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Immunoglobulins in Mammary Secretions

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Advanced Dairy Chemistry

Abstract

Immunoglobulins secreted in colostrum and milk by the lactating mammal are major factors providing immune protection to the newborn. Immunoglobulins in mammary secretions represent the cumulative immune response of the lactating animal to exposure to antigenic stimulation that occurs through interaction with the environment. Extensive species variability exists in how and when maternal immunoglobulins are transferred to the neonate. In addition, there is a range of mechanisms by which the transferred immunoglobulins may play a protective role in the neonate. This chapter reviews the immunoglobulins found in mammary secretions in the context of their diversity of structure, origin, mechanisms of transfer, and function.

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References

  • Ahouse, J.J., Hagerman, C.L., Mittal, P., Gilbert, D.J., Copeland, N.G., Jenkins, N.A. and Simister, N.E. (1993). A mouse MHC class-I-like Fc receptor encoded outside the MHC. J. Immunol. 151, 6076–6088.

    CAS  Google Scholar 

  • Alisky, J. (2009). Bovine and human-derived passive immunization could help slow a future avian influenza pandemic. Med. Hypotheses, 72, 74–75.

    Article  CAS  Google Scholar 

  • Anthony, R.M. and Ravetch, J.V. (2010). A novel role for the IgG glycan: the anti-inflammatory activity of sialylated IgG Fcs. J. Clin. Immunol. 30, S9–S14.

    Article  CAS  Google Scholar 

  • Aynaud, J.M., Bernard, S., Bottreau, E., Lantier, I., Salmon, H. and Vannier, P. (1991). Induction of lactogenic immunity to transmissible gastroenteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract. Vet. Microbiol. 26, 227–239.

    Article  CAS  Google Scholar 

  • Barrington, G.M. and Parish, S.M. (2001). Bovine neonatal immunology. Vet. Clin. North Am. Food Anim. Pract. 17, 463–475.

    CAS  Google Scholar 

  • Barrington, G.M., Besser, T.E., Davis, W.C., Gay, C.C., Reeves, J.J. and McFadden, T.B. (1997). Expression of immunoglobulin G1 receptors by bovine mammary epithelial cells and mammary leukocytes. J. Dairy Sci. 80, 86–93.

    Article  CAS  Google Scholar 

  • Barrington, G.M., Besser, T.E., Gay, C.C., Davis, W.C., Reeves, J.J. and McFadden, T.B. (1997). Effect of prolactin on in vitro expression of the bovine mammary immunoglobulin G1 receptor. J. Dairy Sci. 80, 94–100.

    Article  CAS  Google Scholar 

  • Baumrucker, C.R., Burkett, A.M., Magliaro-Macrina, A.L. and Dechow, C.D. (2009). Colostrogenesis: mass transfer of immunoglobulin G1 into colostrum. J. Dairy Sci. 93, 3031–3038.

    Article  CAS  Google Scholar 

  • Bazin, H., Beckers, A. and Querinjean, P. (1974). Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, and IgG1, IgG2a, IgG2b, IgG2c. Eur. J. Immunol. 4, 44–48.

    Article  CAS  Google Scholar 

  • Bender, B., Bodrogi, L., Mayer, B., Schneider, Z., Zhao, Y., Hammarstrom, L., Eggen, I. and Bosze, Z. (2007). Position independent and copy-number-related expression of the neonatal Fc receptor α-chain in transgenic mice carrying a 102 kb genomic fragment. Transgenic Res. 16, 613–627.

    Article  CAS  Google Scholar 

  • Bernhisel-Broadbent, J., Yolken, R.H. and Sampson, H.A. (1991). Allergenicity of orally administered preparations in food-allergic children. Pediatrics 87, 208–214.

    CAS  Google Scholar 

  • Bikker, P., Kranendonk, G., Gerritsen, R., Russell, L., Campbell, J., Crenshaw, J., Rodriguez, C., Rodenas, J. and Polo, J. (2010). Absorption of orally supplied immunoglobulins in neonatal piglets. Livest. Sci. 134, 139–142.

    Article  Google Scholar 

  • Blum, J.W. (2003). Colostrum—more than just an immunoglobulin supplier. Acta Vet. Scand. 98(Suppl.), 123–124.

    Google Scholar 

  • Blum, J.W. (2006). Nutritional physiology of neonatal calves. J. Anim. Physiol. Anim. Nutr. 90, 1–11.

    Article  CAS  Google Scholar 

  • Bovine Alliance on Management and Nutrition. (1995). A Guide to Colostrum and Colostrum Management for Dairy Calves. American Feed Industry Associates, Arlington.

    Google Scholar 

  • Braathen, R., Hohman, V.S., Brandtzaeg, P. and Johansen, F.E. (2007). Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians. J. Immunol. 178, 1589–1597.

    CAS  Google Scholar 

  • Brambell, F.W.R. (1970). The Transmission of Passive Immunity from Mother to Young. North-Holland, Amsterdam.

    Google Scholar 

  • Brandtzaeg, P. (1985). Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand. J. Immunol. 22, 111–146.

    Article  CAS  Google Scholar 

  • Brandtzaeg, P. (2003). Mucosal immunity: integration between mother and the breast-fed infant. Vaccine, 21, 3382–3388.

    Article  CAS  Google Scholar 

  • Brandtzaeg, P. (2010). The mucosal immune system and its integration with the mammary glands. J. Pediatr. 156, S8–S15.

    Article  CAS  Google Scholar 

  • Brandtzaeg, P. and Johansen, F.-E. (2007). IgA and intestinal homeostasis, in, Mucosal Immune Defense: Immunoglobulin A, C.S. Kaetzel, ed., Springer, New York. pp. 221–268.

    Google Scholar 

  • Brock, J.H., Arzabe, F.R., Ortega, F. and Pineiro, A. (1977). The effect of limited proteolysis by trypsin and chymotrypsin on bovine colostral IgG1. Immunology, 32, 215–219.

    CAS  Google Scholar 

  • Burmeister, W.P., Huber, A.H. and Bjorkman, P.J. (1994). Crystal structure of the complex between the rat neonatal Fc receptor and Fc. Nature 372, 379–383.

    Article  CAS  Google Scholar 

  • Butler, J.E. (1974). Immunoglobulins of the mammary secretions, in Lactation: A Comprehensive Treatise, Vol. 3, B.L. Larson and V.R. Smith, eds., Academic, New York. pp. 217–255.

    Google Scholar 

  • Butler, J.E. (1981). Concept of humoral immunity among ruminants, in, The Ruminant Immune System, Volume 137 in Series Advances in Experimental Biology and Medicine, J.E. Butler, ed., Plentum Press, New York. pp. 3–55.

    Article  CAS  Google Scholar 

  • Butler, J.E. (1983). Bovine immunoglobulins: an augmented review. Vet. Immunol. Immunopathol. 4, 43–152.

    Article  CAS  Google Scholar 

  • Butler, J.E. (1986). Biochemistry and biology of ruminant immunoglobulins, in, Progress in Veterinary Microbiology and Immunology, R. Pandey, ed., Karger AG, Basel. pp. 1–53.

