Studies on Luteinizing Hormone Releasing Factor (LRF) in Hypophysial Portal Blood of Rats

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)


In 1966 Worthington described a method for the collection of hypophysial portal blood from the cut pituitary stalk of rats. This method was used (Fink, Nallar & Worthington, 1967) to demonstrate the presence of LRF in portal blood obtained from pro-oestrous and hypophysectomized rats. The possibility that the activity of portal plasma was due to vasopressin or a non specific factor was largely excluded, but it was pointed out that a significant proportion of the activity of portal plasma from prooestrus rats could have been due to LH contained in back-flow blood from the pituitary sinusoids.


Anterior Pituitary Gland Portal Blood Systemic Plasma Median Eminence Oestrous Cycle 
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Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • G. Fink
    • 1
  1. 1.Department of Human AnatomyOxfordEngland

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