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Pathophysiology of Brain Death in Small Animal Models

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The Brain-Dead Organ Donor

Abstract

Clinically, consequences of brain death are linked to an inferior graft function and a more potent immune response. While our current understanding of the pathology of brain death remains largely descriptive, studies in rodents have been critical in delineating the inflammatory cascade initiated by brain death. More recent studies in mouse models and the inclusion of genetically modified strains are holding promise to unravel basic mechanisms in greater detail and to identify novel treatment targets.

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Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, University Hospital Regensburg, Regensburg, Germany

    Bernhard Floerchinger M.D.

  2. Division of Transplant Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Nicholas L. Tilney M.D. & Stefan G. Tullius M.D., Ph.D.

Authors
  1. Bernhard Floerchinger M.D.
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  2. Nicholas L. Tilney M.D.
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  3. Stefan G. Tullius M.D., Ph.D.
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Corresponding author

Correspondence to Stefan G. Tullius M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Tampa VA Medical Center, Surgery, University of South Florida, Bruce B. Downs Blvd 12901, Tampa, 33612, Florida, USA

    Dimitri Novitzky

  2. Thomas E. Starzl Transplantation Institu, Department of Surgery, University of Pittsburgh Medical Center, Lothrop Street 200, Pittsburgh, 15213, Pennsylvania, USA

    David K C Cooper

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Floerchinger, B., Tilney, N.L., Tullius, S.G. (2013). Pathophysiology of Brain Death in Small Animal Models. In: Novitzky, D., Cooper, D. (eds) The Brain-Dead Organ Donor. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4304-9_6

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  • DOI: https://doi.org/10.1007/978-1-4614-4304-9_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4303-2

  • Online ISBN: 978-1-4614-4304-9

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