Natural Product Scaffolds in Cancer Therapy

Part of the Cancer Drug Discovery and Development book series (CDD&D)


Natural products are a unique pool of structurally amazing and so far unprecedented novel molecular scaffolds. The sources for these compounds are as diverse as their respective structures and this diversity is reflected by the variety of their mechanisms of action. Even though these compounds selected by evolution were not designed to fight cancer in the first place, they are indispensable in modern cancer therapy. This review gives insight into sources, structural features, and structure activity relationships of a selection of natural products frequently used in cancer therapy. This analysis will be carried out on taxol, eribulin, geldanamycin, camptothecin, epothilone, podophyllotoxin, and the anthracycline scaffolds.


Total Synthesis Coniferyl Alcohol Bioactive Conformation Ring Closing Metathesis Side Chain Analog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.AnalytiCon Discovery GmbHPotsdamGermany

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