Skip to main content
SpringerLink
Log in

Neovascular Glaucoma

  • Chapter
  • First Online:
Clinical Glaucoma Care

  • 1801 Accesses

Abstract

This chapter describes the pathophysiology of neovascular glaucoma and presents a differential diagnosis for rubeosis iridis. A detailed description of the clinical presentation and expected exam findings and clinical course of disease are outlined. Special attention is given to neovascular glaucoma as a result of diabetes, as well as central retinal vein occlusion. Treatment strategies are then detailed, including medical treatments with the newest anti-VEGF agents, laser treatments, as well as surgical options with the latest evidence-based recommendations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Weiss DI, Shaffer RN, Nehrenberg TR. Neovascular glaucoma complicating carotid-cavernous fistula. Arch Ophthalmol. 1963;69:304–7.

    Article  PubMed  CAS  Google Scholar 

  2. Wand M. Neovascular glaucoma. In: Ritch R, Shields MB, Krupin T, editors. The glaucomas – clinical science. 2nd ed. St. Louis: Mosby; 1996. p. 1073–129.

    Google Scholar 

  3. Sivak-Callcott JA, O’Day DM, Gass JD, et al. Evidence-based recommendations for the diagnosis and treatment of neovascular glaucoma. Ophthalmology. 2001;108:1767–76.

    Article  PubMed  CAS  Google Scholar 

  4. Hayreh SS. Neovascular glaucoma. Prog Retin Eye Res. 2007;26(5):470–85.

    Article  PubMed  Google Scholar 

  5. Yoneya S, Numaga T, Yamazaki S, et al. Neovascularization of iris demonstrated in kittens with ROP. Nippon Ganka Gakkai Zasshi. 1982;86(9):1251–61.

    PubMed  CAS  Google Scholar 

  6. Bron AJ, Tripathi RC, Tripathi BJ. The choroid and uveal vessels. In: Bron AJ, Tripathi RC, Tripathi BJ, editors. Wolff’s anatomy of the eye and orbit. 8th ed. London: Chapman & Hall Medical; 1997. p. 377.

    Google Scholar 

  7. Sassani JT, Eagle RC. The myofibroblasts component of rubeosis iridis. Ophthalmology. 1983;90:721–8.

    Article  PubMed  Google Scholar 

  8. Diabetes control and complications trial research group. Progression of retinopathy with intensive versus conventional treatment in the Diabetes Control and Complications Trial. Ophthalmology. 1995;102:647–61.

    Article  Google Scholar 

  9. Ohnishi Y, et al. Fluorescein gonioangiography in diabetic neovascularization. Graefes Arch Clin Exp Ophthalmol. 1994;232:199–204.

    Article  PubMed  CAS  Google Scholar 

  10. Diabetic retinopathy study group. Preliminary report on effects of photocoagulation therapy. Am J Ophthalmol. 1976;81:383–96.

    Google Scholar 

  11. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581–611.

    Article  PubMed  CAS  Google Scholar 

  12. Andreoli CM, Miller JW. Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol. 2007;18:502–8.

    Article  PubMed  Google Scholar 

  13. Avery RL. Regression of retinal and iris neovascularization after intravitreal bevacizumab (Avastin) treatment. Retina. 2006;26:354–6.

    Article  Google Scholar 

  14. Davidorf FH, Mouser JG, Derick RJ. Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injection. Retina. 2006;26:354–6.

    Article  PubMed  Google Scholar 

  15. Kahook MY, Schuman JS, Noecker RJ. Intravitreal bevacizumab in a patient with neovascular glaucoma. Ophthalmic Surg Lasers Imaging. 2006;37:144–6.

    PubMed  Google Scholar 

  16. Paula JS, Jorge R, Costa RA, et al. Short-term results of intravitreal bevacizumab (Avastin) on anterior segment neovascularization in neovascular glaucoma. Acta Ophthalmol Scand. 2006;84:556–7.

