Biological Activity of a Hypobetalipoproteinemic Agent

  • Charles E. Day
  • Paul E. Schurr
  • William E. Heyd
  • Daniel Lednicer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


A new kind of pharmacologic activity called hypobetalipoproteinemia is described. Operationally the activity consists of a marked reduction of heparin precipitating lipoproteins (beta and/or pre-beta electrophoretic mobility) in hypercholesterolemic animals with a simultaneous decrease in the heparin precipitating lipoprotein:cholesterol ratio. As determined by ultracentrifugal fractionation of the lipoproteins from hypercholesterolemic rat serum, this activity consists of both a reduction in heparin precipitating lipoproteins and an increase in high density lipoproteins that are not precipitated by heparin. Changes in composition were also induced in both lipoprotein fractions. The greatest changes were observed for free and esterified cholesterol, which were markedly reduced in the heparin precipitating lipoproteins and concomitantly increased in the high density lipoproteins. The hypobetalipoproteinemic agent exhibiting this activity is 1-[p-(1′-adamantyloxy)phenyl]-piperidine (U-41792). This agent is active in hypercholesterolemic rats, mice, quail, and pigeons.


Cholesterol Ester Cholic Acid Free Cholesterol Japanese Quail Serum Serum 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Charles E. Day
    • 1
  • Paul E. Schurr
    • 1
  • William E. Heyd
    • 1
  • Daniel Lednicer
    • 1
  1. 1.The Upjohn CompanyKalamazooUSA

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