Natural Product Scaffolds in Cancer Therapy

Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Natural products are a unique pool of structurally amazing and so far unprecedented novel molecular scaffolds. The sources for these compounds are as diverse as their respective structures and this diversity is reflected by the variety of their mechanisms of action. Even though these compounds selected by evolution were not designed to fight cancer in the first place, they are indispensable in modern cancer therapy. This review gives insight into sources, structural features, and structure activity relationships of a selection of natural products frequently used in cancer therapy. This analysis will be carried out on taxol, eribulin, geldanamycin, camptothecin, epothilone, podophyllotoxin, and the anthracycline scaffolds.

Keywords

Imatinib Trastuzumab Epoxide Quinoline Epirubicin 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.AnalytiCon Discovery GmbHPotsdamGermany

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