    Article  Google Scholar 

  17. Grisanti S, Bieter S, Peters S, et al. The Tuebingen bevacizumab study group. Intravitreal bevacizumab (Avastin) in the treatment of neovascular glaucoma. Am J Ophthalmol. 2006;142:158–60.

    Article  PubMed  CAS  Google Scholar 

  18. Yazdani S, Hendi K, Pakravan M. Intravitreal bevacizumab (Avastin) injection for neovascular glaucoma. J Glaucoma. 2007;16:437–9.

    Article  PubMed  Google Scholar 

  19. Wakabayashi T, Oshima Y, Sakaguchi H, Ikuno Y, Miki A, Gomi F, Otori Y, Kamei M, Kusaka S, Tano Y. Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases. Ophthalmology. 2008;115(9):1571–80, 1580.e1–3.

    Google Scholar 

  20. Bakri SJ, Snyder R, Reid JM, et al. Pharmacokinetics of intravitreal ranibizumab (Lucentis). Ophthalmology. 2007;114:2179–82.

    Article  PubMed  Google Scholar 

  21. Katz LJ, Costa VP, Spaeth GL. Filtration surgery. In: Ritch R, Shields MB, Krupin T, editors. The glaucomas. 2nd ed. St. Louis: Mosby; 1996. p. 1682. Ch 83.

    Google Scholar 

  22. Tsai JC, Feuer WJ, Parrish 2nd RK, et al. 5-Flurouracil filtering surgery and neovascular glaucoma – long-term follow-up of the original pilot study. Ophthalmology. 1995;102:887–92.

    Article  PubMed  CAS  Google Scholar 

  23. Kitazawa Y, Kawase K, Matsushita H, et al. Trabeculectomy with mitomycin. A comparative study with fluorouracil. Arch Ophthalmol. 1991;109:1693–8.

    Article  PubMed  CAS  Google Scholar 

  24. Sisto D, Vetrugno M, Trabucco T, et al. The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate-term follow-up. Acta Ophthalmol Scand. 2007;85:267–71.

    Article  PubMed  CAS  Google Scholar 

  25. Nilforushan N, Yadgari M, Kish SK, Nassiri N. Subconjunctival bevacizumab versus mitomycin C adjunctive to trabeculectomy. Am J Ophthalmol. 2012;153(2):352–357.e1.

    Google Scholar 

  26. Chen CH, Lai IC, Wu PC, Chen YJ, Chen YH, Lee JJ, Liu YC, Kuo HK. Adjunctive intravitreal bevacizumab-combined trabeculectomy versus trabeculectomy alone in the treatment of neovascular glaucoma. J Ocul Pharmacol Ther. 2010 Feb;26(1):111–8.

    Google Scholar 

  27. Sidoti PA, Morinelli EN, Heuer DK, et al. Tissue plasminogen activator and glaucoma drainage implants. J Glaucoma. 1995;4:258–62.

    PubMed  CAS  Google Scholar 

  28. Shen CC, Salim S, Du H, Netland PA. Trabeculectomy versus Ahmed Glaucoma Valve implantation in neovascular glaucoma. Clin Ophthalmol. 2011;5:281–6.

    PubMed  Google Scholar 

  29. Every SG, Molteno AC, Bevin TH, et al. Long-term results of Molteno implant insertion in cases of neovascular glaucoma. Arch Ophthalmol. 2006;124:355–60.

    Article  PubMed  Google Scholar 

  30. Broadway DC, Tester M, Schulzer M, et al. Survival analysis for success of Molteno tube implants. Br J Ophthalmol. 2001;85:689–95.

    Article  PubMed  CAS  Google Scholar 

  31. Susanna Jr R. Latin American Glaucoma Society. Partial Tenon’s capsule resection with adjunctive MMC in Ahmed glaucoma valve implant surgery. Br J Ophthalmol. 2003;87:994–8.

    Article  PubMed  Google Scholar 

  32. Costa VP, Azuara-Blanco A, Netland PA, et al. Efficacy and safety of adjunctive mitomycin-C during Ahmed glaucoma valve implantation: a prospective randomized clinical trial. Ophthalmology. 2004;111:1071–6.

