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Tremor in Childhood

Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Tremor particularly affects the upper limbs but can involve almost any part of the body including the head, face, eyelids, tongue, vocal cords, and trunk. In a Consensus Statement of the Movement Disorders Society, tremor is defined as “a rhythmic, involuntary, oscillatory movement of a body part” (Deuschl et al. 1998). As with most definitions of movement disorders there is an immediate problem with the words used, in this case with “rhythmic.” In Webster’s dictionary there are 10 definitions of “rhythm” the first being “movement or procedure with uniform or patterned recurrence of a beat, accent or the like.” In current clinical practice when there are regular oscillations the term tremor is used with “rhythmic” and “regular” essentially having the same meaning.

Keywords

Children Newborn Dopamine Metabolism 

References

  1. Aicardi J. Disorders of the ocular motor and visual functions. In: Diseases of the nervous system in childhood. 2nd ed. London: Mac Keith; 1998. p. 667–88.Google Scholar
  2. Al-Hayk K, LeDoux MS. Epilepsia partialis continua mistaken for Parkinson’s disease. Mov Disord. 2003;18:107.PubMedCrossRefGoogle Scholar
  3. Andrew J, Fowler CJ, Harrison MJG. Tremor after head injury and its treatment by stereotaxic surgery. J Neurol Neurosurg Psychiatry. 1982;45:815–19.PubMedCrossRefGoogle Scholar
  4. Anthony J, Ouvrier RA, Wise GA. Spasmus Nutans, a mistaken identity. Arch Neurol. 1980;37:373–5.CrossRefGoogle Scholar
  5. Bain PG, Findley LJ, Britton TC, et al. Primary writing tremor. Brain. 1995;118:1461–72.PubMedCrossRefGoogle Scholar
  6. Benton JW, Nellhaus G, Huttenlocher P, et al. The bobble-head doll syndrome. Report of a unique truncal tremor associated with third ventricular cyst and hydrocephalus in children. Neurology. 1966;16:725–9.CrossRefGoogle Scholar
  7. Bodzioch M, Lapicka-Brodzioch K, Rudzinska, et al. Severe dystonic encephalopathy without hyperphenylalaninemia associated with an 18-bp deletion within the proximal GCH1 promotor. Mov Disord. 2011;26:337–40.PubMedCrossRefGoogle Scholar
  8. Brun L, Ngu LH, Keng WT, et al. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Neurology. 2010;75:64–71.PubMedCrossRefGoogle Scholar
  9. Brust JCM. Substance abuse and movement disorders. Mov Disord. 2010;25:2010–20.PubMedCrossRefGoogle Scholar
  10. Campistol-Plana J, Majumdar A, Fernández-Alvarez E. Palatal tremor in childhood: clinical and therapeutic considerations. Dev Med Child Neurol. 2006;48:982–4.PubMedCrossRefGoogle Scholar
  11. Canavese C, Ciano C, Zorzi G, et al. Polymyography in the diagnosis of childhood onset movement disorders. Eur J Paediatr Neurol. 2008;12:480–3.PubMedCrossRefGoogle Scholar
  12. Cardenas JF, Amato RS. Compound heterozygous polymerase gamma gene mutation in a patient with Alpers disease. Semin Pediatr Neurol. 2010;17:62–4.PubMedCrossRefGoogle Scholar
  13. Cockerell OC, Rothwell J, Thompson PD, et al. Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK. Brain. 1996;119:393–407.PubMedCrossRefGoogle Scholar
  14. Coulter DL, Allen RJ. Benign neonatal sleep myoclonus. Arch Neurol. 1982;39:191–2.PubMedCrossRefGoogle Scholar
  15. Dale RC, Nasti JJ, Peters GB. Familial 7q21.3 microdeletion involving epsilon-sarcoglycan causing myoclonus dystonia, cognitive impairment, and psychosis. Mov Disord. 2011;26(9):1774–5.PubMedCrossRefGoogle Scholar
  16. de Rijk-Van Andel JF, Gabreels FJ, Van Den Heuvel LP, et al. L-dopa responsive infantile hypokinetic rigid parkinsonism due to tyrosine hydroxylase deficiency. Neurology. 2000;55:1926–8.PubMedCrossRefGoogle Scholar