    Google Scholar 

  • Butler, J.E. (1998). Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals. Rev. Sci. Tech. 17, 43–70.

    CAS  Google Scholar 

  • Butler, J.E. and Kehrli, M.E., Jr. (2005). Immunoglobulins and immunocytes in the mammary gland and its secretions, in, Mucosal Immunology, 3rd edn., Vol. 2, J. Mestecky, M. Lamm, W. Strober, J. Bienenstock, J.R. McGhee and L. Mayer, eds., Elsevier, Amsterdam. pp. 1764–1793.

    Google Scholar 

  • Caffin, J.P. and Poutrel, B. (1988). Physiological and pathological factors influencing bovine immunoglobulin G2 concentration in milk. J. Dairy Sci. 71, 2035–2043.

    Article  CAS  Google Scholar 

  • Calmettes, P., Cser, L. and Rajnavolgy, E. (1991). Temperature and pH dependence of immunoglobulin G conformation. Arch. Biochem. Biophys. 291, 277–283.

    Article  CAS  Google Scholar 

  • Campbell, B. and Petersen, W.E. (1963). Immune milk—a historical survey. Dairy Sci. Abstr. 25, 345–358.

    Google Scholar 

  • Cervenak, J. and Kacskovics, I. (2009). The neonatal Fc receptor plays a crucial role in the metabolism of IgG in livestock animals. Vet. Immunol. Immunopathol. 128, 171–177.

    Article  CAS  Google Scholar 

  • Chen, C.-C. and Chang, H.-M. (1998). Effect of thermal protectants on the stability of bovine milk immunoglobulin G. J. Agric. Food Chem. 46, 3570–3576.

    Article  CAS  Google Scholar 

  • Chen, C.-C., Tu, Y.-Y. and Chang, H.-M. (2000). Thermal stability of bovine milk immunoglobulin G (IgG) and the effect of added thermal protectants on the stability. J. Food Sci. 65, 188–193.

    Article  CAS  Google Scholar 

  • Chernishov, V.P. and Slukvin, I.I. (1990). Mucosal immunity of the mammary gland and immunology of mother/newborn interrelation. Arch. Immunol. Ther. Exp. (Warsz.), 38, 145–164.

    CAS  Google Scholar 

  • Chrony, A., Puga, I. and Cerutti, A. (2010). Innate signaling networks in mucosal IgA class switching. Adv. Immunol. 107, 31–69.

    Article  Google Scholar 

  • Cianga, P., Medesan, C., Richardson, J.A., Ghetie, V. and Ward, E.S. (1999). Identification and function of neonatal Fc receptor in mammary gland of lactating mice. Eur. J. Immunol. 29, 2515–2523.

    Article  CAS  Google Scholar 

  • Colker, C.M., Swain, M., Lynch, L. and Gingerich, D.A. (2002). Effects of a milk-based bioactive micronutrient beverage on pain symptoms and activity of adults with osteoarthritis: a double-blind, placebo-controlled clinical evaluation. Nutrition, 18, 388–392.

    Article  CAS  Google Scholar 

  • Cordle, C.T., Schaller, J.P., Winship, T.R., Candler, E.L., Hilty, M.D., Smith, K.L., Saif, L.J., Kohler, E.M. and Krakowska, S. (1991). Passive immune protection from diarrhea caused by rotavirus or E. coli: an animal model to demonstrate and quantitate efficacy. Adv. Exp. Med. Biol. 310, 317–327.

    Article  CAS  Google Scholar 

  • Danielsen, M., Pedersen, L.J. and Bendixen, E. (2010). An in vivo characterization of colostrum protein uptake in porcine gut during early lactation. J. Proteomics, 74, 101–109.

    Article  CAS  Google Scholar 

  • Darton, P.J. and McDowell, G.H. (1980). Selective transfer of IgG1 into milk of ewes following inhibition of milk secretion or acute inflammation. Aust. J. Exp. Biol. Med. Sci. 58, 149–157.

    Article  CAS  Google Scholar 

  • Davids, B.J., Palm, J.E.D., Housley, M.P., Smith, J.R., Anderson, Y.S., Martin, M.G., Hendrickson, B.A., Johansen, F.-E., Svard, S.G., Gillin, F.D. and Eckmann, L. (2006). Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia. J. Immunol. 177, 6281–6290.

    CAS  Google Scholar 

  • Davidson, G.P. (1996). Passive protection against diarrhea disease. J. Pediatr. Gastroenterol. Nutr. 23, 207–212.

    Article  CAS  Google Scholar 

  • Davis, C.L. and Drackley, J.K. (1998). The Development, Nutrition, and Management of the Young Calf. Iowa State University Press, Ames.

    Google Scholar 

  • de Rham, O. and Isliker, H. (1977). Proteolysis of bovine immunoglobulins. Int. Arch. Allergy Appl. Immunol. 55, 61–69.

    Article  Google Scholar 

  • DeNise, S.K., Robison, J.D., Stott, G.H. and Armstrong, D.V. (1989). Effects of passive immunity on subsequent production in dairy heifers. J. Dairy Sci. 72, 552–554.

    Article  CAS  Google Scholar 

  • Devery-Pocius, J.E. and Larson, B.L. (1983). Age and previous lactations as factors in the amount of colostral immunoglobulins. J. Dairy Sci. 67, 2701–2710.

    Google Scholar 

  • Devillers, N., van Milgen, J., Prunier, A. and Le Dividich, J. (2004). Estimation of colostrum intake in the neonatal pig. Anim. Sci. 78, 305–313.

    CAS  Google Scholar 

  • Dickinson, B.L., Badizadegan, K., Wu, Z., Ahouse, J.C., Zhu, X., Simister, N.E., Blumberg, R.S. and Lencer, W.I. (1999). Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J. Clin. Invest. 104, 903–911.

    Article  CAS  Google Scholar 

  • Dominguez, E., Perez, M.D. and Calvo, M. (1997). Effect of heat treatment on the antigen-binding activity of anti-peroxidase immunoglobulin in bovine colostrum. J. Dairy Sci. 80, 3182–3187.

    Article  CAS  Google Scholar 

  • Dominguez, E., Perez, M.D., Puyol, P., Sanchez, L. and Calvo, M. (2001). Effect of pH on antigen-binding activity of IgG from bovine colostrum upon heating. J. Dairy Res. 68, 511–518.

    Article  CAS  Google Scholar 

  • Donovan, G.A., Badinga, L., Collier, R.J., Wilcox, C.J. and Braun, R.K. (1986). Factors influencing passive transfer in dairy calves. J. Dairy Sci. 69, 754–759.

    Article  CAS  Google Scholar 

  • Eigel, W.N., Butler, J.E., Ernstrom, C.A., Farrell, H.M., Jr., Harwalkar, V.R., Jenness, R. and Whitney, R.M.L. (1984). Nomenclature of proteins of cow’s milk: fifth revision. J. Dairy Sci. 67, 1599–1631.

    Article  CAS  Google Scholar 

  • Elizondo-Salazar, J.A., Jayarao, B.M. and Heinrichs, A.J. (2010). Effect of heat treatment of bovine colostrum on bacterial counts, viscosity, and immunoglobulin G concentration. J. Dairy Sci. 93, 961–967.

