Onion

  • Denys J. Charles
Chapter

Abstract

Onion is a perennial or biennial herb with strong antioxidant properties and this correlates well with the total phenolic and flavonoid content. This chapter describes the botany, history, producing regions, flavor and aroma, parts used, and active constituents. The chapter also highlights the uses of onion in different recipes around the world. It is an important ingredient in all cuisines worldwide. Onion has been reported to have anticancer, antimicrobial, antibacterial, hypoglycemic, antiplatelet aggregation, antiasthmatic, antiallergic, lipid- and blood pressure-lowering, and antioxidant properties. Finally the medicinal uses, functional properties, and antioxidant properties of onion are discussed in great detail.

Keywords

Cholesterol Adduct Diesel Nitrite Disulfide 

References

  1. Al-Fayez M, Cai H, Tunstall R, Steward WP, Gescher AJ (2006) Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin. Cancer Chemother Pharmacol 58(6):816–825CrossRefGoogle Scholar
  2. Arung ET, Wijaya Kusuma I, Shimizu K, Kondo R (2011a) Tyrosinase inhibitory effect of quercetin 4′-O-β-D-glucopyranoside from dried skin of red onion (Allium cepa). Nat Prod Res 25(3):256–263CrossRefGoogle Scholar
  3. Arung ET, Furuta S, Ishikawa H, Tanaka H, Shimizu K, Kondo R (2011b) Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3′-O-beta-D-glucoside isolated from Allium cepa. Z Naturforsch C 66(5–6):209–214CrossRefGoogle Scholar
  4. Augusti KT (1990) Therapeutic and medicinal values of onion and garlic. In: Brewster JL, Robinowitch HD (eds) Onions and allied crops, vol III. CRC, Boca Raton, FLGoogle Scholar
  5. Azuma K, Ippoushi K, Terao J (2010) Evaluation of tolerable levels of dietary quercetin for exerting its antioxidative effect in high cholesterol-fed rats. Food Chem Toxicol 48(4):1117–1122CrossRefGoogle Scholar
  6. Banerjee SK, Maulik M, Mancahanda SC, Dinda AK, Gupta SK, Maulik SK (2002) Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. Life Sci 70(13):1509–1518CrossRefGoogle Scholar
  7. Benitez V, Molla E, Martin-Cabrejas MA, Aguilera Y, Lopez-Andreu FJ, Cools K, Terry LA, Esteban RM (2011) Characterization of industrial onion wastes (Allium cepa L.): dietary fibre and bioactive compounds. Plant Foods Hum Nutr 66(1):48–57CrossRefGoogle Scholar
  8. Bhanot A, Shri R (2010) A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice. Pharmacognosy Res 2(6):374–384CrossRefGoogle Scholar
  9. Blomhoff R (2005) Dietary antioxidants and cardiovascular disease. Curr Opin Lipidol 16(1):47–54CrossRefGoogle Scholar
  10. Bose C, Guo J, Zimniak L, Srivastava SK, Singh SP, Zimniak P, Singh SV (2002) Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic. Carcinogenesis 23(10):1661–1665CrossRefGoogle Scholar
  11. Boyer J, Brown D, Liu RH (2005) In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Nutr J 4:1CrossRefGoogle Scholar
  12. Cao G, Sofic E, Prior RI (1996) Antioxidant capacity of tea and common vegetables. J Agric Food Chem 44:4326–4331CrossRefGoogle Scholar
  13. Cazzola R, Camerotto C, Cestaro B (2011) Anti-oxidant, anti-glycant, and inhibitory activity against α-amylase and α-glucosidase of selected spices and culinary herbs. Int J Food Sci Nutr 62(2):175–184CrossRefGoogle Scholar
  14. Chang HS, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O (2010) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. Nutr Res 30(6):435–440CrossRefGoogle Scholar
  15. Chevallier A (1996) The encyclopaedia of medicinal plants. Dorling Kindersley, LondonGoogle Scholar
  16. Cho JW, Cho SY, Lee SR, Lee KS (2010) Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. Int J Mol Med 25(3):347–352CrossRefGoogle Scholar
