Abstract
Severe head trauma and nontraumatic intracranial hemorrhages can cause major systemic dysfunction, which may affect every system of the potential organ donor. Without early and adequate support, these physiological changes can rapidly lead to the loss of potential organ donors or deterioration of the number and quality of procured organs. Good knowledge of these physiological changes, early and aggressive monitoring, and timely, appropriate management remain the cornerstone for optimal organ donation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Roth BJ, Sher L, Murray JA, et al. Cadaveric organ donor recruitment at Los Angeles county hospital: improvement after formation of a structured clinical, educational and administrative service. Clin Transplant. 2003;17:52–7.
Salim A, Velmahos GC, Brown C, Belzberg H, Demetriades D. Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma. 2005;58:991–4.
Salim A, Martin M, Brown C, Rhee P, Demetriades D, Belzberg H. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma. 2006;61:429–35.
Rosendale JD, Chabalewski FL, McBride MA, et al. Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant. 2002;2:761–8.
Wheeldon DR, Potter CD, Oduro A, Wallwork J, Large SR. Transforming the “unacceptable” donor: outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant. 1995;14:734–42.
Wood KE, Becker BN, McCartney JG, D’Alessandro AM, Coursin DB. Care of the potential organ donor. N Engl J Med. 2004;351:2730–9.
Schnuriger B, Inaba K, Branco BC, et al. Organ donation: an important outcome after resuscitative thoracotomy. J Am Coll Surg. 2010;211:450–5.
Christmas AB, Bogart RA, Etson KE, et al. The reward is worth the wait: a prospective analysis of 100 consecutive organ donors. AAST 69th Annual Meeting, Boston MA, Sept 21–24, 2010.
Inaba K, Branco BC, Lam L, et al. Organ donation and time to procurement: late is not too late. J Trauma. 2010;68:1362–6.
Salim A, Martin M, Brown C, et al. Complications of brain death: frequency and impact on organ retrieval. Am Surg. 2006;72:377–81.
Abdelnour T, Rieke S. Relationship of hormonal resuscitation therapy and central venous pressure on increasing organs for transplant. J Heart Lung Transplant. 2009;28:480–5.
Novitzky D, Horak A, Cooper DK, Rose AG. Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon. Transplant Proc. 1989;21:2567–9.
Novitzky D, Cooper DK, Rosendale JD, Kauffman HM. Hormonal therapy of the brain-dead organ donor: experimental and clinical studies. Transplantation. 2006;82:1396–401.
Cooper DK, Novitzky D, Wicomb WN. The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl. 1989;71:261–6.
Zaroff JG, Rosengard BR, Armstrong WF, et al. Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28–29, 2001, Crystal City, VA, USA. Circulation. 2002;106:836–41.
Hadjizacharia P, Salim A, Brown C, et al. Does the use of pulmonary artery catheters increase the number of organs available for transplantation? Clin Transplant. 2010;24:62–6.
Chen JM, Cullinane S, Spanier TB, et al. Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation. 1999;100:II244–6.
Talving P, Benfield R, Hadjizacharia P, Inaba K, Chan LS, Demetriades D. Coagulopathy in severe traumatic brain injury: a prospective study. J Trauma. 2009;66: 55–62.
Lustenberger T, Talving P, Kobayashi L, et al. Time course of coagulopathy in isolated severe traumatic brain injury. Injury. 2010;41:924–8.
Novitzky D, Cooper DK, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation. 1987; 43:852–4.
Novitzky D, Cooper DK, Morrell D, Isaacs S. Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine therapy. Transplantation. 1988;45:32–6.
Rosendale JD, Kauffman HM, McBride MA, et al. Hormonal resuscitation yields more transplanted hearts, with improved early function. Transplantation. 2003;75:1336–41.
Rosendale JD, Kauffman HM, McBride MA, Chabalewski FL, et al. Aggressive pharmacologic donor management results in more transplanted organs. Transplantation. 2003;75:482–7.
Salim A, Vassiliu P, Velmahos GC, et al. The role of thyroid hormone administration in potential organ donors. Arch Surg. 2001;136:1377–80.
Van Bakel AB, Pitzer S, Drake P, Kay NA, Stroud M, Sade RM. Early hormonal therapy stabilizes hemodynamics during donor procurement. Transplant Proc. 2004;36:2573–8.
Salim A, Martin M, Brown C, et al. Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation. Clin Transplant. 2007;21:405–9.
Venkateswaran RV, Dronavalli V, Lambert PA, et al. The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy. Transplantation. 2009;88:582–8.
Venkateswaran RV, Steeds RP, Quinn DW, et al. The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double-blind factorially designed controlled trial. Eur Heart J. 2009;30:1771–80.
Vairetti M, Ferrigno A, Rizzo V, et al. Liver damage during ischemia/reperfusion and glutathione: implications for potential organ donors. Transplant Proc. 2007;39:1768–70.
Ellett JD, Evans ZP, Fiorini JH, et al. The use of the Papworth cocktail is detrimental to steatotic livers after ischemia-reperfusion injury. Transplantation. 2008;86:286–92.
Iltis AS, Rie MA, Wall A. Organ donation, patients’ rights, and medical responsibilities at the end of life. Crit Care Med. 2009;37:310–5.
Simpkin AL, Robertson LC, Barber VS, Young JD. Modifiable factors influencing relatives’ decision to offer organ donation: systematic review. BMJ. 2009;339:b991.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Demetriades, D., Lam, L. (2013). Assessment, Monitoring, and Management of Brain-Dead Potential Organ Donors in the USA. In: Novitzky, D., Cooper, D. (eds) The Brain-Dead Organ Donor. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4304-9_17
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4304-9_17
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-4303-2
Online ISBN: 978-1-4614-4304-9
eBook Packages: MedicineMedicine (R0)