    Article  CAS  Google Scholar 

  • Facon, M., Skura, B.J. and Nakai, S. (1993). Potential for immunological supplementation of foods. Food. Agric. Immunol. 5, 85–91.

    Article  CAS  Google Scholar 

  • Fang, W.D. and Mukkur, T.K.S. (1976). Physicochemical characteristics of proteolytic cleavage fragments of bovine colostral immunoglobulin G1 (IgG1). Biochem. J. 155, 25–30.

    CAS  Google Scholar 

  • Farmer, C. and Quesnel, H. (2009). Nutritional, hormonal, and environmental effects on colostrum in sows. J. Anim. Sci. 87, 56–64.

    Article  CAS  Google Scholar 

  • Fernandez, M.I., Pedron, T., Tournebize, R., Olivo-Marin, J.-C., Sansonetti, P.J. and Phalipon, A. (2003). Anti-inflammatory role for intracellular dimeric immunoglobulin A by neutralization of lipopolysaccharide in epithelial cells. Immunity 18, 739–749.

    Article  CAS  Google Scholar 

  • Frenyo, V.L., Butler, J.E. and Guidry, A.J. (1986). The association of extrinsic bovine IgG1, IgG2, SIgA and IgM with the major fractions and cells of milk. Vet. Immunol. Immunopathol. 13, 239–254.

    Article  CAS  Google Scholar 

  • Fuchs, R. and Ellinger, I. (2004). Endocytic and trans­cytotic processes in villus syncytiotrophoblast: role in nutrient transport to the human fetus. Traffic 5, 725–738.

    Article  CAS  Google Scholar 

  • Fukumoto, L.R., Skura, B.J. and Nakai, S. (1994). Stability of membrane-sterilized bovine immunoglobulins aseptically added to UHT milk. J. Food Sci. 59, 757–762.

    Article  CAS  Google Scholar 

  • Gao, W., Chen, L., Xu, L.B. and Huang, X.H. (2010). Specific activity against diarrheagenic bacteria in bovine immune milk and effect of pH on its antigen-binding activity upon heating. J. Dairy Res. 77, 220–224.

    Article  CAS  Google Scholar 

  • Gapper, L.W., Copstake, D.E.J., Otter, D.E. and Indyk, H.E. (2007). Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a review. Anal. Bioanal. Chem. 389, 93–109.

    Article  CAS  Google Scholar 

  • Ghetie, V. and Ward, E.S. (1997). FcRn: the MHC class I-related receptor that is more than an IgG transporter. Immunol. Today 18, 592–598.

    Article  CAS  Google Scholar 

  • Gilbert, R.P., Gaskins, C.T., Hillers, J.K., Brinks, J.S. and Denham, A.H. (1988). Inbreeding and immunoglobulin G1 concentrations in cattle. J. Anim. Sci. 66, 2490–2497.

    CAS  Google Scholar 

  • Gill, H. (2003). Dairy products and the immune function in the elderly, in, Functional Dairy Products, T. Mattila-Sandholm and M. Saarela, eds., CRC, New York. pp. 133–168

    Google Scholar 

  • Gingerich, D.A. and McPhillips, C.A. (2005). Analytical approach to determination of safety of milk ingredients from hyperimmunized cows. Regul. Toxicol. Pharmacol. 41, 102–112.

    Article  CAS  Google Scholar 

  • Glass, R.I., Svennerholm, A.-M., Stoll, B.J., Khan, M.R., Hossain, K.M.B., Huq, M.I. and Holmgren, J. (1983). Protection against cholera in breast-fed children by antibodies in breast milk. N. Engl. J. Med. 398, 1389–1392.

    Article  Google Scholar 

  • Godden, S.M., Smith, S., Feirtag, J.M., Green, L.R., Wells, S.J. and Fetrow, J.P. (2003). Effect of on-farm commercial batch pasteurization of colostrum on colostrum and serum immunoglobulin concentrations in dairy calves. J. Dairy Sci. 86, 1503–1512.

    Article  CAS  Google Scholar 

  • Godden, S., McMartin, S., Feirtag, J., Stabel, J., Bey, R., Goyal, S., Metzger, L., Fetrow, J., Wells, S. and Chester-Jones, H. (2006). Heat-treatment of bovine colostrum. II: effects of heating duration on pathogen viability and immunoglobulin G. Dairy Sci. 89, 3476–3483.

    CAS  Google Scholar 

  • Goldman, A.S. (1993). The immune system of human milk: antimicrobial, antiinflammatory and immunomodulating properties. Pediatr. Infect. Dis. J. 12, 664–671.

    Article  CAS  Google Scholar 

  • Goldman, A.S. and Ogra, P.L. (1999). Anti-infectious and infectious agents in human milk, in, Mucosal Immunology, 2nd edn., P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock and J.R. McGhee, eds., Academic, New York. pp. 1511–1521.

    Google Scholar 

  • Goldsmith, S.J., Dickson, J.S., Barnhart, H.M., Toledo, R.T. and Eitenmiller, R.R. (1983). IgA, IgG, IgM and lactoferrin contents of human milk during early lactation and the effect of processing and storage. J. Food Prot. 46, 4–7.

    CAS  Google Scholar 

  • Guarner, F. and Malagelada, J.-R. (2003). Gut flora in health and disease. Lancet 361, 512–519.

    Article  Google Scholar 

  • Guidry, A.J. and Miller, R.H. (1986). Immunoglobulin isotype concentrations in milk as affected by stage of lactation and parity. J. Dairy Sci. 69, 1799–1805.

    Article  CAS  Google Scholar 

  • Guidry, A.J., Butler, J.E., Pearson, R.E. and Weiland, B. (1980). IgA, IgG1, IgG2, IgM and BSA secretion by the bovine mammary gland throughout lactation. Vet. Immunol. Immunopathol. 1, 329–341.

    Article  CAS  Google Scholar 

  • Guy, M.A., McFadden, T.B., Cockrell, D.C. and Besser, T.E. (1994). Effects of unilateral prepartum milking on concentrations of immunoglobulin G1 and prolactin in colostrum. J. Dairy Sci. 77, 3584–3591.

    Article  CAS  Google Scholar 

  • Hanson, L.A., Silfverdal, S.-A., Stromback, L., Erling, V., Zaman, S., Olcen, P. and Telemo, E. (2001). The immunological role of breast feeding. Pediatr. Allergy Immunol. 12(Suppl. 14), 15–19.

    Article  Google Scholar 

  • Hanson, L.A., Korotkova, M. and Telemo, E. (2005). Human milk: its components and their immunobiologic functions, in, Mucosal Immunology, 3rd edn., Vol. 2, J. Mestecky, M. Lamm, W. Strober, J. Bienenstock, J.R. McGhee and L. Mayer, eds., Elsevier, Amsterdam. pp. 1795–1827

    Google Scholar 

  • Harmon, R.J., Schanbacher, F.L., Ferguson, L.C. and Smith, K.L. (1976). Changes in lactoferrin, immunoglobulin G, bovine serum albumin, and α-lactalbumin during acute experimental and natural coliform mastitis in cows. Infect. Immun. 13, 533–542.

