Dual Functions of Nanoplasmonic Optical Antennas: Nanoplasmonic Gene Switches and Biosensors
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Within a living cell, the intracellular distribution is spatially nonuniform and dynamically changing over time in response to environmental cues. By focusing on electromagnetic fields down to dimensions smaller than the diffraction limit, nanoplasmonic optical antennas, functioning as nanoplasmonic gene switches, enable on- demand and spatially precise regulation of genetic activity to give rise to location-specific function. In addition to on-demand gene regulation, nanoplasmonic optical antennas also function as label-free biosensors that significantly enhance spectral information for plasmon resonance energy transfer, surface-enhanced Raman spectroscopy, and nanoplasmonic molecular rulers. “Spectral snapshots” (i.e., spectroscopic imaging) of the dynamically changing intracellular biochemical distribution can be obtained over time.
KeywordsPlasmon Resonance Local Field Enhancement Antenna Effect Polystyrene Nanospheres Plasmon Resonance Wavelength
The authors thank all current and previous BioPOETS for their invaluable scientific contribution to projects discussed in this book chapter. The authors acknowledge the National Institutes of Health (NIH) Nanomedicine Development Center for the Optical Control of Biological Function (PN2 EY018241) for financial support. The authors acknowledge the Siebel Foundation for graduate support S.E. Lee (Siebel Scholarship, Class of 2010). The authors acknowledge the Center for Nanostructured Materials and Technology (CNMT) of the Korea government for support of Y. Park.
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