  17. De Vivo D, Trifiletti RR, Jacobson RI, et al. Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhacia, seizures and developmental delay. NEJM. 1991;325:703–9.PubMedCrossRefGoogle Scholar
  18. Denny-Brown D, Pennybaker JB. Fibrillation and fasciculation in voluntary muscle. Brain. 1938;61:311–34.CrossRefGoogle Scholar
  19. Deuschl G, Elbe R. Essential tremor – neurodegenerative or nondegenerative disease towards a working definition of ET. Mov Disord. 2009;24:2033–41.PubMedCrossRefGoogle Scholar
  20. Deuschl G, Toro C, Valls-Solé J, et al. Symptomatic and essential palatal tremor. 1. Clinical, physiological and MRI analysis. Brain. 1994;117:775–88.PubMedCrossRefGoogle Scholar
  21. Deuschl G, Bain P, Brin M, et al. Consensus Statement of the Movement Disorder Society on Tremor. Mov Disord. 1998;13 suppl 3:2–23.PubMedGoogle Scholar
  22. DiMario FJ. Childhood head tremor. J Child Neurol. 2000;15:22–5.PubMedCrossRefGoogle Scholar
  23. Elbe R, Deuschl G. Milestones in tremor research. Mov Disord. 2011;26:1096–105.CrossRefGoogle Scholar
  24. Emery ES, Homans AC, Colleti RB. Vitamin B12 deficiency: a cause of abnormal movements in infants. Pediatrics. 1997;99:255–6.PubMedCrossRefGoogle Scholar
  25. Factor SA, Coni RJ, Cowger M, Rosenblum EL. Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis deficit. Neurology. 1991;41:930–2.PubMedCrossRefGoogle Scholar
  26. Fahn S, Jankovic J. Tremors diagnosis and management. In: Principles and practice of movement disorders. Philadelphia: Churchill Livingstone; 2007a. p. 451–78.Google Scholar
  27. Fahn S, Jankovic J. Psychogenic movement disorders. In: Principles and practice of movement disorders. Philadelphia: Churchill Livingstone; 2007b. p. 597–611.Google Scholar
  28. Fazzi E, Lanners J, Danova S. Stereotyped behaviours in blind children. Brain Dev. 1999;21: 522–8.PubMedCrossRefGoogle Scholar
  29. Ferlazzo E, Morgante F, Rizzo V, et al. Successful treatment of Holmes tremor by levetiracetam. Mov Disord. 2008;23:2101–3.PubMedCrossRefGoogle Scholar
  30. Fernandez-Alvarez E, Aicardi J. Movement Disorders with tremor as the main clinical manifestation. In: Movement disorders in children. London: MacKeith Press, 2001; p. 43-62.Google Scholar
  31. Graham SM, Arvela OM, Wise GA. Long term neurological consequences of nutritional B 12 deficiency in infants. J Pediatr. 1992;121:710–4.PubMedCrossRefGoogle Scholar
  32. Grattan-Smith PJ, Wilcken B, Procopis PG, Wise GA. The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements. Mov Disord. 1997;12:39–46.PubMedCrossRefGoogle Scholar
  33. Grattan-Smith PJ, Wevers RA, Steenbergen-Spanjers GC. Tyrosine hydroxylase deficiency: clinical manifestations of catecholamine insufficiency in infancy. Mov Disord. 2002;17:354–9.PubMedCrossRefGoogle Scholar
  34. Higginbottom MC, Sweetman L, Nylian WL. A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurological abnormalities in a vitamin B 12-deficient breast fed infant of a strict vegetarian. N Eng J Med. 1978;299:317–23.CrossRefGoogle Scholar
  35. Holmes G. On certain tremors in organic cerebral lesions. Brain. 1904;27:327–75.CrossRefGoogle Scholar
  36. Hoogenraad TU. Major problems in neurology, Vol 30, Wilson’s disease, vol. 30. London: WB Saunders; 1996. p. 85.Google Scholar
  37. Hottinger-Blanc PM, Ziegler AL, Deonna T. A special type of head stereotypies in children with developmental (?cerebellar) disorder: description of 8 cases and literature review. Eur J Paediatr Neurol. 2002;6:143–52.PubMedCrossRefGoogle Scholar