    CAS  Google Scholar 

  • He, W., Ladinsky, M.S., Huey-Tubman, K.E., Jensen, G.J., McIntosh, R. and Bjorkman, P.J. (2008). FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 455, 542–546.

    Article  CAS  Google Scholar 

  • Heddle, R.J. and Rowley, D. (1975). Dog immunoglobulins. I. Immunochemical characterization of dog serum, parotid saliva, colostrum, milk and small bowel fluid. Immunology 29, 185–195.

    Google Scholar 

  • Huang, X.H., Chen, L., Gao, W., Zhang, W., Chen, S.J., Xu, L.B. and Zhang, S.Q. (2008). Specific IgG activity of bovine immune milk against diarrhea bacteria and its protective effects on pathogen-infected intestinal damages. Vaccine 26, 5973–5980.

    Article  CAS  Google Scholar 

  • Hunziker, W. and Kraehenbuhl, J.-P. (1998). Epithelial transcytosis of immunoglobulins. J. Mammary Gland Biol. Neoplasia. 3, 287–302.

    Article  CAS  Google Scholar 

  • Hurley, W.L. and Theil, P.K. (2011). Perspectives on immunoglobulins in colostrum and milk. Nutrients 3, 442–474.

    Article  CAS  Google Scholar 

  • Husband, A.J. (1985). Mucosal immune interactions in intestine, respiratory tract and mammary gland. Prog. Vet. Microbiol. Immunol. 1, 25–57.

    CAS  Google Scholar 

  • Husband, A.J., Brandon, M.R. and Lascelles, A.K. (1972). Absorption and endogenous production of immunoglobulins in calves. Aust. J. Exp. Biol. Med. Sci. 50, 491–498.

    Article  CAS  Google Scholar 

  • Ishikawa, H., Kanamori, Y., Hamada, H. and Kiyono, H. (2005). Development and function of organized gut-associated lymphoid tissues, in, Mucosal Immunology, 3rd ed., Vol. 1, J. Mestecky, M. Lamm, W. Strober, J. Bienenstock, J.R. McGhee and L. Mayer, eds., Elsevier, Amsterdam. pp. 385–405.

    Google Scholar 

  • Israel, E.J., Taylor, S., Wu, Z., Mizoguchi, E., Blumberg, R.S., Bhan, A. and Simister, E. (1997). Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology 92, 69–74.

    Article  CAS  Google Scholar 

  • Iwasaki, A. (2007). Mucosal dendritic cells. Annu. Rev. Immunol. 25, 381–418.

    Article  CAS  Google Scholar 

  • Jarchum, I. and Pamer, E.C. (2011). Regulation of innate and adaptive immunity by the commensal microbiota. Curr. Opin. Immunol. 23, 1–8.

    Article  CAS  Google Scholar 

  • Jenkins, M.C., O’Brien, C., Trout, J., Guidry, A. and Fayer, R. (1999). Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult mice. Vaccine 17, 2453–2460.

    Article  CAS  Google Scholar 

  • Jensen, A.R., Elnif, J., Burrin, D.G. and Sangild, P.T. (2001). Development of intestinal immunoglobulin absorption and enzyme activity in neonatal pigs is diet dependent. J. Nutr. 131, 3259–3265.

    CAS  Google Scholar 

  • Johansen, F.E., Braathen, R. and Brandtzaeg, P. (2000). Role of J chain in secretory immunoglobulin formation. Scand. J. Immunol. 52, 240–248.

    Article  CAS  Google Scholar 

  • Johansen, F.E., Braathen, R. and Brandtzaeg, P. (2001). The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgA. J. Immunol. 167, 5185–5192.

    CAS  Google Scholar 

  • Junghans, R.P. (1997). Finally! The Brambell receptor (FcRB). Immunol. Res. 16, 29–57.

    Article  CAS  Google Scholar 

  • Junghans, R.P. and Anderson, C.L. (1996). The protection receptor for IgG catabolism is the β2-microglobulin-containing neonatal intestinal transport receptor. Proc. Natl. Acad. Sci. U.S.A. 93, 5512–5516.

    Article  CAS  Google Scholar 

  • Kacskovics, I. (2004). Fc receptors in livestock species. Vet. Immunol. Immunopathol. 102, 351–362.

    Article  CAS  Google Scholar 

  • Kaetzel, C.S. and Bruno, M.E.C. (2007). Epithelial transport of IgA by the polymeric immunoglobulin receptor, in, Mucosal Immune Defense: Immunoglobulin A, C.S. Kaetzel, ed., New York: Springer. pp. 43–89

    Google Scholar 

  • Kelsall, B. and Strober, W. (1999). Gut-associated lymphoid tissue: antigen handling and T-lymphocyte responses, in, Mucosal Immunology, 2nd edn., P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock and J.R. McGhee, eds., Academic, New York. pp. 293–317.

    Google Scholar 

  • Kobayashi, K., Ogata, H., Morikawa, M., Iijima, S., Harada, N., Yoshida, T., Brown, W.R., Inoue, N., Hamada, Y., Ishii, H., Watanabe, M. and Hibi, T. (2002). Distribution and partial characterization of IgG Fc binding protein in various mucin producing cells and body fluids. Gut 51, 169–176.

    Article  CAS  Google Scholar 

  • Korhonen, H., Marnila, P. and Gill, H.S. (2000a). Milk immunoglobulins and complement factors. Br. J. Nutr. 84(Suppl. 1), S75–S80.

    CAS  Google Scholar 

  • Korhonen, H., Marnila, P. and Gill, H.S. (2000b). Bovine milk antibodies for health. Br. J. Nutr. 84(Suppl. 1), S135–S146.

    CAS  Google Scholar 

  • Kortbeek-Jacobs, J.M.C., van Kooten, P.J.S., van der Donk, J.A., van Dijk, J.E. and Rutten, V.P. (1984). The effect of oral immunization on the population of lymphocytes migrating to the mammary gland of the sow. Vet. Microbiol. 9, 287–299.

    Article  CAS  Google Scholar 

  • Koutras, A.K. and Vigorita, V.J. (1989). Fecal secretory immunoglobulin A in breast milk versus formula feeding in early infancy. J. Pediatr. Gastroenterol. Nutr. 9, 58–61.

    CAS  Google Scholar 

  • Lanza, I., Shoup, D.I. and Saif, L.J. (1995). Lactogenic immunity and milk antibody isotypes to transmissible gastroenteritis virus in sows exposed to porcine respiratory coronavirus during pregnancy. Am. J. Vet. Res. 56, 739–748.

    CAS  Google Scholar 

  • Larson, B.L. (1985). Biosynthesis and cellular secretion of milk, in, Lactation, B.L. Larson, ed., Iowa State University Press, Ames. pp. 155–163.

    Google Scholar 

  • Larson, B.L. (1992). Immunoglobulins of the mammary secretions, in, Advanced Dairy Chemistry. Proteins, Volume 2, P.F. Fox, ed., Elsevier Applied Science, London. pp. 231–254.

