Mechanism of Inhibition of Cholesterol Uptake by the Arterial Wall

  • R. J. Bing
  • J. S. M. Sarma
  • R. Fischer
  • S. Ikeda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


Our early studies on in vitro perfused aortas and coronary arteries have dealt with lipid synthesis and cholesterol (cholest-5-en-3β-ol) uptake by the arterial wall. In the course of these studies, we noticed that the addition of 7-ketocholesterol (3β-hydroxycholest-5-en-7one) to the perfusion fluid resulted in a significant inhibition of cholesterol uptake by the arterial wall of different species, without interfering with lipid synthesis. Because of this finding, this report will be primarily concerned with this inhibition and its mechanisms. However earlier studies on lipid synthesis and cholesterol uptake by isolated perfused arteries will also be discussed since the technique and the results have a bearing on inhibitory effects of 7-ketocholesterol.


Bile Salt Arterial Wall Lipid Synthesis Familial Hypercholesterolemia Cholesterol Uptake 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • R. J. Bing
    • 1
    • 2
  • J. S. M. Sarma
    • 1
    • 2
  • R. Fischer
    • 1
    • 2
  • S. Ikeda
    • 1
    • 2
  1. 1.Huntington Memorial HospitalPasadenaUSA
  2. 2.University of Southern CaliforniaLos Angeles, PasadenaUSA

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