Exercise in Elderly Cancer Survivors

Part of the Energy Balance and Cancer book series (EBAC, volume 6)


Aging is a universal experience that leads to declines in functional performance, sarcopenia, loss of flexibility, muscle weakness and decreased bone density. Cancer and its treatment accelerate these declines and lead to accelerated aging and disability. Cancer treatment can cause muscle wasting and declines in cardiopulmonary function that do not reverse in the recovery period following treatment. Many of these declines can be mitigated with exercise. A limited number of resistance exercise studies have been conducted focusing on improving body composition in elderly cancer survivors. These studies have demonstrated that resistance exercise is safe and improves muscle strength and cardiovascular function. Aerobic exercise studies are more numerous and also demonstrate the safety of exercise and the benefits on cardiopulmonary function, muscle strength, maintenance of body weight, body fat, balance, and bone density. Prevention of sarcopenia and muscle development in elderly cancer survivors should focus on increasing protein intake to approximately 40 g/day and include leucine. Being overweight at the time of diagnosis is associated with an increased overall and cancer-specific mortality for cancers of the breast, esophagus, colorectum, cervix, uterus, liver, gallbladder, stomach, pancreas, prostate, kidney, non-Hodgkin’s lymphoma and multiple myeloma, as well as all cancers combined. Weight gain, overweight and obesity following treatment is associated with greater risks for recurrence and cancer-related death. Given the growing body of evidence of the adverse effects of cancer treatment on body composition and the negative consequences for overall health and physical function, exercise and weight management should be a high priority for cancer survivors; especially for elderly cancer survivors who may already have multiple co-morbid conditions that may be improved with exercise.


Cancer Survivor Body Composition Breast Cancer Survivor Resistance Exercise Lean Body Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Abrahamson PE, Gammon MD, Lund MJ, Flagg EW, Porter PL, Stevens J, Swanson CA, Brinton LA, Eley JW, Coates RJ. (2006) General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiol Biomarkers Prev. 15(10):1871–1877Google Scholar
  2. 2.
    Agency for Healthcare Research and Quality (2004) Effectiveness of behavioral interventions to modify physical activity behaviors in general populations and cancer patients and survivors. U.S. Department of Health and Human Services, Rockville, MD, pp 107–111, AHRQ Publ. No. 04-E027-2Google Scholar
  3. 3.
    Baim S, Binkley N, Bilezikian JP, Kendler DL, Hans DB, Lewiecki EM et al (2008) Official positions of the international society for clinical densitometry and executive summary of the 2007 ISCD position development conference. J Clin Densitom 11:75–91PubMedCrossRefGoogle Scholar
  4. 4.
    Barrett SV, Paul J, Hay A, Vasey PA, Kaye SB, Glasspool RM, Scottish Gynaecological Cancer Trials Group (2008) Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial. Ann Oncol 19(5):898–902PubMedCrossRefGoogle Scholar
  5. 5.
    Becker S, Dossus L, Kaaks R (2009) Obesity related hyperinsulinaemia and hyperglycaemia and cancer development. Arch Physiol Biochem 115(2):86–96PubMedCrossRefGoogle Scholar
  6. 6.
    Breen L, Phillips SM (2011) Skeletal muscle protein metabolism in the elderly: interventions to counteract the ‘anabolic resistance’ of ageing. Nutr Metab (London) 5(8):68CrossRefGoogle Scholar
  7. 7.
    Brown JK, Byers T, Doyle C et al (2003) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 53:268–291PubMedCrossRefGoogle Scholar
  8. 8.
    Bruera E, Carraro S, Roca E, Barugel M, Chacon R (1986) Double-blind evaluation of the effects of mazindol on pain, depression, anxiety, appetite, and activity in terminal cancer patients. Cancer Treat Rep 70(2):295–298PubMedGoogle Scholar
  9. 9.
    Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625–1638PubMedCrossRefGoogle Scholar
  10. 10.
    Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579–591PubMedCrossRefGoogle Scholar
  11. 11.
    Caan B, Sternfeld B, Gunderson E, Coates A, Quesenberry C, Slattery ML (2005) Life after cancer epidemiology (LACE) study: a cohort of early stage breast cancer survivors (United States). Cancer Causes Control 16:545–556PubMedCrossRefGoogle Scholar
  12. 12.
