Structure and Specificity of Gangliosides
- 31 Downloads
The name gangliosides was coined by E. Klenk (1) for the class of sialoglycosphingolipids which he had discov ered to be highly concentrated in the ganglion cells of the central nervous system. It was in fact this localiz ation and in addition the pathological accumulation of the gangliosides in Tay-Sachs and similar storage diseases, which much stimulated the early interest of research in this field (for review see (2)). The distinguishing molecular constituent of the gangliosides, of course, is the sialic acid. It is known now that the var iously substituted neuraminic acids indeed function in various highly important biological phenomena (3) and one may expect gangliosides frequently to be involved. It is, however, still not sufficiently clear in how far the gangliosides do in fact serve biological functions different from their relatives, the neutral glycosphin-golipids (for review see (4)). The gangliosides and neu tral glycosphingolipids contribute to the specific oligosaccharide structures located at the outer cell surface, which have long been implicated in processes of membrane mediated information (Lit.cit.in 5). Special significance was attributed to the surface carbohydrates in events of cell to cell contact (6) and the altered growth behaviour of transformed cells (7).
KeywordsSialic Acid Adenylate Cyclase Cholera Toxin Neuraminic Acid Blood Group Substance
Unable to display preview. Download preview PDF.
- 4).Wiegandt, H. (1971) Adv. Lipid Res. 9, 249.Google Scholar
- 5).Wiegandt, H. (1975) in Biomembranes, Lipids, Proteins and Receptors, Edt. R.M. Burton and F.S. Esters, NATO-Advanced Study Institute, Bi-Science Publ. Div. Webster Groves Missouri.Google Scholar
- 7).Hakomori, S.-J. (1975) Biochim.Biophys.Acta 417, 55.Google Scholar
- 13).Craig, S.W. and P. Cuatrecasas (1975) Fed. Proc. 34, 584 Abstr. 2068.Google Scholar
- 15).King, M.E., D.W. King, L. Graf and M.M. Kapport (1974) Fed.Proc. 33, Abstr. 23. Laine, R.A. and S.-J.Hakomori (1973) Biochem.Biophys.Res.Comm. 54, 1039.Google Scholar
- 18).Yogeeswaran, R., Sheinin, J., Wherrettand, R., Murray, R.K. (1972) J. Biol. Chem. 247 5146.Google Scholar
- 22).Finkelstein, R.A., M. Boesman, S.H. Neoh, M.K. La Rue and R. Delaney (1974) J. Immunol. 113, 145. Lönnroth, J. and J. Holmgren (1973) J. Gen. Microbiol. 76, 417.Google Scholar
- 23).Van Heyningen, S. and A.C. King (1975) Biochem. J. 146, 269. Van Heyningen, S. (1974) Science, 183, 656.Google Scholar
- 25).Wiegandt, H., J. Stärk, H.-J. Ronneberger and W. Ziegler (1975) Manuscript in preparation.Google Scholar
- 26).Wiegandt, H., H.H. Sedlacek, F.R. Seiler and W. Ziegler (1975) Manuscript in preparation.Google Scholar