Studies on Luteinizing Hormone Releasing Factor (LRF) in Hypophysial Portal Blood of Rats
In 1966 Worthington described a method for the collection of hypophysial portal blood from the cut pituitary stalk of rats. This method was used (Fink, Nallar & Worthington, 1967) to demonstrate the presence of LRF in portal blood obtained from pro-oestrous and hypophysectomized rats. The possibility that the activity of portal plasma was due to vasopressin or a non specific factor was largely excluded, but it was pointed out that a significant proportion of the activity of portal plasma from prooestrus rats could have been due to LH contained in back-flow blood from the pituitary sinusoids.
KeywordsFiltration Tyrosine Fractionation Polypeptide Expense
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