Skip to main content
SpringerLink
Log in
Book cover

Ganglioside Function pp 163–188Cite as

Retinal Gangliosides: Composition, Evolution with Age. Biosynthetic and Metabolic Approaches

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 71))

Abstract

Gangliosides are a complex group of glycosphingolipids which contain one or more molecules of sialic acid. They are localized in a rather high amount and with a great diversity in cytoplasmic membranes of neurones especially in synaptosomes and membranes of microsomes (1–3). Gangliosides contain a sphingosine base, a fatty acid and at least one mole of hexose and sialic acid. The functional role of gangliosides is poorly understood, despite their early discovery by Klenk in metabolic disorders causing neurological diseases, named gangliosidoses (4). The accumulation of gangliosides in the metabolic disorders have been related to the disturbance in the enzymes involved in their metabolism (5).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lapetina E.G., Soto E.F. and De Robertis E. (1967) Bioohim. Biophys. Acta135, 33.

    Article  Google Scholar 

  2. Wiegandt H. (1967) J. Neuroohem.14, 671.

    Article  Google Scholar 

  3. Morgan I.G., Wolfe L.S., Mandel P. and Gombos G. (1971) Bioohim. Biophys. Acta241, 737.

    Article  Google Scholar 

  4. Klenk E. (1939) Z. Physiol. Chem.262, 128.

    Article  Google Scholar 

  5. Brady R.O. and Kolodny E.H. (1972) Progr. Medical Genetic, vol. Viii, p.225.

    Google Scholar 

  6. Kuhn R., Wiegandt H. and Egge H. (1961) Angew. Chem.73, 580.

    Article  Google Scholar 

  7. Svennerholm L. (1964) J. Lipid Res.5, 145.

    Google Scholar 

  8. Ledeen R. (1966) J. Am. Oil Chem. Soc.43, 57.

    Article  Google Scholar 

  9. Wiegandt H. (1968) Angew. Chem. Int. Ed. Enyl.7, 87.

    Article  Google Scholar 

  10. Klenk E. (1969) Progr. Chem. Fats other lipids 10, part 4, 411.

    Article  Google Scholar 

  11. Svennerholm L. (1970) in Handbook of Beuro chemistry, ed. A. Lajtha, Plenum Publ., New York, vol. 3, p. 425.

    Google Scholar 

  12. Ledeen R.W. and Yu R.K. (1973) in Lysosomes and storage diseases, eds. H.G. Hers and F. Van Hoff, Acad. Press, N.Y., p. 105.

