Phylogenetic Variability of Serum Lipids and Lipoproteins in Nonhuman Primates Fed Diets with Different Contents of Dietary Cholesterol

  • S. R. Srinivasan
  • C. C. Smith
  • B. Radhakrishnamurthy
  • R. H. Wolf
  • G. S. Berenson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


The response of serum lipids and lipoproteins to different levels of dietary cholesterol (0.05% to 1.5% w/w) was measured in six nonhuman primate species. Relative response of serum cholesterol in different species, measured in terms of response index, varied with dietary cholesterol concentration. The overall response for the different diets allowed ranking of the species as follows: Squirrel > green > spider ≃ rhesus ≃ patas > chimpanzee. The serum cholesterol response was reflected not only in an increase in β + pre-β-lipoprotein cholesterol but also in α-lipoprotein cholesterol, with significant differences among species in the amount of cholesterol transported in the lipoprotein classes.


Rhesus Monkey Serum Lipid Squirrel Monkey Dietary Cholesterol Spider Monkey 
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  1. 1.
    Scott, R. F., E. S. Morrison, J. Jarmolych, S. C. Nam, M. Kroms, and F. Coulston. 1967. Experimental atherosclerosis in rhesus monkeys. I. Gross light microscopy features and lipid in serum and aorta. Exp. Mol. Pathol. 7:11–33.PubMedCrossRefGoogle Scholar
  2. 2.
    Taylor, C. B., G. E. Cox, P. Manalo-Extrella, and J. Southworth. 1962. Atherosclerosis in rhesus monkeys. II, Arterial lesions associated with hypercholesteremia induced by dietary fat and cholesterol. Arch. Path. 74:16–34.PubMedGoogle Scholar
  3. 3.
    Wissler, R. W., G. S. Getz, D. Vesselinovitch, L. E. Frazier, and R. H. Hughes. 1966. Acute severe experimental atherosclerosis in rhesus monkeys. Fed, Proc. 25:597.Google Scholar
  4. 4.
    Strong, J. P. and H. C. McGill. 1967. Diet and experimental atherosclerosis in baboons. Am, J. Pathol. 50:669–690.Google Scholar
  5. 5.
    Malinow, M. R., C. A. Maruffo, and A. M. Perley. 1966. Experimental atherosclerosis in squirrel monkeys (Saimiri sciurea). J. Pathol. Bacteriol. 92:491–510.PubMedCrossRefGoogle Scholar
  6. 6.
    Middleton, C.C. T. B. Clarkson, H. B. Lofland, and R. W. Prichard. 1967. Diet and atherosclerosis of squirrel monkeys. Arch. Pathol. 83:145–153.PubMedGoogle Scholar
  7. 7.
    Portman, O. W. and S. B. Andrus. 1965. Comparative evaluation of three species of New World monkeys for studies of dietary factors, tissue lipids, and atherogenesis. J. Nutr. 87:429–438.PubMedGoogle Scholar
  8. 8.
    Clarkson, T. B., H. B. Lofland, B. C. Bullock, N. D. M. Lehner, R. W. St. Clair, and R. W. Prichard. 1969. Atherosclerosis in some species of New World monkeys. Ann. N. Y. Acad. Sci. 162:102–109.CrossRefGoogle Scholar
  9. 9.
    Wissler, R. W., L. E. Frazier, R. H. Hughes, and R. A. Rasmussen. 1962. Atherogenesis in the cebus monkey. Arch. Pathol. 74:312–322.PubMedGoogle Scholar
  10. 10.
    Pucak, G. J., N. D. M. Lehner, T. B. Clarkson, B. C. Bullock, and H. B. Lofland. 1973. Spider monkeys (Ateles Sp.) as animal models for atherosclerosis research. Exp. Mol. Pathol. 18:32–49.PubMedCrossRefGoogle Scholar
  11. 11.
    Srinivasan, S. R., A. Lopez-S, B. Radhakrishnamurthy, and G. S. Berenson. 1970. Complexing of serum pre-β-and β-lipoproteins and acid mucopolysaccharides. Atherosclerosis 12:321–334.PubMedCrossRefGoogle Scholar
  12. 12.
    Berenson, G. S., S. R. Srinivasan, A. Lopez-S. B. Radhakrishnamurthy, P. S. Pargaonkar, and R. H. Deupree. 1972. Clinical application of an indirect method for quantitating serum lipoproteins. Clin. Chim. Acta 36:175–183.PubMedCrossRefGoogle Scholar