  17. Chun HS, Kim HJ, Choi EH (2001) Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells. Biosci Biotechnol Biochem 65(10):2205–2212CrossRefGoogle Scholar
  18. Colli JL, Amling CL (2009) Chemoprevention of prostate cancer: what can be recommended to patients? Curr Urol Rep 10(3):165–171CrossRefGoogle Scholar
  19. Dini I, Tenore GC, Dini A (2008) S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds. J Nat Prod 71(12):2036–2037CrossRefGoogle Scholar
  20. Dorant E, van den Brandt PA, Goldbohm RA, Sturmans F (1996) Consumption of onions and a reduced risk of stomach carcinoma. Gastroenterology 110(1):12–20CrossRefGoogle Scholar
  21. Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T (2007) Quercetin reduces blood pressure in hypertensive subjects. J Nutr 137(11):2405–2411Google Scholar
  22. Eguchi A, Murakami A, Ohigashi H (2005) Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells. Free Radic Res 39(12):1367–1375CrossRefGoogle Scholar
  23. El-Demerdash FM, Yousef MI, El-Naga NI (2005) Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 43(1):57–63CrossRefGoogle Scholar
  24. Galluzzo P, Martini C, Bulzomi P, Leone S, Bolli A, Pallottini V, Marino M (2009) Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol Nutr Food Res 53(6):699–708CrossRefGoogle Scholar
  25. Gao CM, Takezaki T, Ding JH, Li MS, Tajima K (1999) Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. Jpn J Cancer Res 90(6):614–621CrossRefGoogle Scholar
  26. Gazzani G, Papetti A, Massolini G, Daglia M (1998) Anti- and pro-oxidant activity of water soluble components of some common diet vegetables and the effect of thermal treatment. J Agric Food Chem 46:4118–4122CrossRefGoogle Scholar
  27. Geoghegan F, Wong RW, Rabie AB (2010) Inhibitory effect of quercetin on periodontal pathogens in vitro. Phytother Res 24(6):817–820Google Scholar
  28. Gorinstein S, Leontowicz H, Leontowicz M, Namiesnik J, Najman K, Drzewiecki J, Cvikrová M, Martincová O, Katrich E, Trakhtenberg S (2008) Comparison of the main bioactive compounds and antioxidant activities in garlic and white and red onions after treatment protocols. J Agric Food Chem 56(12):4418–4426CrossRefGoogle Scholar
  29. Gorinstein S, Leontowicz H, Leontowicz M, Jastrzebski Z, Najman K, Tashma Z, Katrich E, Heo BG, Cho JY, Park YJ, Trakhtenberg S (2010) The influence of raw and processed garlic and onions on plasma classical and non-classical atherosclerosis indices: investigations in vitro and in vivo. Phytother Res 24(5):706–714Google Scholar
  30. Gorinstein S, Leontowicz H, Leontowicz M, Najman K, Bielecki W, Ham KS, Kang SG, Paredes-Lopez O, Martinez-Ayala AL, Trakhtenberg S (2011) Aorta and liver changes in rats fed cholesterol-containing and raw vegetable-supplemented diets: experiments in vitro and in vivo. J Agric Food Chem 59(13):7441–7451CrossRefGoogle Scholar
  31. Guruvayoorappan C, Kuttan G (2007) Rutin inhibits nitric oxide and tumor necrosis factor-alpha production in lipopolysaccharide and concanavalin-a stimulated macrophages. Drug Metabol Drug Interact 22(4):263–278CrossRefGoogle Scholar
  32. Haidari F, Rashidi MR, Keshavarz SA, Mahboob SA, Eshraghian MR, Shahi MM (2008) Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. Pak J Biol Sci 11(14):1779–1784CrossRefGoogle Scholar
  33. Haleagrahara N, Radhakrishnan A, Lee N, Kumar P (2009) Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats. Eur J Pharmacol 621(1–3):46–52CrossRefGoogle Scholar
  34. Huang Z, Wang B, Eaves DH, Shikany JM, Pace RD (2009) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for Cardiovascular Equality Project. Int J Food Sci Nutr 60(2):100–108CrossRefGoogle Scholar
