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Mechanics of Biological Systems and Materials, Volume 5 pp 197–205Cite as

Developing a Microloading Platform for Applications in Mechanotransduction Research

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Abstract

Bone cell mechanotransduction involves the process by which bone cells sense and coordinate their activity in response to mechanical loading. Classic mechanotransduction models include the parallel plate flow and cone viscometer systems. These systems apply fluid flow to bone cells to study the effects of fluid shear on cellular activity. In this study a microactuated loading device to subject bone cells to a complex state of deformation utilizing a deformable membrane was developed. To model the loading profile, finite element analysis was utilized with material properties of polydimethylsiloxane (PDMS) determined from mechanical testing to model a cell substrate and loading platen to apply accurate, reproducible and physiologically appropriate loading.

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Acknowledgements

Partial support for this work was provided by an NSF CAREER Award and an NIH NIDCR AREA (R15) Award.

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Authors and Affiliations

  1. Department of Biomedical Engineering, The University of Akron, Akron, OH, 44325, USA

    Karan S. Shah, Spencer L. York & Marnie M. Saunders

  2. Center for Biomedical Engineering, University of Louisville, Louisville, KY, 40208, USA

    Palaniappan Sethu

Authors
  1. Karan S. Shah
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  2. Spencer L. York
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  3. Palaniappan Sethu
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  4. Marnie M. Saunders
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Corresponding author

Correspondence to Karan S. Shah .

Editor information

Editors and Affiliations

  1. Auburn University, Alabama, Auburn, 36849-5341, USA

    Barton C. Prorok

  2. McGill University, Montreal, H4B 2R3, Canada

    François Barthelat

  3. State University of New York, State University of New York, Stony Brook, 11794, USA

    Chad S. Korach

  4. Rice University, Houston, 77251-1892, USA

    K. Jane Grande-Allen

  5. Auburn University, Auburn, 36849-5127, USA

    Elizabeth Lipke

  6. University of Connecticut, Storrs, 06269-3088, USA

    George Lykofatitits

  7. Purdue University, West Lafayette, 47907-2051, USA

    Pablo Zavattieri

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© 2013 The Society for Experimental Mechanics, Inc.

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Cite this paper

Shah, K.S., York, S.L., Sethu, P., Saunders, M.M. (2013). Developing a Microloading Platform for Applications in Mechanotransduction Research. In: Prorok, B., et al. Mechanics of Biological Systems and Materials, Volume 5. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4427-5_28

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  • DOI: https://doi.org/10.1007/978-1-4614-4427-5_28

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4426-8

  • Online ISBN: 978-1-4614-4427-5

  • eBook Packages: EngineeringEngineering (R0)

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