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ECTO-NOX Proteins pp 1–18Cite as

The ENOX Protein Family

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Abstract

ECTO-NOX or ENOX (because of their cell surface location) proteins comprise a family of dicopper NAD(P)H oxidases of plants and animals that exhibit both oxidative and protein disulfide isomerase-like activities. The two biochemical activities, hydroquinone [NAD(P)H] oxidation and protein disulfide interchange, alternate to impart a time-keeping capability. Constitutive ENOX (CNOX or ENOX1) is ubiquitous and refractory to most drugs. A tumor-associated ENOX (tNOX or ENOX2) is cancer-specific and drug-inhibited. The physiological substrate for the oxidative activity appears to be hydroquinones of the plasma membrane such as reduced coenzyme Q10. ENOX1 and ENOX2 proteins are growth-related and drive cell enlargement. Also indicated are roles in aging of arNOX proteins potentially important, as well, to neurodegenerative diseases.

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    D. James Morré & Dorothy M. Morré

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Morré, D.J., Morré, D.M. (2012). The ENOX Protein Family. In: ECTO-NOX Proteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3958-5_1

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