    Caan BJ, Emond JA, Natarajan L et al (2006) Postdiagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat 99:47–57PubMedCrossRefGoogle Scholar
  13. 13.
    Caan BJ et al (2008) Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control 19:1319–1328PubMedCrossRefGoogle Scholar
  14. 14.
    Camoriano JK, Loprinzi CL, Ingle JN, Therneau TM, Krook JE, Veeder MH (1990) Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer. J Clin Oncol 8:1327–1334PubMedGoogle Scholar
  15. 15.
    Carmichael AR, Bates T (2004) Obesity and breast cancer: a review of the literature. Breast 13:85–92PubMedCrossRefGoogle Scholar
  16. 16.
    Chen H, Miller BA, Giovannucci E, Hayes RB (2003) Height and the survival of prostate cancer patients. Cancer Epidemiol Biomarkers Prev 12:215–218PubMedGoogle Scholar
  17. 17.
    Chen X, Lui W, Zheng W, Gu K, Matthews CE, Chen Z, Zheng Y, Shu XO (2011) Exercise after diagnosis of breast cancer in association with survival. Cancer Prev Res 4(9):1409–1418CrossRefGoogle Scholar
  18. 18.
    Chen Z, Wang Z, Lohman T, Heymsfield SB, Outwater E, Nicholas JS, Bassford T, LaCroix A, Sherrill D, Punyanitya M, Wu G, Going S (2007) Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women. J Nutr 137(12):2775–2780PubMedGoogle Scholar
  19. 19.
    Cheney CL, Mahloch J, Freeny P (1997) Computerized tomography assessment of women with weight changes associated with adjuvant treatment for breast cancer. Am J Clin Nutr 66(1):141–146PubMedGoogle Scholar
  20. 20.
    Chlebowski RT, Aiello E, McTiernan A (2002) Weight loss in breast cancer patient management. J Clin Oncol 20:1128–1143PubMedCrossRefGoogle Scholar
  21. 21.
    Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK et al (2006) Dietary fat reduction and breast cancer outcome: interim efficacy results from the women’s intervention nutrition study (WINS). J Natl Cancer Inst 98(24):1767–1776PubMedCrossRefGoogle Scholar
  22. 22.
    Coffer PJ (2009) When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction. Cell Res 19(7):797–799PubMedCrossRefGoogle Scholar
  23. 23.
    Cook Z, Kirk S, Lawrenson S, Sandford S (2005) Use of BMI in the assessment of undernutrition in older subjects: reflecting on practice. Proc Nutr Soc 64:313–317PubMedCrossRefGoogle Scholar
  24. 24.
    Courneya KS, Karvinen KH, Campbell KL et al (2005) Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol 97:422–430PubMedCrossRefGoogle Scholar
  25. 25.
    Courneya KS, Vallance JK, McNeely ML, Karvinen KH, Peddle CJ, Mackey JR (2004) Exercise issues in older cancer survivors. Crit Rev Oncol Hematol 51(3):249–261, ReviewPubMedCrossRefGoogle Scholar
  26. 26.
    Decastro GJ, McKiernan JM (2008) Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol Clin North Am 35(4):581–592, LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S (2008) Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. Exp Clin Endocrinol Diabetes 116(Suppl 1):S4–S6PubMedCrossRefGoogle Scholar
  27. 27.
    Daniell HW (2001) Osteoporosis due to androgen deprivation therapy in men with prostate cancer. Urology 58(2 Suppl 1):101–107PubMedCrossRefGoogle Scholar
  28. 28.
    de Azambuja E, McCaskill-Stevens W, Francis P, Quinaux E, Crown JP et al (2010) The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial. Breast Cancer Res Treat 119(1):145–153PubMedCrossRefGoogle Scholar
  29. 29.
    Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM (2005) Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol 23:5814–5830PubMedCrossRefGoogle Scholar
  30. 30.
    Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK (2001) Changes in weight, body composition, and factors influencing energy ­balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 19(9):2381–2389PubMedGoogle Scholar
  31. 31.
    Dignam JJ, Polite BN, Yothers G et al (2006) Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 98:1647–1654PubMedCrossRefGoogle Scholar
  32. 32.
