Mechanism of Inhibition of Cholesterol Uptake by the Arterial Wall
Our early studies on in vitro perfused aortas and coronary arteries have dealt with lipid synthesis and cholesterol (cholest-5-en-3β-ol) uptake by the arterial wall. In the course of these studies, we noticed that the addition of 7-ketocholesterol (3β-hydroxycholest-5-en-7one) to the perfusion fluid resulted in a significant inhibition of cholesterol uptake by the arterial wall of different species, without interfering with lipid synthesis. Because of this finding, this report will be primarily concerned with this inhibition and its mechanisms. However earlier studies on lipid synthesis and cholesterol uptake by isolated perfused arteries will also be discussed since the technique and the results have a bearing on inhibitory effects of 7-ketocholesterol.
KeywordsBile Salt Arterial Wall Lipid Synthesis Familial Hypercholesterolemia Cholesterol Uptake
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