  13. 13.
    Srinivasan, S. R., A. Lopez-S, B. Radhakrishnamurthy, and G. S. Berenson. 1970. A simplified technique for semi-quantitative, clinical estimation of serum β-and pre-β-lipoproteins. Angiologica 7:344–350.PubMedGoogle Scholar
  14. 14.
    Srinivasan, S. R., R. R. Frerichs, and G. S. Berenson. 1975. Serum lipids and lipoprotein profile in school children from a rural community. Clin. Chim. Acta. 60:293–302.PubMedCrossRefGoogle Scholar
  15. 15.
    Bowyer, D. E., J. S. Cridland, J. D. Pearson, J. P. King, and M. A. Reidy. 1974. A “Plasma cholesterol index” for the more precise prediction of atherosclerotic lesion formation in experimental animals. In Atherosclerosis III. Ed. by G. Schettler and A. Weizel, Springer-Verlag, New York, pp. 847–848.Google Scholar
  16. 16.
    Eggen, D. A., J. P. Strong, and W. P. Newman III. 1969. Experimental atherosclerosis in primates: a comparison of selected species. Ann. N. Y. Acad. Sci. 162:110–119.PubMedCrossRefGoogle Scholar
  17. 17.
    Corey, J. E., K. C. Hayes, B. Dorr, and D. M. Hegsted. 1974. Comparative lipid response of four primate species to dietary changes in fat and carbohydrate. Atherosclerosis 19:119–134.PubMedCrossRefGoogle Scholar
  18. 18.
    Manning, P. J., T. B. Clarkson, and H. B. Lofland. 1971. Cholesterol absorption turnover and excretion rates in hypercholesterolemic rhesus monkeys. Exp. Molec. Pathol. 14:75–89.CrossRefGoogle Scholar
  19. 19.
    Dietschy, J. M. and J. D. Wilson. 1970. Regulation of cholesterol metabolism. Parts I–III. New Engl. J. Med. 282:1128–1138, 1179-1183, 1241-1249.Google Scholar
  20. 20.
    Kritchevsky, D. 1969. Experimental atherosclerosis in primates and other species. Ann. N. Y. Acad. Sci. 162:80–88.PubMedCrossRefGoogle Scholar
  21. 21.
    Eggen, D. A. 1974. Cholesterol metabolism in rhesus monkey, squirrel monkey, and baboon. J. Lipid Res. 15:139–145.PubMedGoogle Scholar
  22. 22.
    Ho, K-J. and C. B. Taylor. 1970. Control mechanisms of cholesterol biosynthesis. Arch. Pathol. 90:83–92.PubMedGoogle Scholar
  23. 23.
    Gresham, G. A., A. N. Howard, J. McQueen, and D. E. Bowyer. 1965. Atherosclerosis in primates. Brit. J. Exp. Pathol. 46:94–103.Google Scholar
  24. 24.
    Armstrong, M. L., M. B. Megan, and E. D. Warner, 1974. Intimal thickening in normocholesterolemic rhesus monkeys fed low supplements of dietary cholesterol. Circ. Res. 34:447–454.PubMedCrossRefGoogle Scholar
  25. 25.
    Kritchevsky, D. 1970. Cholesterol metabolism in the baboon, Trans. N. Y. Acad. Sci. 32:821–831.CrossRefGoogle Scholar
  26. 26.
    Srinivasan, S. R., E. R. Dalferes, Jr., H. Ruiz, P. S. Pargaonkar, B. Radhakrishnamurthy, and G. S. Berenson. 1972. Rapid serum lipoprotein changes in spider monkeys on shortterm feeding of high cholesterol—high saturated fat diet. Proc. Soc. Exp. Biol. Med. 141:154–159.PubMedGoogle Scholar
  27. 27.
    Calvert, G. D. and P. J. Scott. 1974. Serum lipoproteins in pigs on high-cholesterol-high-triglyceride diets. Atherosclerosis 19:485–492.PubMedCrossRefGoogle Scholar
  28. 28.
    Morris, M. D. and W. E. Greer. 1972. Hyperalpha-lipoproteinemia in cholesterol-fed rhesus monkeys. Fed Proc. 31:727.Google Scholar
  29. 29.
    Nichols, A. V. 1969. Functions and interrelationships of different classes of plasma lipoproteins. Proc. Nat. Acad. Sci. USA, 64:1128–1337.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • S. R. Srinivasan
    • 1
  • C. C. Smith
    • 1
  • B. Radhakrishnamurthy
    • 1
  • R. H. Wolf
    • 1
  • G. S. Berenson
    • 1
  1. 1.Dept. of MedicineLSU School of Medicine and The Delta Primate Center of Tulane UniversityNew OrleansUSA

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