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A Passage Through the Ribosome by Cryo-EM

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Biophysical approaches to translational control of gene expression

Part of the book series: Biophysics for the Life Sciences ((BIOPHYS,volume 1))

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Abstract

Ribosome is a complex macromolecular machine responsible for the protein synthesis in all living organisms. During protein synthesis ribosome interacts with several translation factors and undergoes extensive conformational changes which are integral part of the translation process. Cryo-Electron Microscopy with powerful image-processing software has contributed immensely for elucidating those dynamic structural events; thereby our understanding on the intricate mechanisms of the translation process has advanced significantly. Understanding translation process and the mechanisms of the ribosomal functions are fundamental to our existence. In this chapter we briefly discussed the cryo-EM process and its application on the translation research and highlighted many of the exciting findings revealed through it.

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Authors and Affiliations

  1. Department of Biological Sciences, Indian Institute of Science Education and Research-Kolkata, P.O. BCKV campus main office, Mohanpur, 741252, Nadia, West Bengal, India

    Partha P. Datta & Ananya Chatterjee

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  1. Partha P. Datta
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  2. Ananya Chatterjee
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Correspondence to Partha P. Datta .

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  1. College Park, Cell Biology and Molecular Genetics, University of Maryland, Rm. 2135 Microbiology Building, College Park, 20742-4451, Maryland, USA

    Jonathan D. Dinman

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Datta, P.P., Chatterjee, A. (2012). A Passage Through the Ribosome by Cryo-EM. In: Dinman, J. (eds) Biophysical approaches to translational control of gene expression. Biophysics for the Life Sciences, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3991-2_2

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