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Effects of Brain Gangliosides on Functional Recovery in Experimental Regeneration and Reinnervation

  • B. Ceccarelli
  • F. Aporti
  • M. Finesso
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)

Abstract

There is now an increasing body of evidence to support the idea that Cns and Pns gangliosides may play an important functional role in various nervous tissues although their precise role has not yet been elucidated. There is also good biochemical evidence that gangliosides are highly concentrated in the nerve terminals, most of them associated with the nerve terminal plasma membrane (Burton, 1976; De Robertis et al. 1976; Morgan et al. 1976), nevertheless any clear relationship between the subcellular distribution of gangliosides within the different nerve terminal membranes and the normal chain of events involved in transmitter release and the overall synaptic economy has not been yet established. In spite of these uncertainties we thought that it might be useful to test the effects of gangliosides during the process of nerve regeneration and reinnervation of target tissues.

Keywords

Functional Recovery Untreated Animal Superior Cervical Ganglion Nictitate Membrane Ocular Sign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • B. Ceccarelli
    • 1
  • F. Aporti
    • 2
  • M. Finesso
    • 2
  1. 1.Department of Pharmacology C.N.R. Center of CytopharmacologyUniversity of MilanoMilanoItaly
  2. 2.Fidia Res.LaboratoryAbano TermePadovaItaly

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