    Google Scholar 

  13. Kuhn R. and Wiegandt H. (1963) Chem. Ber.96, 866.

    Article  Google Scholar 

  14. Svennerholm L. (1963) J. Neuroohem.10, 613.

    Article  Google Scholar 

  15. Johnson G.A. and McCluer R.H. (1963) Bioohim. Biophys. Acta70, 487.

    Article  Google Scholar 

  16. Klenk E. and Gielen W. (1963) Z. Physiol. Chem.330, 218.

    Article  Google Scholar 

  17. Korey S.R. and Gonatas J. (1963) Life Sci. 1, 296.

    Article  Google Scholar 

  18. Ishizuka I. and Wiegandt H. (1972) Bioohim. Biophys. Acta260, 279.

    Article  Google Scholar 

  19. Svennerholm L., Månsson, J.E. and Li Y.T. (1973) J. Biol. Chem.248, 740.

    Google Scholar 

  20. Li Y.T., Månsson J.E., Vanier M.T. and Svennerholm L. (1973) J. Biol. Chem.248, 2634.

    Google Scholar 

  21. Ledeen R.W., Yu R.K. and Eng L.F. (1973) J. Neuroohem.21, 829.

    Article  Google Scholar 

  22. Svennerholm L. (1964) J. Neuroohem.11, 839.

    Article  Google Scholar 

  23. Suzuki K. (1965) J. Neuroohem.12, 969.

    Article  Google Scholar 

  24. Merat A. and Dickerson J.W.T. (1973) J. Neuroohem.20, 873.

    Article  Google Scholar 

  25. Jourdian G.W. and Roseman S. (1963) Ann. N.Y. Acad. Sci.106, 202.

    Article  Google Scholar 

  26. Basu S., Kaufman B. and Roseman S. (1973) J. Biol. Chem.248, 1388.

    Google Scholar 

  27. Arce A., Maccioni H.F. and Caputto R. (1966) Arch. Biochem. Biophys.116, 52.

    Article  Google Scholar 

  28. Dain J.A., Di Cesare J.L., Yip M.C.M. and Weicker H. (1973) in Glycolipids, Glycoproteins and Mucopolysaccharides of the Nervous System, eds. V. Zambotti, J. Tettamanti and M. Arigoni, Plenum Publ., New York, p. 151.

    Google Scholar 

  29. Fishman P.H. (1974) Chem. Phys. Lipids13, 305.

    Article  Google Scholar 

  30. Roseman S. (1970) Chem. Phys. Lipids5, 270.

    Article  Google Scholar 

  31. Sjöstrand F.S. (1958) Ergekn. Biol.21, 128.

    Google Scholar 

  32. Hörnhammer L., Wagner H. and Wolff R. (1960) Z. Physiol. Chem. 319, 7.

    Article  Google Scholar 

  33. Lowry O.H., Roberts N.R. and Lewis C. (1956) J. Biol. Chem.220, 879.

    Google Scholar 

  34. Handa S. and Burton R.M. (1969) Lipids4, 205.

    Article  Google Scholar 

  35. Kostic D., Urban P.F., Lemieux B. and Mandel P. (1969) Bull. Soc. Chim. Biol.51, 1632.

    Google Scholar 

  36. Hess H.H., Stoffyn P. and Sprinkle K. (1971) 3rd Intern. Meeting Neuroehem., Budapest, Abstr. p. 295.

    Google Scholar 

  37. Holm M., Månsson J.E., Vanier M.T. and Svennerholm L. (1972) Bioohim. Biophys. Acta280, 356.

    Article  Google Scholar 

  38. Holm M. and Månsson J.E. (1974) FEBS Lett. 38, 261.

    Article  Google Scholar 

  39. Holm M. (1972) J. Neuroehem.19, 623.

    Article  Google Scholar 

  40. Holm M. and Månsson J.E. (1974) FEBS Lett. 46, 200.

    Article  Google Scholar 

  41. Edel-Harth S., Dreyfus H., Bosch P., Rebel G., Urban P.F. and Mandel P. (1973) FEBS Lett. 35, 284.

    Article  Google Scholar 

  42. Urban P.F., Edel-Harth S. and Dreyfus H, (1975) Exptl. Eye Res.20, 397.

    Article  Google Scholar 

  43. Dreyfus H., Urban P.F., Bosch P., Edel-Harth S., Rebel G. and Mandel P. (1974) J. Neurochem.22, 1073.

    Article  Google Scholar 

  44. Dreyfus H., Urban P.F., Edel-Harth S. and Mandel P. (1975) J. Neuroehem.25, 245.

    Article  Google Scholar 

  45. Dreyfus H., Urban P.F., Edel-Harth S. and Mandel P. (1975) 10th FEBS Meeting, Paris, Abstr. n° 1008.

    Google Scholar 

  46. Dreyfus H., Urban P.F., Edel-Harth S., Neskovic N.M. and Mandel P. (1975) Lipids, in press.

    Google Scholar 

  47. Dreyfus H., Edel-Harth S., Neskovic N. and Urban P.F. (1975) 5th Intern Meeting Neuroehem., Barcelona, Abstr. n° 362.

