On a Molecular, Microscale Fingerprinting of Gangliosides
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Mass spectrometry of intact ganglioside derivatives has been shown to afford a specific information on type, number and sequence of sugars, as well as ceramide structure. This is illustrated here for a hematoside with N-glycolylneuraminic acid and a di-sialyldihexosylceramide. As shown elsewhere, this novel technique, needing only 10 micrograms for a spectrum, is generally applicable to all types of glycolipids, including complex blood group fuco-lipids.
KeywordsSialic Acid Amino Sugar Neuraminic Acid Lignoceric Acid Major Molecular Species
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