Importance of Sex and Estrogens in Amelioration of Lethal Circulatory Stress Reactions: Relationship to Microcirculatory and Reticuloendothelial System Function

  • Burton M. Altura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


Recently, sex hormones have been shown to alter the concentration of elastin and collagen in the vascular walls of chickens (1) and rats (2,3). Administration of estrogen has also been reported to result in a decrease in mucopolysaccharide content (4) as well as to decrease oxygen consumption of the vascular wall (5). It has been postulated by a number of investigators that these changes may be important in the development, and amelioration, of atherosclerotic lesions (6–8). The influence of sex and sex hormones on vascular reactivity has not, however, been systemically investigated. Furthermore, since injury (and inflammation) is thought to act as a potent stimulus for initiation of development of atherosclerotic lesions (8–12), it would be important to determine whether sex, or estrogen administration, can influence a mammal’s reaction to a systemic injury which has as its target the peripheral vascular system.


Bowel Ischemia Circulatory Shock Phagocytic Index Neurohypophyseal Hormone Circulatory Stress 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Burton M. Altura
    • 1
  1. 1.Department of PhysiologyS.U.N.Y. Downstate Medical CenterBrooklynUSA

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