    Google Scholar 

  • Larson, B.L., Heary, H.L., Jr. and Devery, J.E. (1980). Immunoglobulin production and transport by the mammary gland. J. Dairy Sci. 63, 665–671.

    Article  CAS  Google Scholar 

  • Lascelles, A.K. (1963). A review of the literature on some aspects of immune milk. Dairy Sci. Abstr. 25, 359–364.

    Google Scholar 

  • Le Dividich, J., Rooke, J.A. and Herpin, P. (2005). Nutritional and immunological importance of colostrum for the new-born pig. J. Agric. Sci. 143, 469–485.

    Article  CAS  Google Scholar 

  • Le Dividich, J., Marion, J. and Thomas, F. (2007). Energy and nitrogen utilisation of sow colostrum and milk by the piglet. Can. J. Anim. Sci. 87, 571–577.

    Article  Google Scholar 

  • Leary, H.L., Jr., Larson, B.L. and Nelson, D.R. (1982). Immunohistochemical localization of IgG1 and IgG2 in prepartum lactating bovine mammary tissue. Vet. Immunol. Immunopathol. 3, 509–514.

    Article  CAS  Google Scholar 

  • Levine, M.M. (1991). Vaccines and milk immunoglobulin concentrates for prevention of infectious diarrhea. J. Pediatr. 118, S129–S136.

    Article  CAS  Google Scholar 

  • Li-Chan, E., Kummer, A., Loso, J.N., Kitts, D.D. and Nakai, S. (1995). Stability of bovine immunoglobulins to thermal treatment and processing. Food Res. Int. 28, 9–16.

    Article  CAS  Google Scholar 

  • Lilius, E.-M. and Marnila, P. (2001). The role of colostral antibodies in prevention of microbial infections. Curr. Opin. Infect. Dis. 14, 295–300.

    Article  CAS  Google Scholar 

  • Lin, C., Mahan, D.C., Wu, G. and Kim, S.W. (2009). Protein digestibility of porcine colostrum by neonatal pigs. Livest. Sci. 121, 182–186.

    Article  Google Scholar 

  • Lindstrom, P., Paulsson, M., Nylander, T., Elofsson, U. and Lindmark-Månsson, H. (1994). The effect of heat treatment on bovine immunoglobulins. Milchwissenschaft 49, 67–71.

    CAS  Google Scholar 

  • Liongue, C., John, L.B. and Ward, A.C. (2011). Origins of adaptive immunity. Crit. Rev. Immunol. 31, 61–71.

    Article  CAS  Google Scholar 

  • Lonnerdal, B. (2003). Nutritional and physiological significance of human milk proteins. Am. J. Clin. Nutr. 77, 1537S–1543S.

    Google Scholar 

  • Lu, W., Zhao, Z., Zhao, Y., Yu, S., Zhao, Y., Fan, B., Kasckovics, I., Hammarstrom, L. and Li, N. (2007). Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology 122, 401–408.

    Article  CAS  Google Scholar 

  • Mahe, S., Huneau, J.-F., Marteau, P., Thuille, F. and Tome, D. (1992). Gastroileal nitrogen and electrolyte movements after bovine milk ingestion in humans. Am. J. Clin. Nutr. 56, 410–416.

    CAS  Google Scholar 

  • Mainer, G., Sanchez, L., Ena, J.M. and Calvo, M. (1997). Kinetic and thermodynamic parameters for heat denaturation of bovine milk IgG, IgA and IgM. J. Food Sci. 62, 1034–1038.

    Article  CAS  Google Scholar 

  • Marchalonis, J.J., Schluter, S.F., Bernstein, R.M., Shen, S. and Edmundson, A.B. (1998). Phylogenetic emergence and molecular evolution of the immunoglobulin family. Adv. Immunol. 70, 417–506.

    Article  CAS  Google Scholar 

  • Maul, R.W. and Gearhart, P.J. (2010). Controlling somatic hypermutation in immunoglobulin variable and switch regions. Immunol. Res. 47, 113–122.

    Article  CAS  Google Scholar 

  • Maxson, R.T., Johnson, D.D., Jackson, R.J. and Smith, S.D. (1996). The protective role of enteral IgA supplementation in neonatal gut-origin sepsis. Ann. N.Y. Acad. Sci. 778, 405–407.

    Article  CAS  Google Scholar 

  • McClelland, D.B.L. (1982). Antibodies in milk. J. Reprod. Fertil. 65, 537–543.

    Article  CAS  Google Scholar 

  • McFadden, T.B., Besser, T.E. and Barrington, G.M. (1997). Regulation of immunoglobulin transfer into mammary secretions of ruminants, in, Milk Composition, Production and Biotechnology, R.A.S. Welch, D.J.W. Burns, S.R. Davis, A.I. Popay and C.G. Prosser, eds., CAB International, New York. pp. 133–152.

    Google Scholar 

  • McGhee, J.R., Michalek, S.M. and Ghanta, V.K. (1975). Rat immunoglobulins in serum and secretions: purification of rat IgM, IgA and IgG and their quantitation in serum, colostrum, milk and saliva. Immunochemistry 12, 817–823.

    Article  CAS  Google Scholar 

  • McGuire, T.C. and Crawford, T.B. (1972). Identification and quantitation of equine serum and secretory immunoglobulin A. Infect. Immun. 6, 610–615.

    CAS  Google Scholar 

  • McMartin, S., Godden, S., Metzger, L., Feirtag, J., Bey, R., Stabel, J., Goyal, S., Fetrow, J., Wells, S. and Chester-Jones, H. (2006). Heat treatment of bovine colostrum. I: effects of temperature on viscosity and immunoglobulin G level. J. Dairy Sci. 89, 2110–2118.

    CAS  Google Scholar 

  • Mehta, R. and Petrova, A. (2010). Biologically active breast milk proteins in association with very preterm delivery and stage of lactation. J. Perinatol. 31, 58–62.

    Article  CAS  Google Scholar 

  • Mestecky, J. and Russell, M.W. (1998). Passive and active protection against disorders of the gut. Vet. Q. 20, S83–S87.

    Article  Google Scholar 

  • Mestecky, J., Moro, I. and Underdown, B.J. (1999). Mucosal immunoglobulins, in, Mucosal Immunology, 2nd edn., P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock and J.R. McGhee, eds. Academic, New York. pp. 133–152.

    Google Scholar 

  • Meyer, A., Parng, C.-L., Hansal, S.A., Osborne, B.A. and Goldsby, R.A. (1997). Immunoglobulin gene diversification in cattle. Int. Rev. Immunol. 15, 165–183.

    Article  CAS  Google Scholar 

  • Michalek, S.M., Rahman, A.F.R. and McGhee, J.R. (1975). Rat immunoglobulins in serum and colostrum: comparison of IgM, IgA and IgG in serum, colostrum, milk and saliva of protein malnourished and normal rats. Proc. Soc. Exp. Biol. Med. 148, 1114–1118.

    CAS  Google Scholar 

  • Mix, E., Goertsches, R. and Zettl, U.K. (2006). Immunoglobulins—basic considerations. J. Neurol. 253, V/9–V/17.

