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Biologically Responsive Biomaterials for Tissue Engineering pp 1–16Cite as

Scaffold Design for Bone Tissue Engineering: From Micrometric to Nanometric Level

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Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 1))

Abstract

Porous biodegradable polymeric scaffolds are essential for tissue ­engineering application since they should provide the adequate three-dimensional structure for cellular attachment and tissue development. In this context, recent paradigm moves towards new fabrication techniques able to develop micro- and nano-structured platforms which assure an optimal balance in terms of cell ­recognition, mass transport properties, and mechanical response to reproduce the morphological and functional features of natural tissues at the microscopic and nanoscopic level. Here, a large variety of technologies has been proposed to develop tailor-made platforms with micro/nanoscale architecture and chemical composition suitable for regenerating natural bony extracellular matrix (bECM).

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Acknowledgments

This study was supported by the Italian Research Network “TISSUENET” n. RBPR05RSM2 and by IP STEPS EC FP6-500465.

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Authors and Affiliations

  1. Institute of Composite and Biomedical Materials, National Research Council, P.le Tecchio 80, Naples, 80125, Italy

    Vincenzo Guarino, Maria Grazia Raucci, Marco A. Alvarez-Perez, Valentina Cirillo, Alfredo Ronca & Luigi Ambrosio

Authors
  1. Vincenzo Guarino
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  2. Maria Grazia Raucci
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  3. Marco A. Alvarez-Perez
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  4. Valentina Cirillo
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  5. Alfredo Ronca
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  6. Luigi Ambrosio
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Corresponding author

Correspondence to Vincenzo Guarino .

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Editors and Affiliations

  1. , Faculty Materials Science and, University Politehnica of Bucharest, Spl. Independentei, Sect. 6 313, Bucharest, 060042, Romania

    Iulian Antoniac

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Guarino, V., Raucci, M.G., Alvarez-Perez, M.A., Cirillo, V., Ronca, A., Ambrosio, L. (2013). Scaffold Design for Bone Tissue Engineering: From Micrometric to Nanometric Level. In: Antoniac, I. (eds) Biologically Responsive Biomaterials for Tissue Engineering. Springer Series in Biomaterials Science and Engineering, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4328-5_1

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