Advertisement

Diet-Induced Hypercholesterolemia in the Diabetic and Non-Diabetic Chinese Hamster

  • M. G. Soret
  • M. C. Blanks
  • G. C. Gerritsen
  • C. E. Day
  • E. M. Block
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)

Abstract

The association of human diabetes and the development of vascular disease has been established (1–4). Since the spontaneous diabetes in the Chinese hamster (Cricetulus griseus) (5) has been considered a good experimental model of the human disease (6) it was considered of interest to find if this animal was also suited for the study of vascular diseases, whether induced or naturally occurring. The present study was designed to investigate some morphologic and metabolic effects of diet induced hypercholesterolemia in the Chinese hamster.

Keywords

Control Diet Cholesterol Diet Fast Blood Sugar Plasma Cholesterol Level Mild Diabetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ahuja, M.M., V. Gossnian, C.K. Bhan, and V. Kumar. 1972. Vascular disease in north Indian diabetics in relation to diet and blood lipids. In Impact of Insulin on Metabolic Pathways, ed. by P. Shafrier, Academic Press, New York, p. 423.Google Scholar
  2. 2.
    Elkeles, R.J., C. Lowy, A.D.H. Wyllie, J.L. Young, and T.R. Fraser. 1971. Serum insulin, glucose, and lipid levels among mild diabetics in relation to incidence of vascular complications. Lancet 1:880–883.PubMedCrossRefGoogle Scholar
  3. 3.
    Keen, H. 1970. Minimal diabetes and arterial disease: prevalence and the effect of treatment. In Advances in Metabolic Disorders (Suppl. 1), ed. by Camerini-Davalos, R.A. and H.S. Cole, Academic Press, New York, pp. 437–440.Google Scholar
  4. 4.
    Levitas, I.M., and J.J. Kristal. 1972. Stress exercise testing of the young diabetic for the detection of unknown coronary artery disease. In Impact of Insulin on Metabolic Pathways, ed. by P. Shafrier, Academic Press, New York, pp. 491–493.Google Scholar
  5. 5.
    Meier, H. and G.A. Yerganian. 1959. Spontaneous hereditary diabetes mellitus in Chinese hamster (Cricetulus griseus): I. Pathologic findings. Proc. Soc. Exp. Biol. 100:810–815.PubMedGoogle Scholar
  6. 6.
    Gerritsen, G.C. and W.E. Dulin. 1967. Characterization of diabetes in the Chinese hamster. Diabetologia 3:74–84.PubMedCrossRefGoogle Scholar
  7. 7.
    Riley, V. 1960. Adaptation of orbital bleeding technique to rapid serial bleeding. Proc. Soc. Exp. Biol. Med. 104:754–760.Google Scholar
  8. 8.
    Hoffman, W.S. 1937. A rapid photoelectric method for the determination of glucose in blood and urine. J. Biol. Chem. 120:51–55.Google Scholar
  9. 9.
    Block, W.D., K.J. Jarrett, Jr., and J.B. Levine. 1965. Use of a single color reagent to improve the automated determination of serum total cholesterol. In Automation in Analytical Chemistry, ed. by L.T. Skeggs, Jr., Mediad Inc., pp. 345–347.Google Scholar
  10. 10.
    Alexander, C. and C.E. Day. 1973. Distribution of serum lipoproteins of selected vertebrates. Comp. Biochem. Physiol. 46B:295–312.Google Scholar
  11. 11.
    Day, C.E. and W.W. Stafford. 1975. New animal model for atherosclerosis research. In Lipids, Lipoproteins, and Drugs, ed. by D. Kritchevsky, R. Paoletti, and W. Holmes, Plenum Press, New York, pp. 339–347.CrossRefGoogle Scholar
  12. 12.
    Day, C.E., P.E. Schurr, W.E. Heyd, and D. Lednicer. 1976. Biological activity of a hypobetalipoproteinemic agent. In Atherosclerosis Drug Discovery, ed. by C.E. Day, Plenum Press, New York, pp. 231–249.Google Scholar
  13. 13.
    Chobanian, A.V., G.C. Gerritsen, P.I. Brecher, and M. Kessler. 1974. Cholesterol metabolism in the diabetic Chinese hamster. Diabetologia 10:595–600.PubMedCrossRefGoogle Scholar
  14. 14.
    Day, C.E. Unpublished Data.Google Scholar
  15. 15.
    Manning, P.J. and T.B. Clarkson. 1970. Diet-induced atherosclerosis of the cat. Arch. Path. 89:271–278.Google Scholar
  16. 16.
    Wellmann, K.F. and B.W. Volk. 1970. Renal changes in experimental hypercholesterolemia in normal and subdiabetic rabbits. I. Short term studies. Lab. Invest. 22:36–49.PubMedGoogle Scholar
  17. 17.
    Bierring, F. and T. Kobayashi. 1963. Electron microscopy of the normal rabbit aorta. Acta Pathol. Microbiol. Scand. 57: 154–168.PubMedCrossRefGoogle Scholar
  18. 18.
    Pease, D.C. and W.J. Paule. 1960. Electron microscopy of elastic arteries; the thoracic aorta of the rat. J. Ultra. Res. 3:469–483.CrossRefGoogle Scholar
  19. 19.
    Keech, M.K. 1960. Electron microscope study of the normal rat aorta. J. Biophysic. Biochem. Cytol. 7:533–543.CrossRefGoogle Scholar
  20. 20.
    Clarkson, T.B. 1963. Atherosclerosis-spontaneous and induced. In Advances in Lipid Research, ed. by R. Paoletti and D. Kritchevsky, Academic Press, New York, pp. 211–252.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • M. G. Soret
    • 1
  • M. C. Blanks
    • 1
  • G. C. Gerritsen
    • 1
  • C. E. Day
    • 1
  • E. M. Block
    • 1
  1. 1.The Upjohn CompanyKalamazooUSA

Personalised recommendations