Study of Drugs Affecting Cholesterol-Induced Atherosclerosis in Rabbits

  • Y. S. Kwak
  • K. T. Lee
  • D. N. Kim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


Studies in man and animal models reveal that the major events involved in early atherogenesis include lipid deposition and degeneration and proliferation of smooth muscle cells or mesenchymal cells in the intima of aortae (1–4). An atherogenic insult such as hypercholesterolemia may have a direct effect on the endothelial and/or smooth muscle cells of arteries, or an indirect effect on these cells mediated through plasma or tissue factors including platelets, lipoprotein and vasoactive amines including histamine, serotonin and angiotensin (5).


Atherosclerotic Lesion Cholesteryl Ester Acetylsalicylic Acid Surface Active Agent Cholesteryl Ester Hydrolase 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Y. S. Kwak
    • 1
  • K. T. Lee
    • 2
  • D. N. Kim
    • 2
  1. 1.Clinical Chemistry Section, Laboratory ServiceVA HospitalAlbanyUSA
  2. 2.Department of PathologyAlbany Medical CollegeAlbanyUSA

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