    Dignam JJ, Wieand K, Johnson KA et al (2006) Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. Breast Cancer Res Treat 97:245–254PubMedCrossRefGoogle Scholar
  33. 33.
    Doyle C, Kushi LH, Byers T et al (2006) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 56:323–353PubMedCrossRefGoogle Scholar
  34. 34.
    Djuric Z, DiLaura NM, Jenkins I et al (2002) Combining weight-loss counseling with the eight watchers plan for obese breast cancer survivors. Obes Res 10:657–665PubMedCrossRefGoogle Scholar
  35. 35.
    Damauer JS, Stadler ME, Acharyya S, Baldwin A, Couch ME, Guttridge DC (2008) Chemotherapy-induced muscle wasting: association with NF-B and cancer cachexia. Basic Appl Myol 18(5):139–148Google Scholar
  36. 36.
    Efstathiou JA, Bae K, Shipley WU, Hanks GE, Pilepich MV, Sandler HM, Smith MR (2007) Obesity and mortality in men with locally advanced prostate cancer: analysis or RTOG 85-31. Cancer 110(12):2691–2699PubMedCrossRefGoogle Scholar
  37. 37.
    Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC (2010) Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med 170(19):1758–1764PubMedCrossRefGoogle Scholar
  38. 38.
    Enger SM, Greif JM, Polikoff J, Press M (2004) Body weight correlates with mortality in early stage breast cancer. Arch Surg 139:954–958, discussion 58–60PubMedCrossRefGoogle Scholar
  39. 39.
    Enger SM, Bernstein L (2004) Exercise activity, body size and premenopausal breast cancer survival. Br J Cancer 90:2138–2141PubMedGoogle Scholar
  40. 40.
    Freedland SJ, Aronson WJ, Kane CJ et al (2004) Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the shared equal access regional cancer hospital database study group. J Clin Oncol 22:446–453PubMedCrossRefGoogle Scholar
  41. 41.
    Flynn MA, Nolph GB, Baker AS, Martin WM, Krause G (1989) Total body potassium in aging humans: a longitudinal study. Am J Clin Nutr 50:713–717PubMedGoogle Scholar
  42. 42.
    Forbes GB (1976) The adult decline in lean body mass. Hum Biol 48:161–173, Google Scholar
  43. 43.
    Freedman RJ, Aziz N, Albanes D, Hartman T, Danforth D, Hill S, Sebring N, Reynolds JC, Yanovski JA (2004) Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab 89(5):2248–2253PubMedCrossRefGoogle Scholar
  44. 44.
    Galanis DJ, Kolonel LN, Lee J, Le Marchand L (1998) Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States. Cancer Causes Control 9:217PubMedCrossRefGoogle Scholar
  45. 45.
    Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y (2000) Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 72:694–701PubMedGoogle Scholar
  46. 46.
    Gallagher D, Ruts E, Visser M, Heshka S, Baumgartner RN, Wang J et al (2000) Weight stability masks sarcopenia in elderly men and women. Am J Physiol Endocrinol Metab 279:366–375Google Scholar
  47. 47.
    Gallagher D, Visser M, De Meersman RE et al (1997) Appendicular skeletal muscle mass: effects of age, gender, and ethnicity. J Appl Physiol 83:229–239, Google Scholar
  48. 48.
    Galvão D, Spry N, Taaffe D, Newton R, Stanley J, Shannon T et al (2008) Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer. BJU Int 102:44–47PubMedCrossRefGoogle Scholar
  49. 49.
    Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S, Surmacz E (2006) Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12(5):1447–1453PubMedCrossRefGoogle Scholar
  50. 50.
    Godsland IF (2009) Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci (London) 118(5):315–332CrossRefGoogle Scholar
  51. 51.
    Goodwin P, Esplen MJ, Butler K et al (1998) Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat 48:53–64PubMedCrossRefGoogle Scholar
  52. 52.
    Greenman CG, Jagielski CH, Griggs JJ (2008) Breast cancer adjuvant chemotherapy dosing in obese patients: dissemination of information from clinical trials to clinical practice. Cancer 112(10):2159–2165PubMedCrossRefGoogle Scholar
  53. 53.
    Gregg EW, Pereira MA, Caspersen CJ (2000) Physical activity, falls, and fractures among older adults: a review of the epidemiologic evidence. J Am Geriatr Soc 48(8):883–893PubMedGoogle Scholar
  54. 54.
