The Proximal Tubule

  • Christopher J. Lote


The morphology of the proximal tubule cells was covered briefly in Chap. 2, but will be considered in more detail here. The proximal tubule is divisible into the convoluted portion, or pars convoluta, which begins immediately behind the glomerulus, and the straight portion, or pars recta, which passes into the medulla to become the loop of Henle. The cells of these two portions have somewhat different structures (Fig. 2.4) and there are cells of an intermediate type linking the two portions. The transport functions of the proximal tubule are primarily dependent on the pars convoluta cells.


Filtration Albumin Urea Histamine Bicarbonate 

Further Reading

  1. Aukland K, Bogusky RT, Renkin EM (1994) Renal cortical interstitium and fluid absorption by peritubular capillaries. Am J Physiol 266:F175–F184PubMedGoogle Scholar
  2. Berry CA, Verkman AS (1988) Osmotic gradient dependence of osmotic water permeability in rabbit proximal convoluted tubule. J Membr Biol 105:33–43PubMedCrossRefGoogle Scholar
  3. Dantzler WH, Wright SH, Lote CJ (1997) Organic solute transport. In: Jamison RL, Wilkinson R (eds) Nephrology. Chapman and Hall, London, pp 61–70Google Scholar
  4. Planelles G (2004) Chloride transport in the renal proximal tubule. Pflugers Arch 448:561–570PubMedCrossRefGoogle Scholar
  5. Van Itallie CM, Anderson JM (2004) The molecular physiology of tight junction pores. Physiology 19:331–338PubMedCrossRefGoogle Scholar
  6. Wright EM, Loo DDF, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91:733–794PubMedCrossRefGoogle Scholar
  7. Wakabayashi S, Shigekawa M, Pouyssegur J (1997) Moleccular physiology of vertebrate Na+/H+ exchangers. Physiol Rev 77:51–74PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Christopher J. Lote
    • 1
  1. 1.College of Medical and Dental SciencesUniversity of BirminghamBirminghamUK

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