Effects of Cholesterol Derivatives on Sterol Biosynthesis

  • Harry W. Chen
  • Andrew A. Kandutsch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


Atherosclerosis is a condition marked by the formation of plaques in the endothelium of the arterial system which in the earliest stage are composed largely of cholesterol. The etiology of the disease is not known, although it appears that an elevated serum cholesterol level may contribute to the development and the progression of atherosclerosis in animals and in man. The production of atherosclerotic lesions in experimental animals on a cholesterol-supplemented diet suggested a connection between cholesterol and atherosclerosis.


Plasma Cholesterol Level Sterol Biosynthesis Sterol Synthesis Cholesterol Derivative Dietary Sterol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



3-hydroxy-3-methylglutaryl Coenzyme A


mevalonic acid


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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Harry W. Chen
    • 1
  • Andrew A. Kandutsch
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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