Produced by Selective Breeding of Japanese Quail Animal Model for Experimental Atherosclerosis

  • K. P. Chapman
  • W. W. Stafford
  • C. E. Day
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)

Abstract

The Japanese quail (Coturnix coturnix japonica) was bred selectively to produce a strain highly susceptible to experimental atherosclerosis. A population was produced where aortic atherosclerosis is contracted by 99% of the fourth generation males and 83% of the females. Forty-three percent of the males exhibited severe atherosclerosis making this line of Japanese quail a suitable model for discovering and testing anti-atherosclerosis compounds. This feature is augmented by other features such as size, disposition, and abundance which qualify them as suitable experimental subjects. A second line of Japanese quail was bred to be resistant to dietary-induced atherosclerosis. This strain may be a useful research tool for characterizing the etiology of atherosclerosis.

Keywords

Cholesterol Albumin Urea Lactate Bilirubin 

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • K. P. Chapman
    • 1
  • W. W. Stafford
    • 1
  • C. E. Day
    • 1
  1. 1.The Upjohn CompanyKalamazooUSA

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