    Google Scholar 

  • Moon, H.W. and Bunn, T.O. (1993). Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals. Vaccine, 1, 213–220.

    Article  Google Scholar 

  • Morton, H.C., van Egmond, M. and van de Winkel, J.G.J. (1996). Structure and function of human IgA Fc receptors (FcαR). Crit. Rev. Immunol. 16, 423–440.

    CAS  Google Scholar 

  • Moser, M. and Leo, O. (2010). Key concepts in immunology. Vaccine, 28S, C2–C13.

    Article  CAS  Google Scholar 

  • Mostov, K.E. (1994). Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12, 63–84.

    Article  CAS  Google Scholar 

  • Mostov, K. and Kaetzel, C.S. (1999). Immunoglobulin transport and the polymeric immunoglobulin receptor, in, Mucosal Immunology, 2nd edn., Academic, New York. pp. 181–211.

    Google Scholar 

  • Muller, L.D. and Ellinger, D.K. (1981). Colostral immunoglobulin concentrations among breeds of dairy cattle. J. Dairy Sci. 64, 1727–1730.

    Article  CAS  Google Scholar 

  • Newburg, D.S. and Walker, W.A. (2007). Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr. Res. 61, 2–8.

    Article  CAS  Google Scholar 

  • Newstead, D.F. (1976). Carotene and immunoglobulin concentrations in the colostrum and milk of pasture-fed cows. J. Dairy Res. 43, 229–237.

    Article  CAS  Google Scholar 

  • Nickerson, S.C. and Heald, C.W. (1982). Cells in local reaction to experimental Staphylococcus aureus infection in bovine mammary gland. J. Dairy Sci. 65, 105–116.

    Article  CAS  Google Scholar 

  • Nisonoff, A., Wissler, F.C., Lipman, L.N. and Woernley, D.L. (1960). Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds. Arch. Biochem. Biophys. 89, 230–244.

    Article  CAS  Google Scholar 

  • Nocek, J.E., Braund, D.G. and Warner, R.G. (1984). Influence of neonatal colostrum administration, immunoglobulin, and continued feeding of colostrum on calf gain, health, and serum protein. J. Dairy Sci. 67, 319–333.

    Article  CAS  Google Scholar 

  • Norman, L.M. and Hohenboken, W.D. (1981). Genetic differences in concentration of immunoglobulins G1 and M in serum and colostrum of cows and in serum of neonatal calves. J. Anim. Sci. 53, 1465–1472.

    CAS  Google Scholar 

  • Oyeniyi, O.O. and Hunter, A.G. (1978). Colostral constituents including immunoglobulins in the first three milkings postpartum. J. Dairy Sci. 61, 44–48.

    Article  CAS  Google Scholar 

  • Pakkanen, R. and Aalto, J. (1997). Growth factors and antimicrobial factors of bovine colostrum. Int. Dairy J. 7, 285–297.

    Article  CAS  Google Scholar 

  • Parreño, V., Béjar, C., Vagnozzi, A., Barrandeguy, M., Costantini, V., Craig, M.I., Yuan, L., Hodgins, D., Saif, L. and Ferñandez, F. (2004). Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine rotavirus. Vet. Immunol. Immunopathol. 100, 7–24.

    Article  CAS  Google Scholar 

  • Parreño, V., Marcoppido, G., Vega, C., Garaicoechea, L., Rodriguez, D., Saif, L. and Ferñandez, F. (2010). Milk supplemented with immune colostrum: protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus. Vet. Immunol. Immunopathol. 136, 12–27.

    Article  CAS  Google Scholar 

  • Pentsuk, N. and van der Laan, J.W. (2009). An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. Birth Defects Res. B Dev. Reprod. Toxicol. 85(Part B), 328–344.

    Google Scholar 

  • Playford, R.J., Macdonald, C.E. and Johnson, W.S. (2000). Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am. J. Clin. Nutr. 72, 5–14.

    CAS  Google Scholar 

  • Prentice, A. (1987). Breast feeding increases concentrations of IgA in infants’ urine. Arch. Dis. Child. 62, 792–795.

    Article  CAS  Google Scholar 

  • Pringnitz, D.J., Butler, J.E. and Guidry, A.J. (1985a). In vivo proteolytic activity of the mammary gland. Contribution to the origin of secretory component, β2-microglobulin and bovine-associated mucoprotein (BAMP) in cow’s milk. Vet. Immunol. Immunopathol. 9, 143–160.

    Article  CAS  Google Scholar 

  • Pringnitz, D.J., Butler, J.E. and Guidry, A.J. (1985b). Quantitation of bovine β2-mircoglobulin: occurrence in body fluids, on fat globules and origin in milk. Mol. Immunol. 22, 779–786.

    Article  CAS  Google Scholar 

  • Pritchett, L.C., Gay, C.C., Besser, T.E. and Hancock, D.D. (1991). Management and production factors influencing immunoglobulin G1 concentration in colostrum from Holstein cows. J. Dairy Sci. 74, 2336–2341.

    Article  CAS  Google Scholar 

  • Quigley, J.D., III, Martin, K.R., Dowlen, H.H., Wallis, L.B. and Lamar, K. (1994). Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. J. Dairy Sci. 77, 264–269.

    Article  Google Scholar 

  • Radaev, S. and Sun, P. (2001). Recognition of immunoglobulins by Fcγ receptors. Mol. Immunol. 38, 1073–1083.

    Article  Google Scholar 

  • Raghavan, M. and Bjorkman, P.J. (1996). Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell Dev. Biol. 12, 181–220.

    Article  CAS  Google Scholar 

  • Rainard, P., Fromageau, A., Cunha, P. and Gilbert, F.B. (2008). Staphylococcus aureus lipoteichoic acid triggers inflammation in the lactating bovine mammary gland. Vet. Res. 39, 52–64.

    Article  CAS  Google Scholar 

  • Rejnek, J., Travnicek, J., Kostka, J., Sterzl, J. and Lanc, A. (1968). Study of the effect of antibodies in the intestinal tract of germ-free baby pigs. Folia Microbiol. 13, 36–42.

    Article  Google Scholar 

  • Renegar, K.B. and Small, P.A., Jr. (1999). Passive immunization: systemic and mucosal, in, Mucosal Immunology, 2nd edn., P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock and J.R. McGhee, eds., Academic, New York. pp. 729–738.

    Google Scholar 

  • Rincheval-Arnold, A., Belair, J. and Djiane, J. (2002). Developmental expression of pIgR gene in sheep mammary gland and hormonal regulation. J. Dairy Res. 69, 13–26.

    CAS  Google Scholar 

  • Robison, J.D., Stott, G.H. and DeNise, S.K. (1988). Effects of passive immunity on growth and survival in the dairy heifer. J. Dairy Sci. 71, 1283–1287.

    Article  CAS  Google Scholar 

  • Rodewald, R. and Kraehenbuhl, J.P. (1984). Receptor-mediated transport of IgG. J. Cell Biol. 99, 159 S–164 S.

