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Interactions Between HIV-1 and Innate Immunity in Dendritic Cells

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Book cover HIV Interactions with Dendritic Cells

Part of the book series: Advances in Experimental Medicine and Biology ((volume 762))

Abstract

Dendritic cells couple pathogen sensing with induction of innate and adaptive immune responses. Pathogen sensing in dendritic cells relies on interactions between molecular patterns of the pathogens and germline-encoded, also referred to as innate, receptors. In this chapter, we analyze some of the interactions between HIV-1 and the innate immune system in dendritic cells. The HIV-1 replication cycle is constituted by an extracellular and an intracellular phase. The two phases of the cycle provide distinct opportunities for interactions with cell-extrinsic and cell-intrinsic mechanisms in dendritic cells. According to the types of dendritic cells, the mechanisms of innate interactions between dendritic cells and HIV-1 lead to specific responses. These innate interactions may contribute to influencing and shaping the adaptive immune response against the virus.

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Acknowledgements

We apologize to the authors and colleagues whose work was not cited. We thank Philippe Benaroch, Vassili Soumelis, Xavier Lahaye, and Takeshi Satoh for critical reading of the manuscript.

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  1. Department of Immunity and Cancer, Institut Curie-INSERM U932, 12 rue Lhomond, Paris, 75011, France

    Aymeric Silvin (Doctoral Student) & Nicolas Manel Ph.D.

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  1. Aymeric Silvin
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  2. Nicolas Manel Ph.D.
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Correspondence to Nicolas Manel Ph.D. .

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  1. , Center for Retrovirus Research, The Ohio State University, 466 VMAB, 1900 Coffey Road, Columbus, 43210, Ohio, USA

    Li Wu

  2. , Department of Virology, Institut Pasteur, 28 rue du Dr Roux, Paris, 75724, France

    Olivier Schwartz

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Silvin, A., Manel, N. (2012). Interactions Between HIV-1 and Innate Immunity in Dendritic Cells. In: Wu, L., Schwartz, O. (eds) HIV Interactions with Dendritic Cells. Advances in Experimental Medicine and Biology, vol 762. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4433-6_7

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