Advertisement

Cryotherapy and Cryodebridement

  • Ramez SunnaEmail author
Chapter

Abstract

Endobronchial cryotherapy is one of multiple bronchoscopic modalities that can be performed using rigid or flexible bronchoscopes. It is used primarily in the treatment of benign and malignant central airway obstruction, where cold energy has destructive effects on the local microcirculation as well as at the cellular level, and repeated freeze-thaw cycles result in sloughing of tissue relieving the obstruction. Cryotherapy is also used for obtaining adequate endobronchial and transbronchial lung biopsies with an excellent safety profile. This chapter discusses the scientific basis of cryotherapy, procedural techniques, and the clinical evidence behind this practice.

Keywords

Infective Endocarditis Argon Plasma Coagulation Transbronchial Biopsy Flexible Bronchoscope Rigid Bronchoscope 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

I would like to gratefully acknowledge Dr. Adnan Majid for his helpful contributions and enormous support during the process of writing this manuscript.

Suggested Reading

  1. 1.
    Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in bronchoscopy of lung cancers. Eur Respir J. 2006;28:200–18.PubMedCrossRefGoogle Scholar
  2. 2.
    Maiwand O, Glynne-Jones R, Chambers J, et al. Direct cryosurgery for inoperable metastatic disease of the lung. Ann Thorac Surg. 2006;81:718–21.PubMedCrossRefGoogle Scholar
  3. 3.
    Thomford NR, Wilson WH, Blackburn ED, et al. Morphological changes in canine trachea after freezing. Cryobiology. 1970;7:19–26.PubMedCrossRefGoogle Scholar
  4. 4.
    Sanderson DR, Neel HB, Payne WS, et al. Cryotherapy for bronchogenic carcinoma: report of a case. Mayo Clin Proc. 1975;50:435–7.PubMedGoogle Scholar
  5. 5.
    Marasso A, Gallo E, Massaglia GM, et al. Cryosurgery in bronchoscopic treatment of tracheobronchial stenosis. Indications, limits, personal experience. Chest. 1993;103:472–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Manzur P. The role of intracellular freezing in the death of cells cooled at supraoptimal rates. Cryobiology. 1977;14:251–72.CrossRefGoogle Scholar
  7. 7.
    Homasson JP, Renault P, Angebault M, et al. Bronchoscopic cryotherapy for airway strictures caused by tumors. Chest. 1986; 90:159–64.PubMedCrossRefGoogle Scholar
  8. 8.
    Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat. 2004;3:143–50.PubMedGoogle Scholar
  9. 9.
    Mathur PN, Wolf KM, Bush MF, et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996;110:718–23.PubMedCrossRefGoogle Scholar
  10. 10.
    Walsh DA, Maiwand MO, Nath AR, et al. Bronchoscopic cryotherapy for advanced bronchial carcinoma. Thorax. 1990;45:509–13.PubMedCrossRefGoogle Scholar
  11. 11.
    Hetze M, Hetze J, Schumann C, et al. Cryocanalization: new approach for immediate management of acute airway obstruction. J Thorac Cardiovasc Surg. 2004;127:1427–31.CrossRefGoogle Scholar
  12. 12.
    Babiak A, Hetzel J, Krishna G, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration. 2009;78(2):203–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Pajares V, Torrego A, Puzo, et al. Transbronchial lung biopsy using cryoprobes. Arch Bronconeumol. 2010;46(3):111–5.PubMedCrossRefGoogle Scholar
  14. 14.
    Aktas Z, Gunay E, TaciHoca N, et al. Endobronchial cryobiopsy or forceps biopsy for lung cancer diagnosis. Ann Thorac Surg. 2010;5(4):242–6.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pulmonary, Critical Care, & Environmental MedicineUniversity of Missouri Health SystemColumbiaUSA

Personalised recommendations