Abstract
That deprivation of oxygen may be a factor in atherogenesis is not a new theory. A review of the hypoxia phenomenon was presented by Heuper (1) in the mid 1940’s. He suggested that the common action of agents which cause vascular injury leading to edema or atherosclerosis is an interference with the oxidative metabolism of the vascular wall.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hueper, W. C. 1944. Arteriosclerosis, the anoximia theory. Arch. Pathol. 39: 162, 245, 350.
Kjeldsen, K., J. Wanstrup and P. Astrup. 1968. Enhancing influence of arterial hypoxia on the development of atheromatosis in cholesterol-fed rabbits. J. Atheroscler. Res. 8: 835–845.
Kipshidze, N. N. 1959. The effect of oxygen deficiency on the development of experimental atherosclerosis of the coronary arteries. Bull. Exp. Biol. Med. 47: 447–453.
Astrup, P., K. Kjeldsen and J. Wanstrup. The effects of exposure to carbon monoxide, hypoxia and hyperoxia on the development of experimental atheromatosis in rabbits. In: Atherosclerosis, Proceedings of the Second International Symposium. Ed. by R. J. Jones, Springer-Verlag, New York, pp. 108-111.
Helin. P., I. Lorenzen, C. Garbarsch and M. E. Matthiessen. 1969. Arteriosclerosis and hypoxia, Part 2 (Biochemical changes in mucopolysaccharides and collagen of rabbit aorta induced by systemic hypoxia). J. Atheroscler. Res. 9:295–304.
Helin, P. and I. Lorenzen. 1969. Arteriosclerosis in rabbit aorta induced by systemic hypoxia. Angiology 20:1–12.
Garbarsch, C., M. E. Matthiessen, P. Helin and I. Lorenzen. 1969. Arteriosclerosis and hypoxia, Part 1 Gross and microscopic changes in rabbit aorta, induced by systemic hypoxia. Histochemical studies. J. Atheroscler. Res. 9:283–294.
Constantinides, P., 1970. The role of endothelial injury in arterial thrombosis and atherogenesis. Adv. Cardiol. 4:67–71.
Wanstrup, J., K. Kjeldsen and P. Astrup. 1969. Acceleration of spontaneous intimal-subintimai changes in rabbit aorta by a prolonged moderate carbon monoxide exposure. Acta Pathol. Micro. Scand. 75:353–362.
Kjeldsen, K., P. Astrup and J. Wanstrup. 1969. Reversal of rabbit atheromatosis by hyperoxia. J. Atheroscler. Res. 10:173–178.
Dixon, K. C. 1961. Deposition of globular lipid in arterial cells in relation to anoxia. Amer. J. Path. 39:65–74.
Woener. C. A. 1959. Vasa vasorum of arteries, their demonstration and distribution. In: The Arterial Wall. Ed. by A. I. Lansing, Williams and Wilkins, Baltimore, pp. 1-14.
Kirk, J. E. and T. J. S. Laursen. 1955. Diffusion coefficients of various solutes for human aortic tissue with special reference to variation in tissue permeability with age. J. Gerontol. 10: 288–302.
Robertson, A. L., Jr. 1968. Oxygen requirements of the human arterial intima in atherogenesis. Progr. Biochem. Pharmacol. 4:305–316.
Kjeldsen, K. 1969. Smoking and Atherosclerosis. Thesis at University of Copenhagen, Munksgaard, Copenhagen.
Chisolm, G. M., III, J. L. Gainer, G. E. Stoner and J. V. Gainer, Jr. 1972. Plasma proteins, oxygen transport and atherosclerosis. Atherosclerosis 15:327–343.
Chisolm, G. M. III and J. L. Gainer. 1973. Altering diffusion rates. In: Oxygen Transport to Tissue—Pharmacology, Mathematical Studies and Neonatology. Ed. by D. F. Bruley and H. I. Bicher, Plenum Press, New York, pp. 729–731.
Chisolm, G. M., III, J. L. Gainer and A. J. Raineri, Jr. 1973. Proteins and atherosclerosis. Experientia 29: 167.
Chisolm, G. M. III., E. N. Terrado and J. L. Gainer. 1971. Physiological transport in relation to ageing. Nature 230: 390–391.
Gainer, J. L. and G. M. Chisolm III. 1974. Oxygen diffusion and atherosclerosis. Atherosclerosis 19:135–138.
Gainer, J. L. and J. R. Jones. 1975. The use of crocetin in experimental atherosclerosis. Experientia 31:548–549.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pool, J.D., Gainer, J.L., Chisolm, G.M. (1976). Oxygen Diffusion and Atherosclerosis. In: Day, C.E. (eds) Atherosclerosis Drug Discovery. Advances in Experimental Medicine and Biology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4618-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4618-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9309-3
Online ISBN: 978-1-4614-4618-7
eBook Packages: Springer Book Archive