    Grunfeld E, Dhesy-Thind S, Levine M (2005) Clinical practice guidelines for the care and treatment of breast cancer: follow-up after treatment for breast cancer (summary of the 2005 update). CMAJ 172:1319–1320PubMedCrossRefGoogle Scholar
  55. 55.
    Hansen PA, Dechet CB, Porucznik CA, LaStayo PC (2009) Comparing eccentric resistance exercise in prostate cancer survivors on and off hormone therapy: a pilot study. Phys Med Rehab 1(11):1019–1024Google Scholar
  56. 56.
    Harvie MN, Campbell IT, Baildam A, Howell A (2004) Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat 83(3):201–210PubMedCrossRefGoogle Scholar
  57. 57.
    Harvie MN, Howell A, Thatcher N, Baildam A, Campbell I (2005) Energy balance in patients with advanced NSCLC, metastatic melanoma and metastatic breast cancer receiving chemotherapy – a longitudinal study. Br J Cancer 92:673–680PubMedCrossRefGoogle Scholar
  58. 58.
    Haseen F, Murray LJ, Cardwell CR, O’Sullivan JM, Cantwell MM (2010) The effect of androgen deprivation therapy on body composition in men with prostate cancer: systematic review and meta-analysis. J Cancer Surviv 4(2):128–139PubMedCrossRefGoogle Scholar
  59. 59.
    Harris SR, Niesen-Vertommen SL (2000) Challenging the myth of exercise-induced lymphedema following breast cancer: a series of case reports. J Surg Oncol 74:95–98, discussion 98–99PubMedCrossRefGoogle Scholar
  60. 60.
    Hewitt M, Greenfield S, Stovall EL (2005) Institute of medicine and national research council: from cancer patient to cancer survivors: lost in transition. National Academies Press, Washington, DCGoogle Scholar
  61. 61.
    Holloszy JO, Booth FW (1976) Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol 38:273–291PubMedCrossRefGoogle Scholar
  62. 62.
    Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293:2479–2486PubMedCrossRefGoogle Scholar
  63. 63.
    Honda J, Kanematsu NM, Takahashi M, Nagao T, Tangoku A, Sasa A (2011) Joint symptoms, aromatase inhibitor-related adverse reactions, Are indirectly associated with decreased serum estradiol. Int J Surg Oncol 2011:7, Article ID 951260Google Scholar
  64. 64.
    Hurley BF, Roth SM (2000) Strength training in the elderly: effects on risk factors for age-related diseases. Sports Med 30(4):249–268PubMedCrossRefGoogle Scholar
  65. 65.
    Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard-Barbash R (2003) Physical activity levels before and after a diagnosis of breast carcinoma: the health, eating, activity, and lifestyle (HEAL) study. Cancer 97(7):1746–1757PubMedCrossRefGoogle Scholar
  66. 66.
    Irwin ML, Mayne ST (2008) Impact of nutrition and exercise on cancer survival. Cancer J 14(6):435–441PubMedCrossRefGoogle Scholar
  67. 67.
    Irwin ML, McTiernan A, Manson JE, Thomson CA, Sternfeld B, Stefanick ML, Wactawski-Wende J, Craft L, Lane D, Martin LW, Chlebowski R (2011) Physical activity and survival in postmenopausal women with breast cancer: results from the women’s health initiative. Cancer Prev Res (Philadelphia) 4(4):522–529CrossRefGoogle Scholar
  68. 68.
    Irwin ML, Yasui Y, Ulrich CM et al (2003) Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA 289:323–330PubMedCrossRefGoogle Scholar
  69. 69.
    Jiang W, Zhu Z, Thompson HJ, Jiang W, Zhu Z, Thompson HJ (2009) Effects of physical activity and restricted energy intake on chemically induced mammary carcinogenesis. Cancer Prevent Res 2(4):338–344CrossRefGoogle Scholar
  70. 70.
    Jones L, Demark-Wahnefried W (2007) Recommendations for health behavior and wellness following primary treatment for cancer. National Academies Press, Washington, DCGoogle Scholar
  71. 71.
