Abstract
Several very interesting papers dealing with the physiology of glucagon have been presented at this meeting and they bear witness to the revival of interest in glucagon which has taken place in the last few years. In order to summarize this work I recently found it necessary to read and, hopefully, digest more than 750 papers published since 1963 alone (Foà, 1967)*. Allow me then to follow the advice given by Professor Trabucchi in his opening address and attempt to give you a broad line summary of the problem, propose a few working hypotheses and suggest a possible physiologic role for glucagon, limiting to a minimum the presentation of new experimental data and the citation of old, although perhaps, in Dr. Guillemin’s words, “prophetic literature”. We have heard a great deal this morning about gastrointestinal glucagon.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
APPLEMAN, M. M., BIRNBAUMER, L. and TORRES, H. N. (1966): Factors affecting the activity of muscle glycogen synthetase. III. The reaction with adenosine triphosphate, Mg++, and cyclic 3′5′-adenosine monophosphate. Arch. Biochem. Biophys. 116, 39.
BEATTY, C. H., PETERSON, C. H., BOCEK, R. M., CRAIG, N. C. and WELEBER, R. (1963): Effect of glucagon on incorporation of glycine C14 into protein of voluntary skeletal muscle. Endocrinology, 73, 721.
BENEDETTI, A. and KOLB, F. O. (1966): Metabolic effects of glucagon and epinephrine in four adults with type I glycogen storage disease. Diabetes, 15, 529.
BISHOP, J. S. and LARNER, J. (1967): Rapid activation-inactivation of liver uridine diphosphate glucose-glycogen transferase and Phosphorylase by insulin and glucagon in vivo. J. Biol. Chem, 242, 1354.
DEVRIM, S. and RECANT, L. (1966): Effect of glucagon on insulin release in vitro. Lancet, 2, 1227.
EXTON, J. H. and PARK, C. R. (1966): The stimulation of gluconeogenesis from lactate by epinephrine, glucagon, and cyclic 3’, 5’-adenylate in the perfused rat liver. Pharmacol. Rev., 18, 181.
FOA, P. P. (1967): Glucagon. Erg. Physiol., in press.
FRIDLAND, A. and NIGAM, V. N. (1965): Effects of G6P, 2-deoxy-G6P and UMP on Phosphorylase and glycogen synthetase of pigeon liver. Arch, Biochem. Biophys., 111, 477.
GALANSINO, G., D’AMICO, G., KANAMEISHI, D., BERLINGER, F. G. and FOà, P. P. (1960): Hyperglycemic substances originating in the pancreato-duodenal area. Am. J. Physiol., 198, 1059.
GREENGARD, O. and BAKER, G. T. (1966): Glucagon, starvation, and the induction of liver enzymes by hydrocortisone. Science, 154, 1461.
GRODSKY, G. M. and BENNETT, L. L. (1966): Cation requirements for insulin secretion in the isolated perfused pancreas. Diabetes, 15, 910.
GRODSKY, G. M., BENNETT, L. L., SMITH, D. F. and SCHMID, F. G. (1967): Effect of pulse administration of glucose or glucagon on insulin secretion in vitro. Metabolism, 16, 222.
HALES, C. N. and RANDLE, P. J. (1963): Immunoassay of insulin with insulin-antibody precipitate. biochem. J., 88, 137.
JARETT, L. (1963): In vivo and in vitro effect of glucagon on DL-leucine-1-C14 incorporation into protein of rat pancreas. Proc. Soc. Exp. Biol. Med. (N.Y.), 114, 550.
KIBLER, R. F., TAYLOR, W. J. and MYERS, J. D. (1964): The effect of glucagon on net splanchnic balances of glucose, amino acid nitrogen, urea, ketones, and oxygen in man. J. Clin. Invest., 43, 904.
LARDY, H. A. (1964–65) : Gluconeogenesis — Pathways and hormonal regulation. Harvey Lecture Series, 60, 261.
LEFEBVRE, P. (1966): The physiological effect of glucagon on fat mobilization. Diabetologia, 2, 130.
MCLEAN, P. and NOVELLO, F. (1965): Influence of pancreatic hormones on enzymes concerned with urea synthesis in rat liver. Biochem. J., 94, 410.
NIEMEYER, H., N. PERéZ and RABAJILLE, E. (1966): Interrelation of actions of glucose, insulin, and glucagon on induction of adenosine triphosphate: D-hexose phosphotransferase in rat liver. J. Biol. Chem., 241, 4055.
PALOYAN, E., PALOYAN, D. and HARPER, P. V. (1967): Glucagoninduced hypocalcemia. Metabolism, 16, 35.
RANDLE, P. J., GARLAND, P. B., HALES, C. N., NEWSHOLME, E. A., DENTON, R. M. and POGSON, C. I. (1966): Interactions of metabolism and the physiological role of insulin. Recent Progress Hormone Res., 22, 1.
SALAS, M., VINUELA, E. and SOLS, A. (1963): Insulin-dependent synthesis of liver glucokinase in the rat. J. Biol. Chem.238, 3535.
SAMOLS, E., TYLER, J., MARRI, G. and MARKS, V. (1965): Stimulation of glucagon secretion by oral glucose. Lancet, ii, 1257.
SCHIMASSEK, H. (1967): Proceedings of this.meeting.
SCHIMASSEK, H. und MITZKAT, H. J. (1963): Über eine spezifische Wirkung des Glucagon auf die Embden-Meyerhof-Kette der Leber. Versuche an der isoliert perfundierten Rattenleber. Biochem., 337, 510.
SHIMA, K. and FOà, P. P. (1967): A double-antibody immunoassay for glucagon. In press.
SOKAL, J. E. (1966): Glucagon — An essential hormone. Am. J. Med., 41, 331
SUSSMAN, K. E. and VAUGHAN, G. D. (1967): Insulin release after ACTH, glucagon and adenosine-3’-5’-phosphate (cyclic AMP) in the perfused isolated rat pancreas. Diabetes, 16, 449.
SUTHERLAND, E. W. and ROBISON, G. A. (1966): The role of cyclic-3’, 5’-AMP in responses to catecholamines and other hormones. Pharmacol. Rev., 18, 145.
UNGER, R. H. and EISENTRAUT, A. M. (1964): Studies of the physiologic role of glucagon. Diabetes, 13, 563.
WHITTY, A. J., SHIMA, K., TRUBOW, M. and FOA, P. P. (1967): Effect of glucagon on serum FFA in normal and depancreatized dogs. Federation Proc, 26, 257.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1968 Springer Science+Business Media New York
About this chapter
Cite this chapter
Foà, P.P. (1968). The Physiologic Role of Glucagon. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_41
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4612-5_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-2726-2
Online ISBN: 978-1-4614-4612-5
eBook Packages: Springer Book Archive