Abstract
Pioneering studies by Sanger and co-workers in the period 1945–1955 led to the determination of the amino acid sequence and subsequently the overall structure of insulin from various species (1). This achievement, in conjunction with the earlier work of Banting and Best and of Abel, placed insulin in a unique place among the other proteins. It was one of the first proteins to be recognized as a hormone and thus forced the acceptance of the fact that a protein could be a hormone. It was the first protein whose structure has been elucidated and thus became the vanguard of protein structural analysis; and finally, from the discussion that will follow, it becomes apparent that insulin is the first protein to be chemically synthesized.
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References
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Katsoyannis, P.G. (1968). The Synthesis of Insulin. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_35
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DOI: https://doi.org/10.1007/978-1-4614-4612-5_35
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