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Optical Fiber Sensor for DNA Detection Based on Doubled-Tilted Bragg Grating

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Sensors

Abstract

The label-free detection of DNA strands based on Double Tilted Fiber Bragg Grating (DTFBG) has been demonstrated. The external fiber surface has been modified with peptide nucleic acid (PNA). The changes of the interference fringes visibility of the grating, due to the PNA-DNA binding, proved the occurred fiber hybridization. The re-use of the fiber for multiple measurements and the selectivity of the sensor have been also investigated

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References

  1. Fan X, White IM, Shopova SI, Zhu H, Suter JD, Sun Y (2008) Sensitive optical biosensors for unlabeled targets: a review. Anal Chim Acta 620:8–26

    Article  Google Scholar 

  2. Ruan Y, Schartner EP, Ebendorff-Heidepriem H, Hoffmann P, Monro TM (2007) Detection of quantum-dot labelled proteins using soft glass microstructured optical fibers. Opt Express 15:17819–17826

    Article  Google Scholar 

  3. Afshar VS, Ruan Y, Warren-Smith SC, Monro TM (2008) Enhanced fluorescence sensing using microstructured optical fibers: a comparison of forward and backward collection modes. Opt Lett 33:1473–1475

    Article  Google Scholar 

  4. Ryu G, Dagenais M, Hurley MT, DeShong P (2010) High specificity binding of lectins to carbohydrate-functionalized Fiber Bragg Gratings: a new model for biosensing applications. IEEE J Sel Top Quant 16:647–653

    Article  Google Scholar 

  5. Maguis S, Laffont G, Ferdinand P, Carbonnier B, Kham K, Mekhalif T, Millot M (2008) Biofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing. Opt Express 16:19049–19062

    Article  Google Scholar 

  6. Chen X, Zhang L, Zhou K, Davies E, Sugden K, Bennion I, Hughes M, Hine A (2007) Real-time detection of DNA interactions with long-period fiber-grating-based biosensor. Opt Lett 32:2541–2543

    Article  Google Scholar 

  7. DeLisa MP, Zhang Z, Shiloach M, Pilevar S, Davis CC, Sirkis JS, Bentley WE (2000) Evanescent wave long-period Fiber Bragg Grating as an immobilized antibody biosensor. Anal Chem 72: 2895–2900

    Article  Google Scholar 

  8. Sozzi M, Cucinotta A, Corradini R, Marchelli R, Konstantaki M, Pissadakis S, Selleri S (2011) Modification of a long period grating-based fiber optic for DNA biosensing. Proc SPIE 7894. Optical Fibers, Sensors, and Devices for Biomedical Diagnostics and Treatment XI, 78940J, 22–23 January 2011, San Francisco, USA.

    Google Scholar 

  9. Coscelli E, Sozzi M, Poli F, Passaro D, Cucinotta A, Selleri S, Corradini R, Marchelli R (2010) Toward a highly specific DNA biosensor: PNA-modified suspended-core photonic crystal fibers. IEEE J Sel Top Quant 16:967–972

    Article  Google Scholar 

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Correspondence to Stefano Selleri .

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Candiani, A. et al. (2014). Optical Fiber Sensor for DNA Detection Based on Doubled-Tilted Bragg Grating. In: Baldini, F., et al. Sensors. Lecture Notes in Electrical Engineering, vol 162. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3860-1_62

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  • DOI: https://doi.org/10.1007/978-1-4614-3860-1_62

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3859-5

  • Online ISBN: 978-1-4614-3860-1

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