Deciphering Fate Decision in Normal and Cancer Stem Cells: Mathematical Models and Their Experimental Verification

  • Gili Hochman
  • Zvia Agur
Part of the Lecture Notes on Mathematical Modelling in the Life Sciences book series (LMML)


All tissues in the body are derived from stem cells (SCs). SCs are undifferentiated cells with two essential properties: unlimited replication capacity and the ability to differentiate into one or more specialized cell types. Embryonic SCs are pluripotent, meaning that they can give rise to nearly all cell types. Non-embryonic, adult SCs are found in various tissues and are capable of generating a limited set of tissue-specific cell types. The first discovered and most extensively studied type of adult SC is the hematopoietic SC, found in the bone marrow, which can give rise to all lineages of mature blood cells [12, 84]. Organ-specific SCs have been identified in many other tissues, including the liver, skin, brain, and mammary gland (see [19] for review).


Quorum Sense Cellular Automaton Cellular Automaton Model Probabilistic Cellular Automaton Ordinary Differential Equation System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Yuri Kogan and Karin Halevi-Tobias for helpful discussions and support, Karen Marron for helpful advice and careful editing of the manuscript, and the Chai Foundation for supporting the study.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute for Medical BioMathematicsBene AtarothIsrael

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