Abstract
Endobronchial cryotherapy is one of multiple bronchoscopic modalities that can be performed using rigid or flexible bronchoscopes. It is used primarily in the treatment of benign and malignant central airway obstruction, where cold energy has destructive effects on the local microcirculation as well as at the cellular level, and repeated freeze-thaw cycles result in sloughing of tissue relieving the obstruction. Cryotherapy is also used for obtaining adequate endobronchial and transbronchial lung biopsies with an excellent safety profile. This chapter discusses the scientific basis of cryotherapy, procedural techniques, and the clinical evidence behind this practice.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in bronchoscopy of lung cancers. Eur Respir J. 2006;28:200–18.
Maiwand O, Glynne-Jones R, Chambers J, et al. Direct cryosurgery for inoperable metastatic disease of the lung. Ann Thorac Surg. 2006;81:718–21.
Thomford NR, Wilson WH, Blackburn ED, et al. Morphological changes in canine trachea after freezing. Cryobiology. 1970;7:19–26.
Sanderson DR, Neel HB, Payne WS, et al. Cryotherapy for bronchogenic carcinoma: report of a case. Mayo Clin Proc. 1975;50:435–7.
Marasso A, Gallo E, Massaglia GM, et al. Cryosurgery in bronchoscopic treatment of tracheobronchial stenosis. Indications, limits, personal experience. Chest. 1993;103:472–4.
Manzur P. The role of intracellular freezing in the death of cells cooled at supraoptimal rates. Cryobiology. 1977;14:251–72.
Homasson JP, Renault P, Angebault M, et al. Bronchoscopic cryotherapy for airway strictures caused by tumors. Chest. 1986; 90:159–64.
Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat. 2004;3:143–50.
Mathur PN, Wolf KM, Bush MF, et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996;110:718–23.
Walsh DA, Maiwand MO, Nath AR, et al. Bronchoscopic cryotherapy for advanced bronchial carcinoma. Thorax. 1990;45:509–13.
Hetze M, Hetze J, Schumann C, et al. Cryocanalization: new approach for immediate management of acute airway obstruction. J Thorac Cardiovasc Surg. 2004;127:1427–31.
Babiak A, Hetzel J, Krishna G, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration. 2009;78(2):203–8.
Pajares V, Torrego A, Puzo, et al. Transbronchial lung biopsy using cryoprobes. Arch Bronconeumol. 2010;46(3):111–5.
Aktas Z, Gunay E, TaciHoca N, et al. Endobronchial cryobiopsy or forceps biopsy for lung cancer diagnosis. Ann Thorac Surg. 2010;5(4):242–6.
Acknowledgment
I would like to gratefully acknowledge Dr. Adnan Majid for his helpful contributions and enormous support during the process of writing this manuscript.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sunna, R. (2013). Cryotherapy and Cryodebridement. In: Ernst, A., Herth, F. (eds) Principles and Practice of Interventional Pulmonology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4292-9_33
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4292-9_33
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-4291-2
Online ISBN: 978-1-4614-4292-9
eBook Packages: MedicineMedicine (R0)