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endoCANNABINOIDS pp 221–233Cite as

Peroxisome Proliferator-Activated Receptors and Inflammation

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Part of the book series: The Receptors ((REC,volume 24))

Abstract

The peroxisome proliferator-activated receptors belong to the superfamily of nuclear receptors which produce their effects, in part, by regulation of gene transcription. There are three peroxisome proliferator-activated receptor (PPAR) isoforms; α, δ (also known as β), and γ, which are activated by a numerous ligands including endocannabinoids. Activation of these receptors has been shown to modulate inflammation, in a number of different animal models. This chapter discusses the evidence that PPAR activation modulates inflammation, inflammatory processes, and immune cell infiltration, as well as reports of adverse effects of PPAR activation, which may have an impact on the therapeutic potential of PPAR agonists as anti-inflammatory agents.

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Abbreviations

IL-1β:

Interleukin 1 beta

PEA:

Palmitoylethanolamide

PPARα:

Peroxisome proliferator-activated receptors alpha

PPARβ/δ:

Peroxisome proliferator-activated receptors beta

PPARγ:

Peroxisome proliferator-activated receptors gamma

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Author information

Authors and Affiliations

  1. Arthritis Research UK Pain Centre, School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, UK

    James Burston

  2. School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, UK

    David Kendall

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  1. James Burston
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  2. David Kendall
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Correspondence to James Burston .

Editor information

Editors and Affiliations

  1. , Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140, Pennsylvania, USA

    Mary E. Abood

  2. National Institutes of Health, Division of Basic Neuroscience and Behav, National Institute on Drug Abuse, 6001 Executive Blvd, Bethesda, 20892, Maryland, USA

    Roger G Sorensen

  3. , Pharmacology and Psychiatry and Behavior, University of Washington, Box 357280, Seattle, 98195, Washington, USA

    Nephi Stella

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Burston, J., Kendall, D. (2013). Peroxisome Proliferator-Activated Receptors and Inflammation. In: Abood, M., Sorensen, R., Stella, N. (eds) endoCANNABINOIDS. The Receptors, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4669-9_10

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