    Google Scholar 

  48. Dreyfus H., Edel-Harth S., Urban P.F. and Preti A. (1975) Association Physiologistes, Lyon, Sept.

    Google Scholar 

  49. Lowry O.H., Rosebrough N.J., Farr A.L. and Randall R.J. (1951) J. Biol. Chem.193, 265.

    Google Scholar 

  50. Suzuki K. (1964) Life Sci. 3, 1227.

    Article  Google Scholar 

  51. Miettinen T. and Takki-Luukkainen I.T. (1959) Aeta Chem. Seand.13, 856.

    Article  Google Scholar 

  52. Van Den Eijnden D.H. (1971) Z. Physiol. Chem.352, 1601.

    Google Scholar 

  53. Svennerholm L. (1967) Bioehim. Biophys. Acta24, 604.

    Article  Google Scholar 

  54. Folch J., Lees M. and Sloane Stanley G.H. (1957) J. Biol. Chem.226, 497.

    Google Scholar 

  55. Kean E.L. (1966) J. Lipid Res.7, 449.

    Google Scholar 

  56. Dodge J.T. and Philips G.B. (1967) J. Lipid Res.8, 667.

    Google Scholar 

  57. Urban P.F., Dreyfus H., Neskovic N. and Mandel P. (1973) J. Neuroehem.20, 325.

    Article  Google Scholar 

  58. Tettamanti G. and Zambotti V. (1968) Enzymologia35, 61.

    Google Scholar 

  59. Preti A., Lombardo A. and Tettamanti G. (1970) Ital. J. Biochem.19, 371.

    Google Scholar 

  60. Warren L. (1959) J. Biol. Chem.234, 1971.

    Google Scholar 

  61. Witkowski P. (1963) Vision Res. 3, 341.

    Article  Google Scholar 

  62. Basu S., Kaufman B. and Roseman S. (1968) J. Biol. Chem.243, 5802.

    Google Scholar 

  63. Hildebrand J., Stoffyn P. and Hauser G. (1970) J. Neuroehem.17, 403.

    Article  Google Scholar 

  64. Neskovic N.M., Sarliève L.L. and Mandel P. (1972) Brain Res. 42, 147.

    Article  Google Scholar 

  65. Brenkert A. and Radin N.S. (1972) Brain Res. 36, 183.

    Article  Google Scholar 

  66. Morell P. and Radin N.S. (1969) Biochemistry8, 506.

    Article  Google Scholar 

  67. Neskovic N.M., Sarliève L.L. and Mandel P. (1974) Biochim. Biophys. Acta334, 309.

    Article  Google Scholar 

  68. Shah S.N. (1971) J. Neuroohem.18, 395.

    Article  Google Scholar 

  69. Esselman W.J., Laine R.A. and Sweeley C.C. (1972) in Methods of Enzymology, Vol. Xxviii, Part B, p. 140.

    Google Scholar 

  70. Svennerholm L. (1956) J. Neuroohem.1, 42.

    Article  Google Scholar 

  71. Avrova N.F. (1971) J. Neuroohem.18, 665.

    Google Scholar 

  72. Hughes W.F. and La Velle A. (1974) Anat. Res.179, 297.

    Article  Google Scholar 

  73. Olney J.W. (1968) Invest. Ophthalmol.7, 250.

    Google Scholar 

  74. Ookawa T. and Takahashi K. (1971) Experientia27, 407.

    Article  Google Scholar 

  75. Vanier M.T., Holm M., Öhman R. and Svennerholm L. (1971) J. Neuroohem.18, 581.

    Article  Google Scholar 

  76. Arce A., Maccioni H. and Caputto R. (1971) Bioohem. J.121, 483.

    Google Scholar 

  77. Yip M.C.M. and Dain J.A. (1969) Lipids4, 270.

    Article  Google Scholar 

  78. Harzer K., Jatzkewitz H. and Sandhoff K. (1969) J. Neuroohem.16, 1279.

    Article  Google Scholar 

  79. Kanfer J.N. and Richards R.L. (1967) J. Neuroohem.14, 513.

    Article  Google Scholar 

  80. Kolodny E.H., Brady R.O., Quirck J.M. and Kanfer J.N. (1970) J. Lipid Res.11, 144.

    Google Scholar 

  81. Quarles R.H. and Brady R.O. (1971) J. Neuroohem.18, 1809.

    Article  Google Scholar 

  82. Rösner H., Wiegandt H. and Rahmann H. (1973) J. Neuroohem.21, 655.

    Article  Google Scholar 

