Seasonal Variations in Severity of Experimental Atherosclerosis in Rabbits

  • David Kritchevsky
  • Shirley A. Tepper
  • Jon A. Story
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


For fifteen years, we have been conducting numerous experiments on the induction of atherosclerosis in male Dutch belted rabbits, testing a variety of dietary fats and several hypolipidemic drugs. In all of these experiments, the standard atherogenic regimen that provided the basis for comparison of treatments was 2% cholesterol and 6% corn oil added to laboratory ration. Although each experiment contained its own control, we noted that the atheromata in the control rabbits varied from experiment to experiment. In an effort to ascertain a possible seasonal variation in atherosclerosis we have collated by month of autopsy data from 74 experimental identical 2-month feeding periods.


Seasonal Variation Serum Cholesterol Level Control Rabbit Autopsy Data Stock Diet 
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  1. 1.
    G.L. Duff and G.C. McMillan. The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. J. Exp. Med. 89:611–630 (1949).PubMedCrossRefGoogle Scholar
  2. 2.
    P. Trinder. Determination of cholesterol in serum. Analyst 77:321–326 (1952).CrossRefGoogle Scholar
  3. 3.
    G.V. Mann. A method for measurement of cholesterol in blood serum. Clin. Chem. 7:275–284 (1961).PubMedGoogle Scholar
  4. 4.
    S. Pearson, S. Stern and T.H. McGavack. A rapid, accurate method for the determination of total cholesterol in serum. Analyt. Chem. 25:813–814 (1953).CrossRefGoogle Scholar
  5. 5.
    C.B. Thomas, H.W.D. Holljes and F.F. Eisenberg. Observations on seasonal variations in total serum cholesterol levels among healthy young prisoners. Ann. Int. Med. 54:413–430 (1961).PubMedCrossRefGoogle Scholar
  6. 6.
    J. Paloheimo. Seasonal variations of serum lipids in healthy young men. Ann. Med. Exp. Biol. Fenn. 39:Suppl. 8 (1961).Google Scholar
  7. 7.
    J. Kocemba, L. Szopinska-Ciba, T. Ciba and L. Tochowicz. Seasonal variations of serum cholesterol levels in healthy and in atherosclerotic subjects. Bull. Polish Med. Sci. History 6:10–13 (1963).Google Scholar
  8. 8.
    J.P. Strong, P.B. Radelat, M.H. Guidry and C.A. McMahon. Variability of serum cholesterol levels in baboons. Circ. Res. 14:367–372 (1964).PubMedCrossRefGoogle Scholar
  9. 9.
    D. Kritchevsky, E.S. Kritchevsky, P.P. Nair, J.A. Jastremsky and I.L. Shapiro. Effect of free fatty acids on cholesterol metabolism in the baboon. Nutr. Dieta 9:283–299 (1967).Google Scholar
  10. 10.
    D. Kritchevsky, L.M. Davidson, I.L. Shapiro, H.K. Kim, M. Kitagawa, S. Malhotra, P.P. Nair, T.B. Clarkson, I. Bersohn and P.A.D. Winter. Lipid metabolism and experimental atherosclerosis in baboons: influence of cholesterol-free, semisynthetic diets. Am. J. Clin. Nutr. 27:29–50 (1974).PubMedGoogle Scholar
  11. 11.
    D. Kritchevsky and R.F.J. McCandless. Weekly variations in serum cholesterol levels of monkeys. Proc. Soc. Exp. Biol. Med. 95:152–154 (1957).PubMedGoogle Scholar
  12. 12.
    G.E. Cox, C.B. Taylor, L.G. Cox and M.A. Counts. Atherosclerosis in rhesus monkeys. I. Hypercholesteremia induced by dietary fat and cholesterol. Arch. Pathol. 66:32–52 (1958).Google Scholar
  13. 13.
    J.M. Thorp. Effects of seasonal variation on lipid metabolism in animals and man. In “The Control of Lipid Metabolism”, ed. J.K. Grant, Academic Press, N.Y., 1963, pp. 163–168.Google Scholar
  14. 14.
    D. Kritchevsky. Experimental atherosclerosis in rabbits fed cholesterol-free diets. J. Atheroscler. Res. 4:103–105 (1964).PubMedCrossRefGoogle Scholar
  15. 15.
    D. Kritchevsky and H.V. Kothari. Aortic cholesterol esterase in species resistant or susceptible to atherosclerosis. Steroids and Lipids Res. 5:23–27 (1974).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • David Kritchevsky
    • 1
  • Shirley A. Tepper
    • 1
  • Jon A. Story
    • 1
  1. 1.Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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