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The Role of Notch Signaling in Multiple Myeloma

  • Dehui Xu
  • Jinsong Hu
  • Elke De Bruyne
  • Eline Menu
  • Karin Vanderkerken
  • Els Van Valckenborgh
Chapter

Abstract

The bone marrow (BM) microenvironment plays a critical role in the multiple myeloma (MM) cell growth and survival. As a highly conserved cell signaling system, the Notch pathway is considered to regulate cell-fate determination, stem cell self-renewal, proliferation, and apoptosis. Notch receptors and ligands are expressed both in MM cells and the BM microenvironment. In this review, we mainly discuss the canonical Notch signaling pathway including background and components of the signaling, its activation, the downstream targets, its regulation, and cross talk with other pathways. We further focus on the role of Notch signaling in multiple myeloma cell growth, angiogenesis, differentiation, drug resistance, bone disease, metastasis, and stem cell biology. A better understanding of Notch signaling in myeloma may provide new strategies to improve current treatment and overall survival.

Keywords

Notch pathway Multiple myeloma Proliferation Angiogenesis Drug resistance Bone disease Differentiation Stem cell Bone marrow microenvironment 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Dehui Xu
    • 1
    • 2
  • Jinsong Hu
    • 1
    • 2
  • Elke De Bruyne
    • 1
  • Eline Menu
    • 1
  • Karin Vanderkerken
    • 1
  • Els Van Valckenborgh
    • 1
  1. 1.Department of Hematology and Immunology-Myeloma Center BrusselsVrije Universiteit Brussel (VUB)BrusselsBelgium
  2. 2.Department of Molecular Biology and GeneticsMedical School of Xi’an Jiaotong UniversityXi’anChina

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