Structure and Specificity of Gangliosides

  • Herbert Wiegandt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 71)


The name gangliosides was coined by E. Klenk (1) for the class of sialoglycosphingolipids which he had discov ered to be highly concentrated in the ganglion cells of the central nervous system. It was in fact this localiz ation and in addition the pathological accumulation of the gangliosides in Tay-Sachs and similar storage diseases, which much stimulated the early interest of research in this field (for review see (2)). The distinguishing molecular constituent of the gangliosides, of course, is the sialic acid. It is known now that the var iously substituted neuraminic acids indeed function in various highly important biological phenomena (3) and one may expect gangliosides frequently to be involved. It is, however, still not sufficiently clear in how far the gangliosides do in fact serve biological functions different from their relatives, the neutral glycosphin-golipids (for review see (4)). The gangliosides and neu tral glycosphingolipids contribute to the specific oligosaccharide structures located at the outer cell surface, which have long been implicated in processes of membrane mediated information ( 5). Special significance was attributed to the surface carbohydrates in events of cell to cell contact (6) and the altered growth behaviour of transformed cells (7).


Sialic Acid Adenylate Cyclase Cholera Toxin Neuraminic Acid Blood Group Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Klenk, E. (1942) H.-Ss. Zschft. Physiol. Chem. 273, 76.CrossRefGoogle Scholar
  2. 2).
    Wiegandt, H. (1968) Angew. Chem. 80, 89; Int. Ed. 7, 87.CrossRefGoogle Scholar
  3. 3).
    Schauer, R. (1973) Angew. Chem. 85, 128; Int. Ed. 12.CrossRefGoogle Scholar
  4. 4).
    Wiegandt, H. (1971) Adv. Lipid Res. 9, 249.Google Scholar
  5. 5).
    Wiegandt, H. (1975) in Biomembranes, Lipids, Proteins and Receptors, Edt. R.M. Burton and F.S. Esters, NATO-Advanced Study Institute, Bi-Science Publ. Div. Webster Groves Missouri.Google Scholar
  6. 6).
    Roseman, S. (1970) Chem. Phys. Lipids 5, 270.CrossRefGoogle Scholar
  7. 7).
    Hakomori, S.-J. (1975) Biochim.Biophys.Acta 417, 55.Google Scholar
  8. 8).
    Da Silva, P. and Martinez-Palomo, A. (1975) Proc. Nat. Acad. Sei. 72, 572, Ref. 2–7.CrossRefGoogle Scholar
  9. 9).
    Keenan, T.W., W.W. Franke and H. Wiegandt (1974) H.-Ss. Zschft. Physiol. Chem. 355, 1543.CrossRefGoogle Scholar
  10. 10).
    Stärk, J., H.J. Ronneberger, W. Ziegler and H. Wiegandt (1974) Eur. J. Biochem. 48, 103.CrossRefGoogle Scholar
  11. 11).
    Sattler, J., H. Wiegandt, J. Stärk, Th. Kranz, H.-J. Ronneberger, R. Schmidtberger and H. Zilg (1975) Europ. J. Biochem. 57, 309–316.CrossRefGoogle Scholar
  12. 12).
    Wiegandt, H. (1973) H.-Ss. Zschft. Physiol. Chem. 354, 1049.CrossRefGoogle Scholar
  13. 13).
    Craig, S.W. and P. Cuatrecasas (1975) Fed. Proc. 34, 584 Abstr. 2068.Google Scholar
  14. 14).
    Wiegandt, H. (1974) Europ. J. Biochem. 45, 367.CrossRefGoogle Scholar
  15. 15).
    King, M.E., D.W. King, L. Graf and M.M. Kapport (1974) Fed.Proc. 33, Abstr. 23. Laine, R.A. and S.-J.Hakomori (1973) Biochem.Biophys.Res.Comm. 54, 1039.Google Scholar
  16. 16).
    Brailovsky, C., M. Trudel, R. Lallier and N.V. Nigam (1973) J. Cell. Biol. 57, 124.CrossRefGoogle Scholar
  17. 17).
    Keenan, T.W., E. Schmidt, W.W. Franke and H. Wiegandt (1975) Exptl. Cell. Res. 92, 259.CrossRefGoogle Scholar
  18. 18).
    Yogeeswaran, R., Sheinin, J., Wherrettand, R., Murray, R.K. (1972) J. Biol. Chem. 247 5146.Google Scholar
  19. 19).
    Van Heningen, W.E., Carpenter, C.J., Pierce, N.F. and Greenough III, W.B. (1971) J. Infect. Dis. 124, 415.CrossRefGoogle Scholar
  20. 20).
    Kuhn, R. and H. Wiegandt (1963) Chem. Ber. 96, 866.CrossRefGoogle Scholar
  21. 21).
    Finkelstein, R.A. (1973) CRC Critical Reviews in Microbiol. 2, 553.CrossRefGoogle Scholar
  22. 22).
    Finkelstein, R.A., M. Boesman, S.H. Neoh, M.K. La Rue and R. Delaney (1974) J. Immunol. 113, 145. Lönnroth, J. and J. Holmgren (1973) J. Gen. Microbiol. 76, 417.Google Scholar
  23. 23).
    Van Heyningen, S. and A.C. King (1975) Biochem. J. 146, 269. Van Heyningen, S. (1974) Science, 183, 656.Google Scholar
  24. 24).
    Wiegandt, H. and W. Ziegler (1974) H.-Ss. Zschft. Physiol. Chem. 355, 11.CrossRefGoogle Scholar
  25. 25).
    Wiegandt, H., J. Stärk, H.-J. Ronneberger and W. Ziegler (1975) Manuscript in preparation.Google Scholar
  26. 26).
    Wiegandt, H., H.H. Sedlacek, F.R. Seiler and W. Ziegler (1975) Manuscript in preparation.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Herbert Wiegandt
    • 1
  1. 1.Physiologisch-Chemisches InstitutUniversität Marburg/Lahn.West Germany

Personalised recommendations