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Dual Functions of Nanoplasmonic Optical Antennas: Nanoplasmonic Gene Switches and Biosensors

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Nanoplasmonic Sensors

Part of the book series: Integrated Analytical Systems ((ANASYS))

Abstract

Within a living cell, the intracellular distribution is spatially nonuniform and dynamically changing over time in response to environmental cues. By focusing on electromagnetic fields down to dimensions smaller than the diffraction limit, nanoplasmonic optical antennas, functioning as nanoplasmonic gene switches, enable on- demand and spatially precise regulation of genetic activity to give rise to location-specific function. In addition to on-demand gene regulation, nanoplasmonic optical antennas also function as label-free biosensors that significantly enhance spectral information for plasmon resonance energy transfer, surface-enhanced Raman spectroscopy, and nanoplasmonic molecular rulers. “Spectral snapshots” (i.e., spectroscopic imaging) of the dynamically changing intracellular biochemical distribution can be obtained over time.

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Acknowledgements

The authors thank all current and previous BioPOETS for their invaluable scientific contribution to projects discussed in this book chapter. The authors acknowledge the National Institutes of Health (NIH) Nanomedicine Development Center for the Optical Control of Biological Function (PN2 EY018241) for financial support. The authors acknowledge the Siebel Foundation for graduate support S.E. Lee (Siebel Scholarship, Class of 2010). The authors acknowledge the Center for Nanostructured Materials and Technology (CNMT) of the Korea government for support of Y. Park.

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Authors and Affiliations

  1. Department of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator Center, 408C Stanley Hall, Berkeley, CA, 94720-1762, USA

    Somin Eunice Lee, Younggeun Park & Luke P. Lee

  2. Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, South Korea

    Younggeun Park & Taewook Kang

Authors
  1. Somin Eunice Lee
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  2. Younggeun Park
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  3. Taewook Kang
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  4. Luke P. Lee
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Corresponding author

Correspondence to Luke P. Lee .

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Editors and Affiliations

  1. Dept. Applied Physics, Chalmers University of Technology, Fysikgränd 3, Göteborg, 412 96, Sweden

    Alexandre Dmitriev

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Lee, S.E., Park, Y., Kang, T., Lee, L.P. (2012). Dual Functions of Nanoplasmonic Optical Antennas: Nanoplasmonic Gene Switches and Biosensors. In: Dmitriev, A. (eds) Nanoplasmonic Sensors. Integrated Analytical Systems. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3933-2_4

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