Biosynthesis of Brain Gangliosides

  • R. Caputto
  • H. J. Maccioni
  • A. Arce
  • F. A. Cumar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)


The pathways of synthesis of brain gangliosides have been inferred from results of usual enzymic experiments in which all the substrates are from exogenous origen and from results of experiments in which endogenous acceptors present in subcellular membranes are labelled by using exogenous, water soluble donors. For the synthesis of most gangliosides the results obtained with both methods are in agreement but in the synthesis of GDIb they are discrepant. The pathways obtained with each method are summarized in Fig. 1a and 1b. In the present communication we will deal preferentially with progress made in this field since the ganglioside conference at Strasbourg in 1973 (see ref. 12).


Sialic Acid Specific Radioactivity Brain Ganglioside Subcellular Membrane Transient Intermediate 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • R. Caputto
    • 1
  • H. J. Maccioni
    • 1
  • A. Arce
    • 1
  • F. A. Cumar
    • 1
  1. 1.Departamento de Química Biológica, Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina

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