  35. Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM (2004) Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J Thromb Haemost 2(12):2138–2145CrossRefGoogle Scholar
  36. Hubbard GP, Wolffram S, de Vos R, Bovy A, Gibbins JM, Lovegrove JA (2006) Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr 96(3):482–488Google Scholar
  37. Hung H (2007) Dietary quercetin inhibits proliferation of lung carcinoma cells. Forum Nutr 60:146–157CrossRefGoogle Scholar
  38. Hwang IK, Lee CH, Yoo KY, Choi JH, Park OK, Lim SS, Kang IJ, Kwon DY, Park J, Yi JS, Bae YS, Won MH (2009) Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. J Med Food 12(5):990–995CrossRefGoogle Scholar
  39. Ige SF, Salawu EO, Olaleye SB, Adeeyo OA, Badmus J, Adeleke AA (2009) Onion (Allium cepa) extract prevents cadmium induced renal dysfunction. Indian J Nephrol 19(4):140–144CrossRefGoogle Scholar
  40. Izawa H, Kohara M, Aizawa K, Suganuma H, Inakuma T, Watanabe G, Taya K, Sagai M (2008) Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Biosci Biotechnol Biochem 72(5):1235–1241CrossRefGoogle Scholar
  41. Jalili T, Carlstrom J, Kim S, Freeman D, Jin H, Wu TC, Litwin SE, David SJ (2006) Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. J Cardiovasc Pharmacol 47(4):531–541CrossRefGoogle Scholar
  42. Javadzadeh A, Ghorbanihaghjo A, Bonyadi S, Rashidi MR, Mesgari M, Rashtchizadeh N, Argani H (2009) Preventive effect of onion juice on selenite-induced experimental cataract. Indian J Ophthalmol 57(3):185–189CrossRefGoogle Scholar
  43. Jung JY, Lim Y, Moon MS, Kim JY, Kwon O (2011) Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin-induced diabetic rats. Nutr Metab (Lond) 8(1):18CrossRefGoogle Scholar
  44. Kanter M, Altan MF, Donmez S, Ocakci A, Kartal ME (2007) The effects of quercetin on bone minerals, biomechanical behavior, and structure in streptozotocin-induced diabetic rats. Cell Biochem Funct 25:747–752CrossRefGoogle Scholar
  45. Khaki A, Fathiazad F, Nouri M, Khaki AA, Khamenehi HJ, Hamadeh M (2009) Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat. Folia Morphol (Warsz) 68(1):45–51Google Scholar
  46. Kim JW, Kim YS, Kyung KH (2004) Inhibitory activity of essential oils of garlic and onion against bacteria and yeasts. J Food Prot 67(3):499–504Google Scholar
  47. Kim SH, Jo SH, Kwon YI, Hwang JK (2011) Effects of onion (Allium cepa L.) extract administration on intestinal α-glucosidases activities and spikes in postprandial blood glucose levels in SD Rats model. Int J Mol Sci 12(6):3757–3769CrossRefGoogle Scholar
  48. Kook S, Kim GH, Choi K (2009) The antidiabetic effect of onion and garlic in experimental diabetic rats: meta-analysis. J Med Food 12(3):552–560CrossRefGoogle Scholar
  49. Krishnaswamy K (2008) Traditional Indian spices and their health significance. Asia Pac J Clin Nutr 17(Suppl 1):265–268Google Scholar
  50. Kumari K, Augusti KT (2007) Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 109(3):367–371CrossRefGoogle Scholar
  51. Lee SU, Lee JH, Choi SH, Lee JS, Ohnisi-Kameyama M, Kozukue N, Levin CE, Friedman M (2008) Flavonoid content in fresh, home-processed, and light-exposed onions and in dehydrated commercial onion products. J Agric Food Chem 56(18):8541–8548CrossRefGoogle Scholar
  52. Lines TC, Ono M (2006) FRS 1000, an extract of red onion peel, strongly inhibits phosphodiesterase 5A (PDE 5A). Phytomedicine 13(4):236–239CrossRefGoogle Scholar
  53. Lu X, Ross CF, Powers JR, Rasco BA (2011) Determination of quercetins in onion (Allium cepa) using infrared spectroscopy. J Agric Food Chem 59(12):6376–6382CrossRefGoogle Scholar
  54. Ly TN, Hazama C, Shimoyamada M, Ando H, Kato K, Yamauchi R (2005) Antioxidative compounds from the outer scales of onion. J Agric Food Chem 53(21):8183–8189CrossRefGoogle Scholar