    Kenfield SA, Stampfer MJ, Giovannucci E, Chan JM (2011) Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study. J Clin Oncol 29(6):726–732, Epub 2011 Jan 4PubMedCrossRefGoogle Scholar
  72. 72.
    Kim DJ, Gallagher RP, Hislop TG et al (2000) Premorbid diet in relation to survival from prostate cancer (Canada). Cancer Causes Control 11:65–77PubMedCrossRefGoogle Scholar
  73. 73.
    Kroenke CH, Chen WY, Rosner B, Holmes MD (2005) Weight, weight gain and survival after breast cancer. J Clin Oncol 23:1370PubMedCrossRefGoogle Scholar
  74. 74.
    Kutynec CL, McCargar L, Barr SI, Hislop TG (1999) Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc 99(10):1222–1227PubMedCrossRefGoogle Scholar
  75. 75.
    Kyle UG, Genton L, Hans D, Karsegard VL, Michel JP, Slosman DO, Pichard C (2001) Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-sectional differences in 60-year-old persons. J Am Geriatr Soc 49:1633–1640PubMedCrossRefGoogle Scholar
  76. 76.
    Kyle UG, Genton L, Hans D, Karsegard L, Slosman DO, Pichard C (2001) Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. Eur J Clin Nutr 55:663–672PubMedCrossRefGoogle Scholar
  77. 77.
    LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S (2008) Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. Exp Clin Endocrinol Diabetes 116(Suppl 1):S4–S6PubMedCrossRefGoogle Scholar
  78. 78.
    LeStayo PC, Marcus RL, Dibble LE, Smith SB, Beck SL (2011) Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility – an exploratory pilot study. BMC Geriatr 11:5CrossRefGoogle Scholar
  79. 79.
    Levy M, Perera S, van Londen G, Nelson J, Clay C, Greenspan S (2008) Physical function changes in prostate cancer patients on androgen deprivation therapy: a 2-year prospective study. Urology 71:735–739PubMedCrossRefGoogle Scholar
  80. 80.
    Loi S, Milne RL, Friedlander ML, McCredie MR, Giles GG, Hopper JL, Phillips KA. (2005) Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev. 14(7):1686–1691.PubMedCrossRefGoogle Scholar
  81. 81.
    Maccormick RE (2006) Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty? Med Hypotheses 67:212–215PubMedCrossRefGoogle Scholar
  82. 82.
    Maeso Fortuny MdC, Brito Diaz B, de Cabrera Leon A (2006) Leptin, estrogens and cancer. Mini Rev Med Chem 6(8):897–907PubMedCrossRefGoogle Scholar
  83. 83.
    McCargar L (2007) New insights into body composition and health through imaging analysis. Can J Diet Pract Res 68:160–165PubMedCrossRefGoogle Scholar
  84. 84.
    McTiernan A (2005) Obesity and cancer: the risks, science, and potential management strategies. Oncology (Williston Park) 19:871–881, discussion 881–882, 885–886Google Scholar
  85. 85.
    McTiernan A, Irwin M, VonGruenigen V (2010) Weight, physical activity, diet and prognosis in breast and gynecologic cancer. J Clin Oncol 28(26):4047–4080CrossRefGoogle Scholar
  86. 86.
    McTiernan A, Ulrich CM, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9:487–509PubMedCrossRefGoogle Scholar
  87. 87.
    Meyer F, Bairati I, Shadmani R et al (1999) Dietary fat and prostate cancer survival. Cancer Causes Control 10:245–251PubMedCrossRefGoogle Scholar
  88. 88.
    Meyerhardt JA, Ma J, Courneya KS (2010) Energetics in colorectal and prostate cancer. J Clin Oncol 28(26):4066–4073PubMedCrossRefGoogle Scholar
  89. 89.
    Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS, Cancer and Leukemia Group B 89803 (2008) Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from cancer and leukemia group B 89803. J Clin Oncol 26(25):4109–4115PubMedCrossRefGoogle Scholar
  90. 90.
    National Institutes of Health (2000) The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. National Heart, Lungs, and Blood Institute, Bethesda, MDGoogle Scholar
  91. 91.
    Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA (2009) Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality. Cancer Epidemiol Biomarkers Prev 18(5):1403–1409, Epub 2009 Apr 14PubMedCrossRefGoogle Scholar
  92. 92.
