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History of Recognition Molecules in the Brain

With Special Reference to the Pharmacology of Brain Gangliosides
  • Samuel Bogoch
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)

Abstract

Many of the investigators who have contributed to the development of our understanding of the structure and function of the brain gangliosides and related brain mucoids have summarized their areas in this meeting, and in the space available I shall attempt to summarize our work in the field. This work has ranged from the demonstration of the first effective in vivo therapeutic use of brain gangliosides against the neurotoxicity of both influenza PR8 and NWS viruses (6) (an “active” pharmacological property), to the demonstration that the brain glycoprotein hexose concentration decreases in response to a “Distance Factor” in the presence of a brain tumor growing subcutaneously, and increases when the distant tumor growth is retarded with diphenylhydantoin (30) (a “passive” property).

Keywords

Superior Cervical Ganglion Recognition Molecule Neuraminic Acid Brain Ganglioside Ganglionic Transmission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Samuel Bogoch
    • 1
    • 2
    • 3
  1. 1.Dreyfus Medical FoundationNew YorkUSA
  2. 2.Foundation for Research on the Nervous SystemBostonUSA
  3. 3.Boston University School of MedicineBostonUSA

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