatosis in a child undergoing chemotherapy. J Pediatr 121:574–578

    Article  CAS  Google Scholar 

  50. Malane MS, Laude TA, Chen CK et al (1995) An HIV-1-positive child with fever and a scalp nodule. Lancet 346:1466

    Article  CAS  Google Scholar 

  51. Zarraga M, Rosen L, Herschthal D (2011) Bacillary angiomatosis in an immunocompetent child: a case report and review of the literature. Am J Dermatopath 33:513–515

    Article  Google Scholar 

  52. Ohl ME, Spach DH (2000) Bartonella quintana and urban trench fever. Clin Infect Dis 31:131–135

    Article  CAS  Google Scholar 

  53. Drancourt M, Birtles R, Chaumentin G et al (1996) New serotype of Bartonella henselae in endocarditis and cat-scratch disease. Lancet 347:552–554

    Article  Google Scholar 

  54. Spach DH, Kanter AS, Daniels NA et al (1995) Bartonella (Rochalimaea) species as a cause of apparent “culture-negative” endocarditis. Clin Infect Dis 20:1044–1047

    Article  CAS  Google Scholar 

  55. Drancourt M, Mainardi JL, Brouqui P et al (1995) Bartonella (Rochalimaea) quintana endocarditis in three homeless men. N Engl J Med 332:419–423

    Article  CAS  Google Scholar 

  56. Daly JS, Worthington MG, Brenner DJ et al (1993) Rochalimaea elizabethae sp. nov. isolated from a patient with endocarditis. J Clin Microbiol 31:872–881

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Schwartzman WA, Patnaik M, Barka NE et al (1994) Rochalimaea antibodies in HIV- associated neurologic disease. Neurology 44:1312–1316

    Article  CAS  Google Scholar 

  58. Baker J, Ruiz-Rodriquez R, Whitfield M et al (1995) Bacillary angiomatosis: a treatable cause of acute psychiatric symptoms in human immunodeficiency virus infection. J Clin Psychiatry 56:161–166

    CAS  PubMed  Google Scholar 

  59. Hoey JG, Valois-Cruz F, Goldenberg H et al (2009) Development of an immunoglobulin M capture-based enzyme-linked immunosorbent assay for diagnosis of acute infections with Bartonella henselae. Clin Vaccine Immunol 16:282–284

    Article  CAS  Google Scholar 

  60. Vermeulen MJ, Verbakel H, Notermans DW, Reimerink JH, Peeters MF (2010) Evaluation of sensitivity, specificity and cross-reactivity in Bartonella henselae serology. J Med Microbiol 59:743–745

    Article  Google Scholar 

  61. Metzkor-Colter E, Kletter Y, Avidor B et al (2003) Long-term serological analysis and clinical follow-up of patients with cat scratch disease. Clin Infect Dis 37:1149–1154

    Article  Google Scholar 

  62. Bass JW, Freitas BC, Freitas AD et al (1998) Prospective randomized double blind placebo—controlled evaluation of azithromycin for treatment of cat-scratch disease. Pediatr Infect Dis J 17:447–452

    Article  CAS  Google Scholar 

  63. Zangwill KM (1998) Therapeutic options for cat-scratch disease. Pediatr Infect Dis J 17:1059–1061

    Article  CAS  Google Scholar 

  64. Rolain JM, Brouqui P, Koehler JE et al (2004) Recommendations for treatment of human infections caused by Bartonella species. Antimicrob Agents Chemother 48:1921–1933

    Article  CAS  Google Scholar 

  65. http://www.humanesociety.org/issues/pet_overpopulation/facts/pet_ownership_statistics.html. Accessed 5 Feb 2012

    Google Scholar 

  66. Margileth AM (1968) Cat scratch disease: nonbacterial regional lymphadenitis. The study of 145 patients and a review of the literature. Pediatrics 42(5):803–818 (http://www.ncbi.nlm.nih.gov/pubmed/4972192)

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Los Angeles, USA

    Kenneth M. Zangwill

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  1. Kenneth M. Zangwill
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Correspondence to Kenneth M. Zangwill .

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Editors and Affiliations

  1. Royal Children's Hospital, Dept. Pediatrics, University of Melbourne, Flemington Road, Parkville, 3052, Victoria, Australia

    Nigel Curtis

  2. Institute of Child Life and Health, UBHT Education Centre, University of Bristol, Upper Maudlin Street, Bristol, BS28AE, UK

    Adam Finn

  3. University of Oxford, Level 4,John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Andrew J. Pollard

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Zangwill, K. (2013). Cat Scratch Disease and Other Bartonella Infections. In: Curtis, N., Finn, A., Pollard, A. (eds) Hot Topics in Infection and Immunity in Children IX. Advances in Experimental Medicine and Biology, vol 764. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4726-9_13

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