A Mechanism for Lipid Accumulation and Central Necrosis in Fibrous Plaques

  • L. Clarke Stout
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


This is a step section study of 3 fibrous plaques from the abdominal aorta of an ostrich. The distribution of gelatinous like lesions in these plaques suggested that the gelatinous lesions were formed by the influx of plasma at the plaque shoulders. Two gelatinous lesions extended like tunnels into the center of one of the plaques. The presence of focal necrosis and large cholesterol crystals in one of these gelatinous tunnels deep within the plaque suggested that gelatinous lesions might represent one mechanism by which fibrous plaques are converted to atheromatous plaques.


Smooth Muscle Cell Lipid Accumulation Central Necrosis Atheromatous Plaque Focal Necrosis 
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  1. 1.
    Stout, C. and F. Bohorquez. 1973. Arteriosclerosis and other vascular diseases in zoo and laboratory animals. In: Research Animals in Medicine, Ed. by Lowell T. Harmison, DHEW Publication No. (NIH) 72-333, U.S. Gov’t Printing Office, Stock No. 1740-0338, Washington, D.C. pp 841–859.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • L. Clarke Stout
    • 1
  1. 1.Dept. of PathologyUniversity of Texas Medical BranchGalvestonUSA

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