The Relationship Between the Action of Tetanus Toxin and its Binding by Membranes and Gangliosides

  • Jane Mellanby
  • Diana Pope
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)


Tetanus toxin binds to synaptic membranes and to purified gan-gliosides in vitro (van Heyningen, 1959, a, b, c). Two questions have frequently arisen: 1) are gangliosides responsible for the binding of tetanus toxin to nervous tissue?; and 2) does toxin binding play a role in the lethal action of the toxin?


Botulinum Toxin Nervous Tissue Synaptic Membrane Tetanus Toxin Toxin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ambache, N., Morgan, R. S. and Wright, G. Payling (1948). J. Physiol., 107, 45–53. The action of tetanus toxin on the rabbit’s iris.Google Scholar
  2. Carter, H.E. and Fujino, Y. (1956). J. biol. Chem., 221, 879–884. Biochemistry of the sphingolipids. Ix. Configuration of the cerebrosides.Google Scholar
  3. Coleman, G.E. (1924). J. infect. Dis., 34, 614. Action of leucocytes and of brain tissue on toxin of B. botulinus.CrossRefGoogle Scholar
  4. Habermann, E. and Heller, I. (1975). Naunyn-Schmiedeberg’s Arch. Pharmacol., 287, 97–106. Direct evidence for the specific fixation of Ci. botulinum A Neurotoxin to brain matter.Google Scholar
  5. Mellanby, J.H., Pope, D. and Ambache, N. (1968). J. gen. microbiol., 50, 479–486. The effect of the treatment of crude tetanus toxin with gangliosidercerebroside complex on sphincter paralysis in the rabbit eye.CrossRefGoogle Scholar
  6. Mellanby, J.H., Thompson, P.A. and Hampden, N. (1973). Naunyn-Schmiedeberg’s Arch. Pharmacol., 276, 303–310. On the similarity of tetanus and botulinum toxins.CrossRefGoogle Scholar
  7. Mellanby, J.H. and Whittaker, V. P. (1968). J. Neurochem., 15, 205–208. The fixation of tetanus toxin by synaptic membranes.CrossRefGoogle Scholar
  8. van Heyningen, W.E. (1959, a). J. gen. microbiol. 20, 291. The fixation of tetanus toxin by nervous tissue.CrossRefGoogle Scholar
  9. van Heyningen, W.E. (1959, b). J. gen. Microbiol. 20, 301. Chemical assay of the tetanus toxin receptor in nervous tissue.CrossRefGoogle Scholar
  10. van Heyningen, W.E. (1959, c). J. gen. Microbiol. 20, 310. Tentative identification of the tetanus toxin receptor in nervous tissue.CrossRefGoogle Scholar
  11. van Heyningen, W. E. (1974). Nature, 249, 415. Gangliosides as membrane receptors for tetanus toxin, cholera toxin and serotonin.CrossRefGoogle Scholar
  12. van Heyningen, W.E. and Mellanby, J.H. (1968). J. gen. Microbiol. 52, 447. The effect of cerebroside and other lipids on the fixation of tetanus toxin by ganglioside.CrossRefGoogle Scholar
  13. van Heyningen, W.E. and Mellanby, J.H. (1973). Naunyn-Schmiedeberg’s Arch. Pharmacol., 276, 297–302. A note on the specific fixation, specific deactivation and non-specific inactivation of bacterial toxins by gangliosides.CrossRefGoogle Scholar
  14. Whittaker, V. P., Michaelson, I.A., and Kirkland, R.J.A. (1964). Biochem. J., 90, 293. The separation of synaptic vesicles from nerve-ending particles (‘Synaptosomes’).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Jane Mellanby
    • 1
  • Diana Pope
    • 1
  1. 1.Department of Experimental PsychologyUniversity of OxfordOxfordEngland

Personalised recommendations