Abstract
Many of the investigators who have contributed to the development of our understanding of the structure and function of the brain gangliosides and related brain mucoids have summarized their areas in this meeting, and in the space available I shall attempt to summarize our work in the field. This work has ranged from the demonstration of the first effective in vivo therapeutic use of brain gangliosides against the neurotoxicity of both influenza PR8 and NWS viruses (6) (an “active” pharmacological property), to the demonstration that the brain glycoprotein hexose concentration decreases in response to a “Distance Factor” in the presence of a brain tumor growing subcutaneously, and increases when the distant tumor growth is retarded with diphenylhydantoin (30) (a “passive” property).
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Bogoch, S. (1976). History of Recognition Molecules in the Brain. In: Porcellati, G., Ceccarelli, B., Tettamanti, G. (eds) Ganglioside Function. Advances in Experimental Medicine and Biology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4614-9_15
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