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Pharmacology of Hormonal Polypeptides and Proteins pp 263–270Cite as

A Comparative Study on the Mouse Thyroid Ultrastructure after Stimulation with TSH and LATS

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 2))

Abstract

The biochemical structure and the immunological properties of the long-acting thyroid stimulator (LATS) and thyrotropin (TSH) are different (1), but their effects on the thyroidal iodine metabolism are similar, differing only in their time course (2, 3). Histologic studies have so far failed to show any major qualitative difference between the TSH and LATS stimulated thyroid glands. Both substances appear to affect in a similar manner the height of the thyroid follicular cells, the staining properties of the colloid (4) and the formation of intracellular colloid droplets (5). The similarities described above may suggest that TSH and LATS act on the thyroid gland through the same mechanism (6). In order to elucidate this problem, we have compared the ultrastructural changes induced by LATS and TSH in the thyroid of mice having their endogenous TSH secretion suppressed by the administration of thyroxine.

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References

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Authors and Affiliations

  1. I Istituto di Patologia Medica, University of Rome, Italy

    G. Tonietti, P. Liberti, L. Grasso & A. Pinchera

Authors
  1. G. Tonietti
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  2. P. Liberti
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  3. L. Grasso
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  4. A. Pinchera
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Editor information

Editors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

  2. Institute of Pharmacology, University of Milan, Milan, Italy

    Luciano Martini

  3. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

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© 1968 Springer Science+Business Media New York

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Tonietti, G., Liberti, P., Grasso, L., Pinchera, A. (1968). A Comparative Study on the Mouse Thyroid Ultrastructure after Stimulation with TSH and LATS. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_32

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  • DOI: https://doi.org/10.1007/978-1-4614-4612-5_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2726-2

  • Online ISBN: 978-1-4614-4612-5

  • eBook Packages: Springer Book Archive

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