Biochemical Evidence on the Role of Gangliosides in Nerve-Endings

  • I. G. Morgan
  • G. Tettamanti
  • G. Gombos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)


The nervous system, compared to other tissues, is characterized by high ganglioside levels, most particularly of the tri- and tetra-sialogangliosides (WIEGANDT, 1968). This simple fact has led to many suggestions that gangliosides must have a neuro-specific function to match their neurospecific concentration and pattern. The purpose of this article is to examine the evidence that the gangliosides have a role in synaptic function, since it is at the synaptic region that the gangliosides seem to be concentrated.


Sialic Acid Synaptic Vesicle Neuronal Cell Body Sialic Acid Residue FEBS Letter 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • I. G. Morgan
    • 1
  • G. Tettamanti
    • 2
  • G. Gombos
    • 3
  1. 1.Department of Behavioural Biology, Research School of Biological SciencesAustralian National UniversityCanberra CityAustralia
  2. 2.Istituto di Chimica BiologicaUniversità di MilanoMilanoItalia
  3. 3.Centre de Neurochimie du CNRSStrasbourg CédexFrance

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