The Synthesis of Insulin

  • Panayotis G. Katsoyannis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)

Abstract

Pioneering studies by Sanger and co-workers in the period 1945–1955 led to the determination of the amino acid sequence and subsequently the overall structure of insulin from various species (1). This achievement, in conjunction with the earlier work of Banting and Best and of Abel, placed insulin in a unique place among the other proteins. It was one of the first proteins to be recognized as a hormone and thus forced the acceptance of the fact that a protein could be a hormone. It was the first protein whose structure has been elucidated and thus became the vanguard of protein structural analysis; and finally, from the discussion that will follow, it becomes apparent that insulin is the first protein to be chemically synthesized.

Keywords

Cellulose Tyrosine Sodium Chloride Glycine Cysteine 

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Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Panayotis G. Katsoyannis
    • 1
  1. 1.Brookhaven National LaboratoryUptonUSA

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