  83. Suzuki K. and Korey S.R. (1964) J. Neuroohem.11, 647.

    Article  Google Scholar 

  84. Arce A., Maccioni H.J. and Caputto R. (1970) Federation Proo. 29, 410.

    Google Scholar 

  85. Holm M. and Svennerholm L. (1972) J. Neuroohem.19, 609.

    Article  Google Scholar 

  86. Maccioni H.J., Arce A, and Caputto R. (1971) Bioohem. J.125, 1131.

    Google Scholar 

  87. Tettamanti G., Bonali F., Sonnino S. and Zambotti V. (1974) Experientia (Basel)30, 330.

    Article  Google Scholar 

  88. Maccioni A.H.R., Gimenez M.S. and Caputto R. (1971) J. Neuroohem.18, 2363.

    Article  Google Scholar 

  89. Roseman S., unpublished results.

    Google Scholar 

  90. Suzuki K. (1965) J. Neuroohem.12, 969.

    Article  Google Scholar 

  91. Drzeniek R. (1973) Histochemical J. 5, 271.

    Article  Google Scholar 

  92. Cook B. and Ada G.L. (1963) Biochim. Biophys. Acta73, 454.

    Article  Google Scholar 

  93. Tulsiani D.R.P., Nordquist R.E. and Carubelli R. (1973) Exptl. Eye Res.15, 93.

    Article  Google Scholar 

  94. Leibovitz Z. and Gatt S. (1968) Biochim. Biophys. Acta152, 136.

    Article  Google Scholar 

  95. Di Donato S. and Tettamanti G. (1967) Boll. Soo. Ital. Biol. Sper.43, 1032.

    Google Scholar 

  96. Ohman R., Rosenberg A. and Svennerholm L. (1970) Biochemistry9, 3774.

    Article  Google Scholar 

  97. Schengrund C.L. and Rosenberg A. (1970) J. Biol. Chem.245, 6196.

    Google Scholar 

  98. Tettamanti G., Preti A., Lombardo A., Gasparini M. and Zam-botti V. (1972) Biochim. Biophys. Acta258, 228.

    Article  Google Scholar 

  99. Tettamanti G., Morgan I.G., Gombos G., Vincendon G. and Mandel P. (1972) Brain Res. 47, 515.

    Article  Google Scholar 

  100. Schengrund C.L. and Rosenberg A. (1971) Biochemistry10, 2424.

    Article  Google Scholar 

  101. Dreyfus H. and Preti A., unpublished data.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre de Neurochimie du CNRS, 11 Rue Humann, 67085, Strasbourg Cedex, France

    H. Dreyfus, P. F. Urban, S. Harth, A. Preti & P. Mandel

  2. Department of Biological Chemistry, Medical School, University of Milan, Italy

    H. Dreyfus, P. F. Urban, S. Harth, A. Preti & P. Mandel

Authors
  1. H. Dreyfus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. F. Urban
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Harth
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Preti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Mandel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Medical School, University of Perugia, Perugia, Italy

    Giuseppe Porcellati

  2. The Medical School, University of Milan, Milan, Italy

    Bruno Ceccarelli  & Guido Tettamanti  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer Science+Business Media New York

About this chapter

Cite this chapter

Dreyfus, H., Urban, P.F., Harth, S., Preti, A., Mandel, P. (1976). Retinal Gangliosides: Composition, Evolution with Age. Biosynthetic and Metabolic Approaches. In: Porcellati, G., Ceccarelli, B., Tettamanti, G. (eds) Ganglioside Function. Advances in Experimental Medicine and Biology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4614-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-4614-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2656-2

  • Online ISBN: 978-1-4614-4614-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation