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Biosynthesis of Brain Gangliosides

  • R. Caputto
  • H. J. Maccioni
  • A. Arce
  • F. A. Cumar
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)

Abstract

The pathways of synthesis of brain gangliosides have been inferred from results of usual enzymic experiments in which all the substrates are from exogenous origen and from results of experiments in which endogenous acceptors present in subcellular membranes are labelled by using exogenous, water soluble donors. For the synthesis of most gangliosides the results obtained with both methods are in agreement but in the synthesis of GDIb they are discrepant. The pathways obtained with each method are summarized in Fig. 1a and 1b. In the present communication we will deal preferentially with progress made in this field since the ganglioside conference at Strasbourg in 1973 (see ref. 12).

Keywords

Sialic Acid Specific Radioactivity Brain Ganglioside Subcellular Membrane Transient Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hammarström, S. (1970) Biochem. Biophys.Res.Commun. 45, 459.CrossRefGoogle Scholar
  2. 2.
    Brady, R.O. (1962) J.Biol.Chem. 237, 2416.Google Scholar
  3. 3.
    Hammarstrom, S. (1972) FEBS Letters, 21, 259.CrossRefGoogle Scholar
  4. 4.
    Ullman, M.D. and Radin, N.S. (1972) Arch.Biochem. Biophys., 152, 767.CrossRefGoogle Scholar
  5. 5.
    Curtino, J.A., and Caputto, R. (1974) Biochem.Biophys. Res.Commun., 56, 142.CrossRefGoogle Scholar
  6. 6.
    Arce, A., Maccioni, H.J. and Caputto, R. (1971) Biochem. J. 121, 483.Google Scholar
  7. 7.
    Arce, A., Maccioni, H.J. and Caputto, R. (1972) Anales Asoc.Quím.Argentina, 60, 185.Google Scholar
  8. 8.
    Cumar, F.A., Fishman, P.H and Brady, R.O. (1971) J.Biol.Chem., 246, 5075.Google Scholar
  9. 9.
    Cumar, F.A., Tallman, J.F. and Brady, R.O. (1972) J.Biol.Chem., 247, 2322.Google Scholar
  10. 10.
    Mestrallet, M.G., Cumar, F.A. and Caputto, R. (1974) Biochem.Biophys.Res.Commun., 59, 1.CrossRefGoogle Scholar
  11. 11.
    Mestrallet, M.G., and Cumar, F.A. (1974) abstr. X Reunión Nacional de la Sociedad Argentina de Investiga-ción Bioquímica, Buenos Aires, Argentina, p.17.Google Scholar
  12. 12.
    Caputto, R., Maccioni, H.J., and Arce, A. (1974) Mol. Cell.Biochem. 4, 97.CrossRefGoogle Scholar
  13. 13.
    Maccioni, H.J., Arce, A., and Caputto, R. (1971) Biochem.J., 125, 1131.Google Scholar
  14. 14.
    Schachter, H., Jabbal, I., Hudgin, R.L., Pinteric, L., McGuire, E.J. and Roseman, S. (1970) J.Biol.Chem. 245, 1090.Google Scholar
  15. 15.
    Keenan, T.W., Morré, J.D. and Basu, S. (1974) J.Biol. Chem., 249, 310.Google Scholar
  16. 16.
    Forman, D.S. and Ledeen, R.V. (1972) Science, N.Y., 177, 630.CrossRefGoogle Scholar
  17. 17.
    Maccioni, H.J., Arce, A., Landa, C. and Caputto, R. (1974) Biochem.J., 138, 291.Google Scholar
  18. 18.
    Landa C., Maccioni, H.J. and Arce, A. (1975) abstr. XI Reunión Nacional de la Sociedad Argentina de Inves tigación Bioquímica, Alta Gracia, Argentina, N°27.Google Scholar
  19. 19.
    Whittaker, V.P., Michaelson, I.A. and Kirkland, R.J. A., (1964) Biochem.J., 90, 293.Google Scholar
  20. 20.
    Fishman, P.H., Max, S.R., Tallman, J.F., Brady, R.O., Maclaren, N.K. and Corn blath, M. (1975) Science, N.Y.. 187, 68.CrossRefGoogle Scholar
  21. 21.
    Cumar, F.A., Brady, R.O., Kolodny, E.H., Mc Farland, V.W. and Mora, P.T. (1970) Proc.Nat.Acad.Sci. USA., 67, 757.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • R. Caputto
    • 1
  • H. J. Maccioni
    • 1
  • A. Arce
    • 1
  • F. A. Cumar
    • 1
  1. 1.Departamento de Química Biológica, Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina

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