    Article  PubMed  Google Scholar 

  33. Cantor L, Burgoyne J, Sanders S, et al. The effect of mitomycin C on Molteno implant surgery: a 1-year randomized masked, prospective study. J Glaucoma. 1998;7:240–6.

    Article  PubMed  CAS  Google Scholar 

  34. Duan X, Jiang Y, Qing G. Long-term follow-up study on Hunan aqueous drainage implantation combined with mitomycin-C for refractory glaucoma. Yan Ke Xue Bao Bian Ji Bu. 2003;19(2):81–5.

    Google Scholar 

  35. Lima FE, Magacho L, Carvalho DM, et al. A prospective, comparative study between endoscopic cyclophotocoagulation and the Ahmed drainage implant in refractory glaucoma. J Glaucoma. 2004;13:233–7.

    Article  PubMed  Google Scholar 

  36. Ma KT, Yang JY, Kim JH, Kim NR, Hong S, Lee ES, Seong GJ, Kim CY. Surgical results of Ahmed valve implantation with intraoperative bevacizumab injection in patients with neovascular glaucoma. J Glaucoma. 2012;21(5):331–6.

    Article  PubMed  Google Scholar 

  37. Mahdy RA, Nada WM, Fawzy KM, Alnashar HY, Almosalamy SM. Efficacy of Intravitreal Bevacizumab With Panretinal Photocoagulation Followed by Ahmed Valve Implantation in Neovascular Glaucoma. J Glaucoma. 2012 Jul 11.

    Google Scholar 

  38. Callens C, D’Hondt K, Zeyen T. The long-term effect of diode laser cyclodestruction on intraocular pressure. Bull Soc Belge Ophthalmol. 2003;289:81–6.

    Google Scholar 

  39. Hamard P, Gayraud JM, Kopel J, et al. Treatment of refractory glaucomas by transscleral cyclophotocoagulation using semiconductor diode laser. Analysis of 50 patients followed-up over 19 months. J Fr Ophthalmol. 1997;20:125–33.

    CAS  Google Scholar 

  40. Kahook MY, Lathrop KL, Noecker RJ. One-site versus two-site cyclophotocoagulation. J Glaucoma. 2007;16:527–30.

    Article  PubMed  Google Scholar 

  41. Ghosh S, Singh D, Ruddle JB, Shiu M, Coote MA, Crowston JG. Combined diode laser cyclophotocoagulation and intravitreal bevacizumab (Avastin) in neovascular glaucoma. Clin Experiment Ophthalmol. 2010 May;38(4):353–7.

    Google Scholar 

  42. Duke-Elder S. Secondary glaucomas. In: Duke-Elder S, Jay B, editors. System of ophthalmology, Diseases of the lens and vitreous; glaucoma and hypotony, vol. XI. London: Henry Kimpton; 1969. p. 667–77.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gavin Herbert Eye Institute, University of California, Irvine, 850 Health Sciences Road, Irvine, CA, 92697, USA

    Sameh Mosaed MD

  2. Department of Ophthalmology and Pathology, Douglas Hospital, University of California, Irvine, 101 The City Drive South; Bldg 1 Douglas Hospital; Rm 3628, Orange, 92868-4805, CA, USA

    Donald Minckler MD, MS

Authors
  1. Sameh Mosaed MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Donald Minckler MD, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sameh Mosaed MD .

Editor information

Editors and Affiliations

  1. Rocky Visa University, Littleton, Colorado, USA

    John R. Samples

  2. Visual Health Center, Palm Springs, Florida, USA

    Paul N. Schacknow

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mosaed, S., Minckler, D. (2014). Neovascular Glaucoma. In: Samples, J., Schacknow, P. (eds) Clinical Glaucoma Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4172-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-4172-4_18

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4171-7

  • Online ISBN: 978-1-4614-4172-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation