Evaluation of the Permeability Parameters (Influx, Efflux and Volume of Distribution) of Arterial Wall for LDL and Other Proteins

  • S. Ghosh
  • J. N. Finkelstein
  • D. B. Moss
  • J. S. Schweppe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 67)


Atherosclerosis is generally considered to be a multifactorial disease; as such, the prevention or cure of the disease may be approached at different levels, control of serum cholesterol or β-lipoprotein being an important one. However, the ultimate manifestation of the disease is in the arterial wall, and any prospective drug will have to be effective in producing the beneficial action at the arterial level. From this point of view it is of great importance to be able to monitor the effect of a drug on the relevant processes at the arterial wall. For the present discussion the arterial permeability to serum proteins, low density lipoprotein (LDL) in particular, will be taken as the relevant process.


Arterial Wall Arterial Tissue Permeability Parameter Arterial Uptake Rabbit Serum Albumin 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • S. Ghosh
    • 1
  • J. N. Finkelstein
    • 1
  • D. B. Moss
    • 1
  • J. S. Schweppe
    • 1
  1. 1.Departments of Biochemistry and MedicineNorthwestern University Medical SchoolChicagoUSA

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