    Article  CAS  Google Scholar 

  • Rojas, R. and Apodaca, G. (2002). Immunoglobulin transport across polarized epithelia cells. Nat. Rev. Mol. Cell Biol. 3, 1–12.

    Article  CAS  Google Scholar 

  • Roos, N., Mahe, S., Benamouzig, R., Sick, H., Rautureau, J. and Tome, D. (1995). 15  N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J. Nutr. 125, 1238–1244.

    CAS  Google Scholar 

  • Rosato, R., Jammes, H., Belair, L., Puissant, C., Kraehenbuhl, J.-P. and Djiane, J. (1995). Polymeric-Ig receptor gene expression in rabbit mammary gland during pregnancy and lactation: evolution and hormonal regulation. Mol. Cell. Endocrinol. 110, 81–87.

    Article  CAS  Google Scholar 

  • Rouse, E.T. and Ingram, D.G. (1970). The total protein and immunoglobulin profile of equine colostrum and milk. Immunology 19, 901–907.

    CAS  Google Scholar 

  • Rousseaux, J. and Bazin, H. (1979). Rat immunoglobulins. Vet. Immunol. Immunopathol. 1, 61–78.

    Article  CAS  Google Scholar 

  • Roux, K.H. (1999). Immunoglobulin structure and function as revealed by electron microscopy. Int. Arch. Allergy Immunol. 120, 85–99.

    Article  CAS  Google Scholar 

  • Ruiz-Palacios, G.M., Calva, J.J., Pickering, L.K., Lopez-Vidal, Y., Volkow, P., Pezzarossi, H. and West, M.S. (1990). Protection of breast-fed infants against Campylobacter diarrhea by antibodies in human milk. J. Pediatr. 116, 707–713.

    Article  CAS  Google Scholar 

  • Russell, M.W. (2007). Biological functions of IgA, in, Mucosal Immune Defense: Immunoglobulin A,C.S. Kaetzel, ed., Springer, New York. pp. 144–172.

    Google Scholar 

  • Saif, L.J., Smith, K.L., Landmeier, B.J., Bohl, E.H., Theil, K.W. and Todhunter, D.A. (1984). Immune response of pregnant cows to bovine rotavirus immunization. Am. J. Vet. Res. 45, 49–58.

    CAS  Google Scholar 

  • Saiga, H., Shimada, Y. and Takeda, K. (2011). Innate immune effectors in mycobacterial infection. Clin. Dev. Immunol. 2011, 347594.

    Article  CAS  Google Scholar 

  • Salmon, H. (1995). Immunité lactogene et protection vaccinale dans l’espece porcine. Vet. Res. 26, 232–237.

    CAS  Google Scholar 

  • Sangild, P.T., Trahair, J.F., Loftager, M.K. and Fowden, A.L. (1999). Intestinal macromolecule absorption in the fetal pig after infusion of colostrum in utero. Pediatr. Res. 45, 595–602.

    Article  CAS  Google Scholar 

  • Sasaki, M., Larson, B.L. and Nelson, D.R. (1977). Kinetic analysis of the binding of immunoglobulins IgG1 and IgG2 to bovine mammary cells. Biochim. Biophys. Acta, 497, 160–170.

    Article  CAS  Google Scholar 

  • Schaller, J.P., Saif, L.J., Cordle, C.T., Candler, E., Jr., Winship, T.R. and Smith, K.L. (1992). Prevention of human rotavirus-induced diarrhea in gnotobiotic piglets using bovine antibody. J. Infect. Dis. 165, 623–630.

    Article  CAS  Google Scholar 

  • Schlissel, M.S. (2003). Regulating antigen-receptor gene assembly. Nat. Rev. Immunol. 3, 890–899.

    Article  CAS  Google Scholar 

  • Selim, S.A., Smith, B.P., Cullor, J.S., Blanchard, P., Farver, T.B., Hoffman, R., Dilling, G., Roden, L. and Wilgenburg, B. (1995). Serum immunoglobulins in calves: their effects and two easy, reliable means of measurement. Vet. Med. 90, 387–404.

    Google Scholar 

  • Shimizu, M., Nagashima, H. and Hasimoto, K. (1993). Comparative studies in molecular stability of immunoglobulin G from different species. Comp. Biochem. Physiol. B, 106, 255–261.

    Article  CAS  Google Scholar 

  • Siccardi, D., Turner, J.R. and Mrsny, R.J. (2005). Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease. Adv. Drug Deliv. Rev. 57, 219–235.

    Article  CAS  Google Scholar 

  • Siggers, R.H., Siggers, J., Thymann, T., Boye, M. and Sangild, P.T. (2011). Nutritional modulation of the gut microbiota and immune system in preterm neonates susceptible to necrotizing enterocolitis. J. Nutr. Biochem. 22, 511–521.

    Article  CAS  Google Scholar 

  • Simister, N.E. (2003). Placental transport of immunoglobulin G. Vaccine 21, 3365–3369.

    Article  CAS  Google Scholar 

  • Simister, N.E. and Mostov, K.E. (1989). An Fc receptor structurally related to MHC class I antigens. Nature, 337, 184–187.

    Article  CAS  Google Scholar 

  • Simister, N.E. and Rees, A.R. (1985). Isolation and characterization of an Fc receptor from neonatal rat small intestine. Eur. J. Immunol. 15, 733–738.

    Article  CAS  Google Scholar 

  • Simister, N.E. and Story, C.M. (1997). Human placental Fc receptors and the transmission of antibodies from mother to fetus. J. Reprod. Immunol. 37, 1–23.

    Article  CAS  Google Scholar 

  • Smith, K.L., Muir, L.A., Ferguson, L.C. and Conrad, H.R. (1971). Selective transport of IgG1 into the mammary gland: role of estrogen and progesterone. J. Dairy Sci. 54, 1886–1894.

    Article  CAS  Google Scholar 

  • Sordillo, L.M. and Nickerson, S.C. (1988). Quantification and immunoglobulin classification of plasma cells in nonlactating bovine mammary tissue. J. Dairy Sci. 71, 84–91.

    Article  CAS  Google Scholar 

  • Sordillo, L.M., Shafer-Weaver, K. and DeRosa, D. (1997). Immunobiology of the mammary gland. J. Dairy Sci. 80, 1851–1865.

    Article  CAS  Google Scholar 

  • Spenser, J., Boursier, L. and Edgeworth, J.D. (2007). IgA plasma cell development, in, Mucosal Immune Defense: Immunoglobulin A, C.S. Kaetzel ed., Springer, New York. pp. 25–42.

    Google Scholar 

  • Staley, T.E. and Bush, L.J. (1985). Receptor mechanisms of the neonatal intestine and their relationship to immunoglobulin absorption and disease. J. Dairy Sci. 68, 184–205.

    Article  CAS  Google Scholar 

  • Stechschulte, D.J. and Austen, K.F. (1970). Immunoglobulins of rat colostrum. J. Immunol. 104, 1052–1062.

    CAS  Google Scholar 

  • Stelwagen, K., Carpenter, E., Haugh, B., Hodgkinson, A. and Wheeler, T.T. (2009). Immune components of bovine colostrum and milk. J. Anim. Sci. 87, 3–9.

