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Retinal Gangliosides: Composition, Evolution with Age. Biosynthetic and Metabolic Approaches

  • H. Dreyfus
  • P. F. Urban
  • S. Harth
  • A. Preti
  • P. Mandel
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)

Abstract

Gangliosides are a complex group of glycosphingolipids which contain one or more molecules of sialic acid. They are localized in a rather high amount and with a great diversity in cytoplasmic membranes of neurones especially in synaptosomes and membranes of microsomes (1–3). Gangliosides contain a sphingosine base, a fatty acid and at least one mole of hexose and sialic acid. The functional role of gangliosides is poorly understood, despite their early discovery by Klenk in metabolic disorders causing neurological diseases, named gangliosidoses (4). The accumulation of gangliosides in the metabolic disorders have been related to the disturbance in the enzymes involved in their metabolism (5).

Keywords

Sialic Acid Embryonic Life Rabbit Retina Chick Retina Brain Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • H. Dreyfus
    • 1
    • 2
  • P. F. Urban
    • 1
    • 2
  • S. Harth
    • 1
    • 2
  • A. Preti
    • 1
    • 2
  • P. Mandel
    • 1
    • 2
  1. 1.Centre de Neurochimie du CNRSStrasbourg CedexFrance
  2. 2.Department of Biological Chemistry, Medical SchoolUniversity of MilanItaly

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