Abstract
Data are accumulating which indicate that nervous centers located above the hypothalamus may exert an inhibitory effect on the hypothalamic-pituitary-adrenal axis (Mangili/Motta and Martini/ 1966). It has been shown, for instance, that the interruption of all nervous pathways going to the hypothalamus from higher brain structures (“hypothalamic deafferentation”) results, in the rat, in a significant increase of adrenal weight (Halasz and Pupp, 1965) and of resting levels of plasma and adrenal corticosterone (Halasz, Slusher and Gorski/ 1967). Data obtained by Egdhal (1967) suggest that the cerebral cortex (CC) may be one of the structures involved in maintaining the hypothalamic-pituitary-adrenal axis under a constant tonic inhibition. He has shown that, in the dog, the surgical elimination of the CC brings about a significant increase of the secretory activity of the adrenal gland; consequentely, he has postulated that an inhibitory hormone, Opposite in effect to the hypothalamic Corticotropin Releasing Factor (CRF), is present in the CC.
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Lugaro, G., Casellato, M.M., Motta, M., Piva, F., Martini, L. (1968). Role of the Cerebral Cortex in the Control of Acth Secretion. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_21
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DOI: https://doi.org/10.1007/978-1-4614-4612-5_21
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