  38. Hyman NM, Dennis PD, Sinclair GA. Tremor due to sodium valproate. Neurology. 1979;29:1177–80.PubMedCrossRefGoogle Scholar
  39. Jadhav M, Webb JKG, Vaishnava S, Baker SJ. Vitamin B12 deficiency in Indian infants. Lancet. 1962;2:903–7.PubMedCrossRefGoogle Scholar
  40. Jankovic J, Madisetty J, Vuong KD. Essential tremor among children. Pediatrics. 2004;114:1203–5.PubMedCrossRefGoogle Scholar
  41. Jarman PR, Wood NW, Davis MT, et al. Hereditary geniospasm: linkage to chromosome 9q13-q21 and evidence for genetic heterogeneity. Am J Hum Genet. 1997;61:928–33.PubMedCrossRefGoogle Scholar
  42. Kaelan C, Harper C, Viera BI. Acute encephalopathy and death due to petrol sniffing: neuropathological findings. Aust NZ J Med. 1986;16:804–7.Google Scholar
  43. Kahn E, Falcke HC. A syndrome simulating encephalitis affecting children recovering from malnutrition (kwashiorkor). J Pediatr. 1956;49:37–45.PubMedCrossRefGoogle Scholar
  44. Keller S, Dure LS. Tremor in childhood. Semin Pediatr Neurol. 2009;16:60–70.PubMedCrossRefGoogle Scholar
  45. Kipps CM, Fung VS, Grattan-Smith P, et al. Movement disorder emergencies. Mov Disord. 2005;20:322–34.PubMedCrossRefGoogle Scholar
  46. Korenke GC, Christian HJ, Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: an extrapyramidal movement disorder with oculogyric crises. Eur J Pediatr Neurol. 1997;2–3:67–71.CrossRefGoogle Scholar
  47. Lazar RB, Ho SU, Melen O, Daghestani AN. Multifocal central nervous system damage caused by toluene abuse. Neurology. 1983;33:1337–440.PubMedCrossRefGoogle Scholar
  48. Lewis PR, Donoghue MB, Hocking A, et al. Tremor syndrome associated with fungal toxin: sequelae of food contamination. Med J Aust. 2005;182:582–4.PubMedGoogle Scholar
  49. Louis ED, Ferreira JJ. How common is the commonest adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534–41.PubMedCrossRefGoogle Scholar
  50. Louis ED, Ford B, Frucht S, et al. Risk of tremor and impairment from tremor in relatives of patients with essential tremor: a community-based family study. Ann Neurol. 2001a;49: 761–9.PubMedCrossRefGoogle Scholar
  51. Louis ED, Dure LS, Pullman S. Essential tremor in childhood: a series of nineteen cases. Mov Disord. 2001b;16:921–3.PubMedCrossRefGoogle Scholar
  52. Manto M. Tremorgenesis: a new conceptual scheme using reciprocally innervated circuit of neurons. J Transl Med. 2008;6:71.PubMedCrossRefGoogle Scholar
  53. Marsden CD. Origins of normal and pathological tremor. In: Findlay LJ, Capildeo R, editors. Movement disorders: tremor. New York: Oxford University Press; 1984. p. 37–84.Google Scholar
  54. Miller DT. Genetic testing for autism: recent advances and clinical implications. Expert Rev Mol Diagn. 2010;10:837–40.PubMedCrossRefGoogle Scholar
  55. Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987;37:1837–44.PubMedCrossRefGoogle Scholar
  56. Moosa A, Dubowitz V. Spinal muscular atrophy in Childhood. Two clues to clinical diagnosis. Arch Dis Child 1973;48:386–88.Google Scholar
  57. Mostile MD, Jankovic J. Alcohol in essential tremor and other movement disorders. Mov Disord. 2010;25:2274–84.PubMedCrossRefGoogle Scholar
  58. Nellhaus G. Abnormal head movements of young children. Dev Med Child Neurol. 1983;25: 384–9.PubMedCrossRefGoogle Scholar
  59. Neville B G R, Parascandalo R, Farrugia R, Felice A. Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder. Brain 2005;128:2291–6.Google Scholar
  60. Ouvrier RA, McLeod JG, Pollard JD. Chronic inflammatory demyelinating polyradiculoneuropathy. In: Peripheral neuropathy in childhood. 2nd ed. London: MacKeith Press; 1999. p. 55–66.Google Scholar