    Nishiyama T, Ishizaki F, Anraku T, Shimura H, Takahashi K (2005) The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. J Clin Endocrinol Metab 90:657–660PubMedCrossRefGoogle Scholar
  93. 93.
    Novak LP (1972) Aging, total body potassium, fat-free mass, and cell mass in men and females between 18 and 85 years. J Gerontol 27:438–443, Google Scholar
  94. 94.
    Orr R, Raymond J (2008) Fiatarone Singh M. Efficacy of progressive resistance training on balance performance in older adults : a systematic review of randomized controlled trials. Sports Med. 38(4):317–43. ReviewPubMedCrossRefGoogle Scholar
  95. 95.
    Protani M, Coory M, Martin JH (2010) Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat 123(3):627–635PubMedCrossRefGoogle Scholar
  96. 96.
    Patterson RE, Cadmus LA, Emond JA, Pierce JP (2010) Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature. Maturitas 66(1):5–15PubMedCrossRefGoogle Scholar
  97. 97.
    Peterson MD, Sen A, Gordon PM (2011) Body mass in aging adults: a meta-analysis. Med Sci Sports Exerc 43(2):249–258PubMedCrossRefGoogle Scholar
  98. 98.
    Pollack LA, Rowland JH, Crammer C, Stefanek M (2009) Introduction: charting the landscape of cancer survivors’ health-related outcomes and care. Cancer. 15;115(18) :4265–4269.PubMedCrossRefGoogle Scholar
  99. 99.
    Raguso CA, Kyle U, Kossovsky MP, Roynette C, Paoloni-Giacobino A, Hans D et al (2006) A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise. Clin Nutr 25:573–580PubMedCrossRefGoogle Scholar
  100. 100.
    Ray A, Cleary MP (2010) Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opin Ther Targets 14(4):443–451PubMedCrossRefGoogle Scholar
  101. 101.
    Reis C, Liberman S, Pompeo AC, Srougi M, Halpern A, Jacob Filho W (2009) Body composition alterarions, energy expenditure and fat oxidation in elderly males suffering from prostate cancer, pre and post orchiectomy. Clinics (Sao Paulo) 64(8):781–784CrossRefGoogle Scholar
  102. 102.
    Reeves KW, Faulkner K, Modugno F et al (2007) Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures. Cancer Epidemiol Biomarkers Prev 16:1468–1473PubMedCrossRefGoogle Scholar
  103. 103.
    Robertson FM, Bondy M, Yang W, Yamauchi H, Wiggins S, Kamrudin S, Krishnamurthy S, Le-Petross H, Bidaut L, Player AN, Barsky SH, Woodward WA, Buchholz T, Lucci A, Ueno NT, Cristofanilli M (2010) Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin 60(6):351–375PubMedCrossRefGoogle Scholar
  104. 104.
    Rock CL, Demark-Wahnefried W (2002) Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J Clin Oncol 20:3302–3316PubMedCrossRefGoogle Scholar
  105. 105.
    Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, Bandera EV, Hamilton KK, Grant B, McCullough M, Byers T, Gansler T. (2012) Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 62(4):242–74. doi: 10.3322/caac.21142. Epub 2012 Apr 26PubMedCrossRefGoogle Scholar
  106. 106.
    Rolls BJ, Drewnowski A, Ledikwe JH (2005) Changing the energy density of the diet as a strategy for weight management. J Am Diet Assoc 105:S98–S103PubMedCrossRefGoogle Scholar
  107. 107.
    Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J et al (2008) Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes 32:959–966CrossRefGoogle Scholar
  108. 108.
    Rooyackers OE, Adey DB, Ades PA, Nair KS (1996) Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 93:15364–15369PubMedCrossRefGoogle Scholar
  109. 109.
    Rose DP, Komninou D, Stephenson GD (2004) Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 5:153–165PubMedCrossRefGoogle Scholar
  110. 110.
    Siegel EM, Ulrich CM, Poole EM, Holmes RS, Jacobsen PB, Shibata D (2010) The effects of obesity and obesity-related conditions on colorectal cancer prognosis. Cancer Control 17(1):52–57PubMedGoogle Scholar
  111. 111.
    Schmitz KH, Ahmed RL, Hannan PJ, Yee D (2005) Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol Biomarkers Prev 14:1672–1680PubMedCrossRefGoogle Scholar
  112. 112.
    Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42(7):1409–1426PubMedCrossRefGoogle Scholar
  113. 113.
    Schwartz AL (2009) Fatigue in long-term cancer survivors. Oncology (Williston Park) 23(8 Suppl):27, 33–34Google Scholar
  114. 114.
    Schwartz AL (2000) Exercise and weight gain in breast cancer patients receiving chemotherapy. Cancer Pract 8(5):231–237PubMedCrossRefGoogle Scholar
  115. 115.
    Schwartz AL, Winters-Stone K (2009) Effects of a 12-month randomized controlled trial of aerobic or resistance exercise during and following cancer treatment in women. Phys Sports Med 37(3):62–67CrossRefGoogle Scholar
  116. 116.
    Smith MR, Finkelstein JS, McGovern FJ, Zietman AL, Fallon MA, Schoenfeld DA et al (2002) Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 87:599–603PubMedCrossRefGoogle Scholar
  117. 117.
    Smith JC, Bennett S, Evans LM, Kynaston HG, Parmar M, Mason MD et al (2001) The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. J Clin Endocrinol Metab 86:4261–4267PubMedCrossRefGoogle Scholar
  118. 118.
    Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv 4:87–100PubMedCrossRefGoogle Scholar
  119. 119.
    Suh TT, Lyles KW (2003) Osteoporosis considerations in the frail elderly. Curr Opin Rheumatol 15(4):481–486PubMedCrossRefGoogle Scholar
  120. 120.
    Strasser B, Schobersberger W (2011) Evidence for resistance training as a treatment therapy in obesity. J Obes 2011:1–7CrossRefGoogle Scholar
  121. 121.
    St-Onge MP (2005) Relationship between body composition changes and changes in physical function and metabolic risk factors in aging. Curr Opin Clin Nutr Metab Care 8:523–528PubMedGoogle Scholar
  122. 122.
    Stephenson GD, Rose DP (2003) Breast cancer and obesity: an update. Nutr Cancer 45:1–16PubMedCrossRefGoogle Scholar
  123. 123.
    Tao MH, Shu XO, Ruan ZX et al (2006) Association of overweight with breast cancer survival. Am J Epidemiol 163:101–107PubMedCrossRefGoogle Scholar
  124. 124.
    Thivat E, Thérondel S, Lapirot O, Abrial C, Gimbergues P, Gadéa E, Planchat E, Kwiatkowski F, Mouret-Reynier MA, Chollet P, Durando X (2010) Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer 10:648PubMedCrossRefGoogle Scholar
  125. 125.
    Trappe T, Williams R, Carrithers J, Raue U, Esmarck B, Kjaer M, Hickner R (2004) Influence of age and resistance exercise on human skeletal muscle proteolysis: a microdialysis approach. J Physiol 554:803–813PubMedCrossRefGoogle Scholar
  126. 126.
    Twiss JJ, Waltman NL, Berg K, Ott CD, Gross GJ, Lindsey AM (2009) An exercise intervention for breast cancer survivors with bone loss. J Nurs Scholarsh 41:20–27PubMedCrossRefGoogle Scholar
  127. 127.
    van Londen G, Matthew L, Perera S, Nelson J, Greenspan S (2008) Body composition changes during androgen deprivation therapy for prostate cancer: a 2-year prospective study. Crit Rev Oncol Hematol 68:172–177PubMedCrossRefGoogle Scholar
  128. 128.
    Vance V, Mourtzakis M, McCargar L, Hanning R (2011) Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev 12(4):282–294PubMedCrossRefGoogle Scholar
  129. 129.
    Vanio H, Bianchini F (2002) IARC handbooks of cancer prevention, vol 6, Weight Control and Physical Activity. International Agency for Research on Cancer, Lyon, FranceGoogle Scholar
  130. 130.
    Vona-Davis L, Rose DP (2009) Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev 20(3):193–201PubMedCrossRefGoogle Scholar
  131. 131.
    Vrieling A, Kampman E (2010) The role of body mass index, physical activity, and diet in colorectal cancer recurrence and survival: a review of the literature. Am J Clin Nutr 92(3):471–490PubMedGoogle Scholar
  132. 132.
    Winters-Stone KM, Dobek J, Bennett JA, Nail LM, Leo MC, Schwartz A (2012) The effect of resistance training on muscle strength and physical function in older, postmenopausal breast cancer survivors: a randomized controlled trial. J Cancer Surviv 6(2):189–199PubMedCrossRefGoogle Scholar
  133. 133.
    Winters-Stone K, Dobek J, Nail L, Bennett JA, Naik A, Schwartz A (2011) Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 27(2):447–456CrossRefGoogle Scholar
  134. 134.
    Winters-Stone KM, Nail L, Bennett JA, Schwartz A (2009) Bone health and falls: fracture risk in breast cancer survivors with chemotherapy-induced amenorrhea. Oncol Nurs Forum 36(3):315–325. doi: 412350H1L4266941 [pii]PubMedCrossRefGoogle Scholar
  135. 135.
    Winters-Stone, K, Michael, L, & Schwartz, A.L. Exercise effects on hip bone mineral density in older, post-menopausal breast cancer survivors are age dependent. Archives of Osteoporosis, 2012 DOI 10.1007/s11657-012-0071-6Google Scholar
  136. 136.
    Winters-Stone K, Torgrimson B, Horak F, Eisner A, Leo M, Nail L, Chui S, Luoh S-W (2011) Identifying risk factors for falls in postmenopausal breast cancer survivors: a multidisciplinary approach. Arch Phys Med Rehabil 92(4):646–652, Epub 2011 Mar 2PubMedCrossRefGoogle Scholar
  137. 137.
    Wolfe RR, Miller SL, Miller KB. Optimal protein intake in the elderly. Clin Nutr. 2008 Oct;27(5):675–84. Epub 2008 Sep 25CrossRefGoogle Scholar
  138. 138.
    Wolfson L, Judge J, Whipple R, King M (1995) Strength is a major factor in balance, gait, and the occurrence of falls. J Gerontol A Biol Sci Med Sci 50 (Spec No.):64–67Google Scholar
  139. 139.
    Work Health Organization (2004) Global strategy on diet, physical activity, and health. Work Health Organization, GenevaGoogle Scholar
  140. 140.
    de Waard F, Ramlau R, Mulders Y, de Vries T, van Waveren S (1993) A feasibility study on weight reduction in obese postmenopausal breast cancer patients. Eur J Cancer Prev 2:233–238PubMedCrossRefGoogle Scholar
  141. 141.
    Welle S, Thornton C, Jozefowicz R, Statt M (1993) Myofibrillar protein synthesis in young and old men. Am J Physiol 264:E693–E698PubMedGoogle Scholar
  142. 142.
    Wright ME, Chang S-C, Schatzkin A et al (2007) Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer 109:675–684PubMedCrossRefGoogle Scholar
  143. 143.
    Yarasheski KE, Zachwieja JJ, Bier DM (1993) Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol 265:E210–E214PubMedGoogle Scholar
  144. 145.
    Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, Bandera EV, Hamilton KK, Grant B, McCullough M, Byers T, Gansler T. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012 Jul;62(4):242–74. doi: 10.3322/caac.21142. Epub 2012 Apr 26.PubMedGoogle Scholar
  145. 149.
    Loi S, Milne RL, Friedlander ML, McCredie MR, Giles GG, Hopper JL, Phillips KA. Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1686–91.PubMedGoogle Scholar
  146. 150.
    Smith MR, Finkelstein JS, McGovern FJ, Zietman AL, Fallon MA, Schoenfeld DA, Kantoff PW. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2002 Feb;87(2):599–603.PubMedGoogle Scholar
  147. 151.
    Orr R, Raymond J, Fiatarone Singh M. Efficacy of progressive resistance training on balance performance in older adults : a systematic review of randomized controlled trials. Sports Med. 2008;38(4):317–43. Review.PubMedGoogle Scholar
  148. 152.
    Camoriano JK, Loprinzi CL, Ingle JN, Therneau TM, Krook JE, Veeder MH. Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer. J Clin Oncol. 1990 Aug;8(8):1327–34.PubMedGoogle Scholar

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Idaho State UniversityPocatelloUSA
  2. 2.University of WashingtonSeattleUSA
  3. 3.Oregon Health and Sciences UniversityPortlandUSA

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