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Importance of Sex and Estrogens in Amelioration of Lethal Circulatory Stress Reactions: Relationship to Microcirculatory and Reticuloendothelial System Function

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Atherosclerosis Drug Discovery

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 67))

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Abstract

Recently, sex hormones have been shown to alter the concentration of elastin and collagen in the vascular walls of chickens (1) and rats (2,3). Administration of estrogen has also been reported to result in a decrease in mucopolysaccharide content (4) as well as to decrease oxygen consumption of the vascular wall (5). It has been postulated by a number of investigators that these changes may be important in the development, and amelioration, of atherosclerotic lesions (6–8). The influence of sex and sex hormones on vascular reactivity has not, however, been systemically investigated. Furthermore, since injury (and inflammation) is thought to act as a potent stimulus for initiation of development of atherosclerotic lesions (8–12), it would be important to determine whether sex, or estrogen administration, can influence a mammal’s reaction to a systemic injury which has as its target the peripheral vascular system.

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Authors and Affiliations

  1. Department of Physiology, S.U.N.Y. Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York, 11203, USA

    Burton M. Altura

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  1. Burton M. Altura
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  1. Atherosclerosis Research, The Upjohn Company, Kalamazoo, Michigan, USA

    Charles E. Day

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Altura, B.M. (1976). Importance of Sex and Estrogens in Amelioration of Lethal Circulatory Stress Reactions: Relationship to Microcirculatory and Reticuloendothelial System Function. In: Day, C.E. (eds) Atherosclerosis Drug Discovery. Advances in Experimental Medicine and Biology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4618-7_17

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  • DOI: https://doi.org/10.1007/978-1-4614-4618-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9309-3

  • Online ISBN: 978-1-4614-4618-7

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