  61. Peker S, Isik U, Akgun Y, Ozek M. Deep brain stimulation for Holmes’ tremor related to a thalamic abscess. Childs Nerv Syst. 2008;24:1057–62.PubMedCrossRefGoogle Scholar
  62. Pons R, Collins A, Rotstein M, et al. The spectrum of movement disorders in Glut-1 deficiency. Mov Disord. 2010;25:275–81.PubMedCrossRefGoogle Scholar
  63. Rajput AH, Offord KP, Beard CM, et al. Essential tremor in Rochester, Minnesota; a 45 year study. J Neurol Neurosurg Psychiatry. 1984;47:466–70.PubMedCrossRefGoogle Scholar
  64. Riggs JE, Gutman L, Schochet S. Contraction pseudotremor of chronic denervation. Arch Neurology. 1983;40:518–9.CrossRefGoogle Scholar
  65. Rothwell JC, Traub MM, Marsden CD. Primary writing tremor. J Neurol Neurosurg Psychiatry. 1979;42:1106–14.PubMedCrossRefGoogle Scholar
  66. Roubergue A, Apartis E, Mesnage V, et al. Dystonic tremor caused by mutation of the glucose transporter gene GLUT1. J Inherit Metab Dis. 2011;34:483–88.PubMedCrossRefGoogle Scholar
  67. Scher MS. Seizures in the newborn infant. Diagnosis, treatment and outcome. Clin Perinatol. 1997;24:735–72.PubMedGoogle Scholar
  68. Schwingenschuh P, Ruge D, Edwards MJ, et al. Adult onset asymmetric upper limb tremor misdiagnosed as Parkinson’s disease: a clinical and electrophysiological study. Mov Disord. 2010;25: 560–9.PubMedCrossRefGoogle Scholar
  69. Segawa M, Nomura Y, Nishiyama N. Autosomal dominant guanasine triphosphate cyclohydrolase 1 deficiency (Segawa Disease). Ann Neurol. 2003;54 Suppl 6:S32–45.PubMedCrossRefGoogle Scholar
  70. Singer HS, Mink JW, Gilbert DL, Jankovic J (eds). Tremor. In: Movement disorders in childhood. Philadelphia: Saunders Elsevier; 2010a. p. 129–138.Google Scholar
  71. Singer HS, Mink JW, Gilbert DL, Jankovic J (eds). Stereotypies. In: Movement disorders in childhood. Philadelphia: Saunders Elsevier; 2010b. p. 56–65.Google Scholar
  72. Snyderman SE, Sansaricq C, Pulomones MT. Successful long term therapy of biopterin deficiency. J Inherit Metab Dis. 1987;10:260–6.PubMedCrossRefGoogle Scholar
  73. Spiro AJ. Minipolymyoclonus: a neglected sign in childhood spinal muscular atrophy. Neurology. 1970;20:1124–6.CrossRefGoogle Scholar
  74. Tolosa E, Koller WC, Gerdhanik OS. Differential diagnosis and treatment of movement disorders. London: Butterworth-Heinemann; 1998. p. 68.Google Scholar
  75. Van Rootselaar A-F, van Schaik IN, van der Maagdenberg AM, et al. Familial cortical myoclonic tremor with epilepsy: a single syndromic classification for a group of pedigrees bearing common features. Mov Disord. 2005;20:665–73.PubMedCrossRefGoogle Scholar
  76. Vanasse M, Bedard P, Andermann F. Shuddering attacks in children: an early clinical manifestation of essential tremor. Neurology. 1976;26:1027–30.PubMedCrossRefGoogle Scholar
  77. Wilkins DE, Hallett M, Erba G. Primary generalised epileptic myoclonus: a frequent manifestation of minipolymyoclonus of central origin. J Neurol Neurosurg Psychiatry. 1985;48:506–16.PubMedCrossRefGoogle Scholar
  78. Willemsen MA, Verbeek MM, Kamsteeg EJ. Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis. Brain. 2010;133:1810–22.PubMedCrossRefGoogle Scholar
  79. Williamson S, Greene SE. Incidence of thyrotoxicosis in children: a national population based study in the UK and Ireland. Clin Endocrinol. 2010;72:358–63.CrossRefGoogle Scholar
  80. Yiu EM, Geevasinga N, Nicholson GA, et al. A retrospective review of X-linked Charcot-Marie-Tooth disease in childhood. Neurology. 2011;76:461–66.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Children’s Hospital WestmeadThe University of SydneySydneyAustralia

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