  55. Lynett PT, Butts K, Vaidya V, Garrett GE, Pratt DA (2011) The mechanism of radical-trapping antioxidant activity of plant-derived thiosulfinates. Org Biomol Chem 9(9):3320–3330CrossRefGoogle Scholar
  56. Mantawy MM, Ali HF, Rizk MZ (2011) Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection. Rev Inst Med Trop Sao Paulo 53(3):155–163CrossRefGoogle Scholar
  57. Mastrangelo S, Tomassetti M, Carratù MR, Evandri MG, Bolle P (2006) Quercetin reduces chromosome aberrations induced by atrazine in the Allium cepa test. Environ Mol Mutagen 47(4):254–259CrossRefGoogle Scholar
  58. Mennen LI, Sapinho D, de Bree A, Arnault N, Bertrais S, Galan P, Hercberg S (2004) Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. J Nutr 134(4):923–926Google Scholar
  59. Meyers KJ, Rudolf JL, Mitchell AE (2008) Influence of dietary quercetin on glutathione redox status in mice. J Agric Food Chem 56(3):830–836CrossRefGoogle Scholar
  60. Munday R, Munday JS, Munday CM (2003) Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo. Free Radic Biol Med 34(9):1200–1211CrossRefGoogle Scholar
  61. Murota K, Mitsukuni Y, Ichikawa M, Tsushida T, Miyamoto S, Terao J (2004) Quercetin-4′-glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation. J Agric Food Chem 52(7):1907–1912CrossRefGoogle Scholar
  62. Murota K, Hotta A, Ido H, Kawai Y, Moon JH, Sekido K, Hayashi H, Inakuma T, Terao J (2007) Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans. J Med Invest 54(3–4):370–374CrossRefGoogle Scholar
  63. Naseri MK, Arabian M, Badavi M, Ahangarpour A (2008) Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat. Pak J Biol Sci 11(12):1569–1575CrossRefGoogle Scholar
  64. Nemeth K, Piskula MK (2007) Food content, processing, absorption and metabolism of onion flavonoids. Crit Rev Food Sci Nutr 47:397–409CrossRefGoogle Scholar
  65. Nishimura H, Higuchi O, Tateshita K, Tomobe K, Okuma Y, Nomura Y (2006) Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species. Biofactors 26(2):135–146CrossRefGoogle Scholar
  66. Obioha UE, Suru SM, Ola-Mudathir KF, Faremi TY (2009) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats. Biol Trace Elem Res 129(1–3):143–156CrossRefGoogle Scholar
  67. Ola-Mudathir KF, Suru SM, Fafunso MA, Obioha UE, Faremi TY (2008) Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Food Chem Toxicol 46(12):3604–3611CrossRefGoogle Scholar
  68. Park J, Kim J, Kim MK (2007) Onion flesh and onion peel enhance antioxidant status in aged rats. J Nutr Sci Vitaminol 53(1):21–29CrossRefGoogle Scholar
  69. Park SY, Yoo SS, Shim JH, Chin KB (2008) Physicochemical properties, and antioxidant and antimicrobial effects of garlic and onion powder in fresh pork belly and loin during refrigerated storage. J Food Sci 73(8):C577–C584CrossRefGoogle Scholar
  70. Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, Park SW, Ko EY, Oh SR, Jung YS (2009) Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. Eur J Nutr 48(4):235–242CrossRefGoogle Scholar
  71. Patel D, Shukla S, Gupta S (2007) Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol 30(1):233–245Google Scholar
  72. Pellegrini N, Miglio C, Del Rio D, Salvatore S, Serafini M, Brighenti F (2009) Effect of domestic cooking methods on the total antioxidant capacity of vegetables. Int J Food Sci Nutr 60(Suppl 2):12–22CrossRefGoogle Scholar
  73. Pratt DE (1965) Lipid antioxidants in plant tissues. J Food Sci 30:737–741CrossRefGoogle Scholar
  74. Ramos FA, Takaishi Y, Shirotori M, Kawaguchi Y, Tsuchiya K, Shibata H, Higuti T, Tadokoro T, Takeuchi M (2006) Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin. J Agric Food Chem 54(10):3551–3557CrossRefGoogle Scholar
  75. Rassi CM, Lieberherr M, Chaumaz G, Pointillart A, Cournot G (2005) Modulation of osteoclastogenesis in porcine bone marrow cultures by quercetin and rutin. Cell Tissue Res 319(3):383–393CrossRefGoogle Scholar
  76. Rocha BS, Gago B, Barbosa RM, Laranjinha J (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology 265(1–2):41–48CrossRefGoogle Scholar
  77. Rodríguez Galdón B, Rodríguez Rodríguez EM, Díaz Romero C (2008) Flavonoids in onion cultivars (Allium cepa L.). J Food Sci 73(8):C599–C605CrossRefGoogle Scholar
  78. Roldán-Marín E, Krath BN, Poulsen M, Binderup ML, Nielsen TH, Hansen M, Barri T, Langkilde S, Cano MP, Sánchez-Moreno C, Dragsted LO (2009) Effects of an onion by-product on bioactivity and safety markers in healthy rats. Br J Nutr 102(11):1574–1582CrossRefGoogle Scholar
  79. Scharf G, Prustomersky S, Knasmuller S, Schulte-Hermann R, Huber WW (2003) Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr Cancer 45(1):74–83CrossRefGoogle Scholar
  80. Sengupta A, Ghosh S, Bhattacharjee S (2004) Allium vegetables in cancer prevention: an overview. Asian Pac J Cancer Prev 5(3):237–245Google Scholar
  81. Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, Tete S, Madhappan B, Vecchiet J, De Lutiis MA, Caraffa A, Cerulli G (2006) Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents 20(3–4):47–52Google Scholar
  82. Shim SM, Yi HL, Kim YS (2011) Bioaccessibility of flavonoids and total phenolic content in onions and its relationship with antioxidant activity. Int J Food Sci Nutr 62(8):835–838CrossRefGoogle Scholar
  83. Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ (2004) Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 42(4):659–666CrossRefGoogle Scholar
  84. Shri R, Singh BK (2008) Neuroprotective effect of methanolic extracts of Allium cepa on ischemia and reperfusion-induced cerebral injury. Fitoterapia 79(2):86–96CrossRefGoogle Scholar
  85. Singh UP, Singh DP, Maurya S, Maheshwari R, Singh M, Dubey RS, Singh RB (2004) Investigation on the phenolics of some spices having pharmacotherapeuthic properties. J Herb Pharmacother 4(4):27–42CrossRefGoogle Scholar
  86. Singh BN, Singh BR, Singh RL, Prakash D, Singh DP, Sarma BK, Upadhyay G, Singh HB (2009) Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities. Food Chem Toxicol 47(6):1161–1167CrossRefGoogle Scholar
  87. Slimestad R, Fossen T, Vagen IM (2007) Onions: a source of unique dietary flavonoids. J Agric Food Chem 55(25):10067–10080CrossRefGoogle Scholar
  88. Smith C, Lombard KA, Peffley EB, Liu W (2003) Genetic analysis of quercetin in onion (Allium cepa L.) ‘Lady Raider’. Texas J Agric Nat Resource 16:24–28Google Scholar
  89. Stankevicius M, Akuneca I, Jakobsone I, Maruska A (2011) Comparative analysis of radical scavenging and antioxidant activity of phenolic compounds present in everyday use spice plants by means of spectrophotometric and chromatographic methods. J Sep Sci 34(11):1261–1267CrossRefGoogle Scholar
  90. Stratil P, Klejdus B, Kubán V (2006) Determination of total content of phenolic compounds and their antioxidant activity in vegetables – evaluation of spectrophotometric methods. J Agric Food Chem 54(3):607–616CrossRefGoogle Scholar
  91. Sun SY, Hail N Jr, Lotan R (2004) Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96(9):662–672CrossRefGoogle Scholar
  92. Suru SM (2008) Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats. Biometals 21(6):623–633CrossRefGoogle Scholar
  93. Taj Eldin IM, Ahmed EM, Elwahab HMA (2010) Preliminary study of the clinical hypoglycemic effects of Allium cepa (red onion) in type 1 and type 2 diabetic patients. Environ Health Insights 4:71–77Google Scholar
  94. Takahashi M, Shibamoto T (2008) Chemical compositions and antioxidant/anti-inflammatory activities of steam distillate from freeze-dried onion ( Allium cepa L.) sprout. J Agric Food Chem 56(22):10462–10467CrossRefGoogle Scholar
  95. Terao J, Kawai Y, Murota K (2008) Vegetable flavonoids and cardiovascular disease. Asia Pac J Clin Nutr 17(Suppl 1):291–293Google Scholar
  96. Veda S, Platel K, Srinivasan K (2008) Influence of food acidulants and antioxidant spices on the bioaccessibility of beta-carotene from selected vegetables. J Agric Food Chem 56(18):8714–8719CrossRefGoogle Scholar
  97. Vijayababu MR, Kanagaraj P, Arunkumar A, Ilangovan R, Dharmarajan A, Arunakaran J (2006) Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3. Oncol Res 16(2):67–74Google Scholar
  98. Vinson LA, Hao Y, Su X, Zubik L (1998) Phenol antioxidant quantity and quality in foods: vegetables. J Agric Food Chem 46:3630–3634CrossRefGoogle Scholar
  99. Viry E, Anwar A, Kirsch G, Jacob C, Diederich M, Bagrel D (2011) Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases. Int J Oncol 38(4):1103–1111Google Scholar
  100. Wenzel U, Herzog A, Kuntz S, Daniel H (2004) Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics 4(7):2160–2174CrossRefGoogle Scholar
  101. Williamson G, Manach C (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81(1 Suppl):243S–255SGoogle Scholar
  102. Wong RW, Rabie AB (2008) Effect of quercetin on bone formation. J Orthop Res 26(8):1061–1066CrossRefGoogle Scholar
  103. Wu XJ, Stahl T, Hu Y, Kassie F, Mersch-Sundermann V (2006) The production of reactive oxygen species and the mitochondrial membrane potential are modulated during onion oil-induced cell cycle arrest and apoptosis in A549 cells. J Nutr 136(3):608–613Google Scholar
  104. Xue YL, Ahiko T, Miyakawa T, Amino H, Hu F, Furihata K, Kita K, Shirasawa T, Sawano Y, Tanokura M (2011) Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion. J Agric Food Chem 59(11):5927–5934CrossRefGoogle Scholar
  105. Yamamoto Y, Aoyama S, Hamaguchi N, Rhi GS (2005) Antioxidative and antihypertensive effects of Welsh onion on rats fed with a high-fat high-sucrose diet. Biosci Biotechnol Biochem 69(7):1311–1317CrossRefGoogle Scholar
  106. Yang J, Meyers KJ, van der Heide J, Liu RH (2004) Varietal differences in phenolic content and antioxidant and antiproliferative activities of onions. J Agric Food Chem 52(22):6787–6793CrossRefGoogle Scholar
  107. Yang HS, Lee EJ, Moon SH, Paik HD, Nam K, Ahn DU (2011) Effect of garlic, onion, and their combination on the quality and sensory characteristics of irradiated raw ground beef. Meat Sci 89(2):202–208CrossRefGoogle Scholar
  108. Yiu JC, Liu CW, Fang DY, Lai YS (2009) Waterlogging tolerance of Welsh onion (Allium fistulosum L.) enhanced by exogenous spermidine and spermine. Plant Physiol Biochem 47(8):710–716CrossRefGoogle Scholar
  109. Yu CS, Lai KC, Yang JS, Chiang JH, Lu CC, Wu CL, Lin JP, Liao CL, Tang NY, Wood WG, Chung JG (2010) Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response. Phytother Res 24(2):163–168Google Scholar
  110. Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, Wu XT (2011) Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology 141(1):80–89CrossRefGoogle Scholar
  111. Zielinska D, Wiczkowski W, Piskula MK (2008) Determination of the relative contribution of quercetin and its glucosides to the antioxidant capacity of onion by cyclic voltammetry and spectrophotometric methods. J Agric Food Chem 56(10):3524–3531CrossRefGoogle Scholar
  112. Zurada JM, Kriegel D, Davis IC (2006) Topical treatments for hypertrophic scars. J Am Acad Dermatol 55(6):1024–1031CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Denys J. Charles
    • 1
  1. 1.Frontier Natural Products Co-opNorwayUSA

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