The Mechanism of Action of Luteinizing Hormone on Steroidogenesis in the Corpus Luteum in Vitro
The interest of our laboratory for sometime, has been centered around the subject of ovarian steroidogenesis and its control by tropic hormones . I would like to present here some of the results we have obtained on one aspect of our work, namely, the study of the hormonal control of steroidogenesis in the corpus luteum. Historically the earliest demonstration of a hormonal influence on steroidogenesis in the corpus luteum was carried out using the rat, and it was found that prolactin was the luteotrop-ic agent in this animal (1). Subsequently it has become increasingly clear that prolactin is probably not luteotropic in several other species, such as the pig, the rabbit, the cow, and the human. In regard to the cow, there is considerable evidence from in vivo and in vitro studies to suggest that luteinizing hormone (LH) is the luteotropic hormone which regulates steroidogenesis in the corpus luteum (2).
KeywordsLuteinizing Hormone Thyroid Stimulate Hormone Corpus Luteum Steroid Synthesis Ovarian Steroidogenesis
Unable to display preview. Download preview PDF.
- 2.Hansel, W., J. Reprod. Fert., Suppl. 1, 33 (1966).Google Scholar
- 4.This was first observed by P. Major and D. Armstrong. Since then it has been confirmed by us. (unpublished results)Google Scholar
- 10.Sutherland, E. W., and Rall, T. W., Pharmacol. Revs., 12, 265 (1960).Google Scholar
- 12.Lowry, O. H., and Passonneau, J., Methods in Enzymology 4, 792 (1963).Google Scholar
- 13.Marsh, J. M., (unpublished results).Google Scholar