    Article  CAS  Google Scholar 

  • Struff, W.G. and Sprotte, G. (2007). Bovine colostrum as a biologic in clinical medicine; a review—Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment. Int. J. Clin. Pharmacol. Ther. 45, 193–202.

    CAS  Google Scholar 

  • Struff, W.G. and Sprotte, G. (2008). Bovine colostrum as a biologic in clinical medicine; a review—Part II: clinical studies. Int. J. Clin. Pharmacol. Ther. 46, 211–225.

    CAS  Google Scholar 

  • Sun, J.C., Lopez-Verges, S., Kim, C.C., DeRisi, J.L. and Lanier, L.L. (2011). NK cells and immune “memory”. J. Immunol. 186, 1891–1897.

    Article  CAS  Google Scholar 

  • Targowski, S.P. (1983). Role of immune factors in protection of mammary gland. J. Dairy Sci. 66, 1781–1789.

    Article  CAS  Google Scholar 

  • Telemo, E. and Hanson, L.A. (1996). Antibodies in milk. J. Mammary Gland Biol. Neoplasia. 1, 243–249.

    Article  CAS  Google Scholar 

  • Telleman, P. and Junghans, R.P. (2000). The role of the Brambell receptor (FcRB) in liver: protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology 100, 245–251.

    Article  CAS  Google Scholar 

  • Theil, P.K., Cordero, G., Henckel, P., Puggaard, L., Oksbjerg, N. and Sørensen, M.T. (2011). Effects of gestation and transition diets, piglet birth weight and fasting time on depletion of glycogen pools in liver and 3 muscles of newborn piglets. J. Anim. Sci. 93, 1478–1490.

    Google Scholar 

  • Tizard, I. (2001). The protective properties of milk and colostrum in non-human species, in, Advances in Nutritional Research. Immunological Properties of Milk, Vol. 10, B. Woodward and H.H. Draper, eds., Kluwer, New York, pp. 139–166.

    Google Scholar 

  • Uruakpa, F.O., Ismond, M.A.H. and Akobundu, E.N.T. (2002). Colostrum and its benefits: a review. Nutr. Rev. 22, 755–767.

    CAS  Google Scholar 

  • Vaerman, J.-P. and Heremans, J.F. (1969). The immunoglobulins of the dog—II. The immunoglobulins of canine secretions. Immunochemistry 6, 779–786.

    CAS  Google Scholar 

  • Vaerman, J.-P., Querinjean, P. and Heremans, J.F. (1971). Studies on the IgA system of the horse. J. Immunol. 21, 443–454.

    CAS  Google Scholar 

  • van de Perre, P. (2003). Transfer of antibody via mother’s milk. Vaccine 21, 3374–3376.

    Article  CAS  Google Scholar 

  • Velin, D., Acha Orbea, H. and Kraehenbuhl, J.P. (1996). The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus. J. Virol. 70, 7250–7254.

    CAS  Google Scholar 

  • Weiner, C., Pan, Q., Hurtig, M., Borén, T., Bostwick, E. and Hammarstom, L. (1999). Passive immunity against human pathogens using bovine antibodies. Clin. Exp. Immunol. 116, 193–205.

    Article  CAS  Google Scholar 

  • Wells, D.J., Dargatz, D.A. and Ott, S.L. (1996). Factors associated with mortality to 21 days of life in dairy heifers in the United States. Prev. Vet. Med. 29, 9–19.

    Article  Google Scholar 

  • Wheeler, T.T., Hodgkinson, A.J., Prosser, C.G. and Davis, S.R. (2007). Immune components of colostrum and milk—a historical perspective. J. Mammary Gland Biol. Neoplasia 12, 237–247.

    Article  Google Scholar 

  • Whitney, R. McL. (1988). Proteins in milk, in, Fundamentals of Dairy Chemistry, 3rd edn., N.P. Wong, R. Jenness, M. Keeney and E.M. Marth, eds., AVI, Westport. pp. 81–169.

    Google Scholar 

  • Wilson, M.R., Brown, P. and Svendsen, J. (1972). Immunity to Escherichia coli in pigs: antibody secretion by the mammary gland after intramammary or intramuscular vaccination with E. coli vaccine. Can. J. Comp. Med. 36, 44–48.

    CAS  Google Scholar 

  • Winger, K.L., Gay, C.C. and Besser, T.E. (1995). Immunoglobulin G1 transfer into induced mammary secretions: the effect of dexamethasone. J. Dairy Sci. 78, 1306–1309.

    Article  CAS  Google Scholar 

  • Xanthou, M., Bines, J. and Walker, W.A. (1995). Human milk and intestinal host defense in newborns: an update. Adv. Pediatr. 42, 171–208.

    CAS  Google Scholar 

  • Xu, R.J. (1996). Development of the newborn GI tract and its relation to colostrum/milk intake: a review. Reprod. Fertil. Dev. 8, 35–48.

    Article  CAS  Google Scholar 

  • Yoshida, M., Claypool, S.M., Wagner, J.S., Mizoguchi, E., Mizoguchi, A., Roopenian, D.C., Lencer, W.I. and Blumberg, R.S. (2004). Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769–783.

    Article  CAS  Google Scholar 

  • Yurchak, A.M., Butler, J.E. and Tomasi, T.B., Jr. (1971). Fluorescent localization of immunoglobulins in the tissues of the cow. J. Dairy Sci. 54, 1324–1325.

    CAS  Google Scholar 

  • Yvon, M., Levieux, D., Valluy, M.-C., Pelissier, J.P. and Mirand, P.P. (1993). Colostrum protein digestion in newborn lambs. J. Nutr. 123, 586–596.

    CAS  Google Scholar 

  • Zeitlin, L., Cone, R.A., Moench, T.R. and Whaley, K.J. (2000). Preventing infectious disease with passive immunization. Microbes Infect. 1, 701–708.

    Article  Google Scholar 

  • Zhang, R., Zhao, Z., Zhao, Y., Kacskovics, I., van der Eijk, M. and de Groot, N. (2009). Association of FcRn heavy chain encoding gene (FCGRT) polymorphisms with IgG content in bovine colostrum. Anim. Biotechnol. 20, 242–246.

    Article  CAS  Google Scholar 

  • Zinkernagel, R. (2001). Maternal antibodies, childhood infections, and autoimmune diseases. N. Engl. J. Med. 345, 1331–1335.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    W. L. Hurley

  2. Department of Animal Health and Bioscience, Aarhus University, DK-8830, Tjele, Denmark

    P. K. Theil

Authors
  1. W. L. Hurley
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  2. P. K. Theil
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Correspondence to W. L. Hurley .

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Editors and Affiliations

  1. School of Food and Nutritional Sciences, University College Cork, Cork, College Ro, Ireland

    Paul L. H. McSweeney

  2. Fac. Food Technology & Nutrition, Dept. Food Science, University College Cork, Cork, Ireland

    Patrick F. Fox

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Hurley, W.L., Theil, P.K. (2013). Immunoglobulins in Mammary Secretions. In: McSweeney, P., Fox, P. (eds) Advanced Dairy Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4714-6_9

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