Sensors pp 449-452 | Cite as

A Novel Optical Device for End Tidal Air Sampling in Breath Analysis

  • Claudio Loccioni
  • Lorenzo Scalise
  • Enrico Primo Tomasini
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 162)


The aim of this work is to present a novel breath sampling device, based on tuneable diode laser spectroscopy (TDLS). The proposed system is able to measure CO2 concentrations and flow on expired breath and to precisely separate different fractions from expired breath. The system integrates a flow meter and a CO2 measurement unit based on TDL spectroscopy, allowing the measurement of: either volume and CO2 concentrations, sampling of different breath fractions, breath-by-breath calculation of the volume of anatomical dead space (Fowler’s method) and end-tidal CO2 concentration values. The comparison of anatomical dead space estimations in data of single breaths obtained from 10 test subjects is reported in Table 80.1, deviations respect to Fowler’s method (calculation by four experts) are <3 %. The proposed system show good perspectives for the development of portable diagnostic instruments based on laser device (TDL spectroscopy) expanding the possibility of observing new species and decreasing costs and can contribute to the common effort to building of common sampling procedures for the analysis of volatile compounds.


Single Breath Breath Analysis Absorption Tube Wavelength Modulation Spectroscopy Anatomical Dead Space 
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  1. 1.
    Rahn H, Farhi LE (1964) Ventilation, perfusion and gas exchange – the VA/Q concept handbook of physiology. Section 3: respiration vol. 1. American Physiological Society, Washington, DC, pp 735–65Google Scholar
  2. 2.
    Paiva M (1973) Gas transport in the human lung. J Appl Physiol 35:401–410Google Scholar
  3. 3.
    Fowler WS (1948) Lung function studies: II. The respiratory dead space. Am J Physiol 154:405–16Google Scholar
  4. 4.
    Bartels J et al (1954) The respiratory dead space measured by single breath analysis of oxygen, carbon dioxide, nitrogen or helium. J Clin Invest 33:41CrossRefGoogle Scholar
  5. 5.
    Cumming G et al (1967) The influence of gaseous diffusion on the alveolar plateau at different lung volumes. Respir Physiol 2:386–398CrossRefGoogle Scholar
  6. 6.
    Miekisch W, Noeldge-Schomburg G (2004) Diagnostic potential of breath analysis – focus on volatile organic compounds. Clin Chim Acta 347:25–39CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Claudio Loccioni
    • 1
  • Lorenzo Scalise
    • 2
  • Enrico Primo Tomasini
    • 2
  1. 1.AEA srl, Loccioni GroupAngeli di Rosora (Ancona)Italy
  2. 2.Dipartimento di Ingegneria Industriale e Scienze MatematicheUniversità Politecnica delle MarcheAnconaItaly

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